Product Name

  • Name

    Butethamine

  • EINECS
  • CAS No. 553-68-4
  • Density 1.067g/cm3
  • Solubility
  • Melting Point 192-196°
  • Formula C13H20N2O2•ClH
  • Boiling Point 383.7°Cat760mmHg
  • Molecular Weight 272.775
  • Flash Point 185.9°C
  • Transport Information
  • Appearance
  • Safety A poison by intraperitoneal, intravenous, and subcutaneous routes. Used in veterinary medicine as local anesthetic. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 553-68-4 (Butethamine)
  • Hazard Symbols
  • Synonyms
  • PSA
  • LogP

Butethamine hydrochloride Chemical Properties

Product Name: Butethamine hydrochloride
CAS Registry Number: 553-68-4
IUPAC Name: 2-(2-methylpropylamino)ethyl 4-aminobenzoate hydrochloride
Molecular Weight: 272.77104 [g/mol]
Molecular Formula: C13H21ClN2O2
H-Bond Donor: 3
H-Bond Acceptor: 4
Surface Tension: 41.6 dyne/cm
Density: 1.067 g/cm3
Flash Point: 185.9 °C
Enthalpy of Vaporization: 63.23 kJ/mol
Boiling Point: 383.7 °C at 760 mmHg
Vapour Pressure: 4.3E-06 mmHg at 25°C 
Classification Code: Drug / Therapeutic Agent
Following is the molecular structure of Butethamine hydrochloride (CAS NO.553-68-4) is:

Butethamine hydrochloride Uses

 Butethamine hydrochloride (CAS NO.553-68-4) can be used in veterinary medicine as local anesthetic.

Butethamine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo subcutaneous 215mg/kg (215mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 62, Pg. 69, 1938.
mouse LD50 intraperitoneal 169mg/kg (169mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 483, 1958.
mouse LD50 intravenous 36mg/kg (36mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 483, 1958.
mouse LD50 subcutaneous 449mg/kg (449mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Anesthesiology. Vol. 3, Pg. 398, 1942.
rabbit LDLo intravenous 30mg/kg (30mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 62, Pg. 69, 1938.
rat LD50 intraperitoneal 182mg/kg (182mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Anesthesiology. Vol. 3, Pg. 398, 1942.
rat LD50 intravenous 28mg/kg (28mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Anesthesiology. Vol. 3, Pg. 398, 1942.

Butethamine hydrochloride Safety Profile

A poison by intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.

Butethamine hydrochloride Specification

 Butethamine hydrochloride , its cas register number is 553-68-4. It also can be called 2-(Isobutylamino)ethyl p-aminobenzoate hydrochloride ; 2-Isobutylaminoethanol hydrochloric acid salt, p-aminobenzoic acid ester ; Benzoic acid, p-amino-, 2-(isobutylamino)ethyl ester, hydrochloride ; Butethamine HCl  ; Ibylcaine hydrochloride ; Monocaine hydrochloride ; NSC 10821 ; UNII-0M63DKI91K ; p-Aminobenzoic acid 2-(isobutylamino)ethyl ester hydrochloride ; p-Aminobenzoic acid ester of 2-isobutylaminoethanol ; hydrochloric acid salt ; Ethanol, 2-((2-methylpropyl)amino)-, 4-aminobenzoate
(ester), monohydrochloride (9CI) ; Ethanol, 2-(isobutylamino)-, p-aminobenzoate (ester), monohydrochloride .

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