-
Name
HYDRAZINECARBOXYLIC ACID, 2-[6-[ETHYL(2-HYDROXYPROPYL)AMINO]-3-PYRIDAZINYL]-, ETHYL ESTER
- EINECS
- CAS No. 64241-34-5
- Article Data4
- CAS DataBase
- Density 1.253 g/cm3
- Solubility
- Melting Point 160-162°
- Formula C12H21 N5 O3
- Boiling Point 425.88°C (rough estimate)
- Molecular Weight 283.33
- Flash Point
- Transport Information
- Appearance
- Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
- Risk Codes
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Molecular Structure
- Hazard Symbols
- Synonyms CGP 18684E;Cadral; Cadralazine; Cadraten; Cadrilan; DC 826; ISF 2469; Presmode
- PSA 99.61000
- LogP 1.22060
Cadralazine Chemical Properties
Chemistry informtion about Cadralazine (CAS NO.64241-34-5) is:
IUPAC Name: Ethyl N-[[6-[Ethyl(2-Hydroxypropyl)Amino]Pyridazin-3-Yl]Amino]Carbamate
Synonyms: Hydrazinecarboxylic Acid, 2-[6-[Ethyl(2-Hydroxypropyl)Amino]-3-Pyridazinyl]-, Ethyl Ester ; Cadralazine ; Cadral ; Cadraten ; Cadrilan ; Cgp 18684e ; Dc 826 ; Isf 2469
MF: C12H21N5O3
MW: 283.33
Density: 1.253 g/cm3
Following is the molecular structure of Cadralazine (CAS NO.64241-34-5) is:
Cadralazine Production
Raw materials are Ethyl carbazate-->Amino-2-propanol-->Phthalazine .
Cadralazine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 400mg/kg (400mg/kg) | cardiac: change in rate vascular: bp lowering not characterized in autonomic section kidney, ureter, and bladder: changes in blood vessels or in circulation of kidney | Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981. |
| dog | LD50 | oral | > 2gm/kg (2000mg/kg) | Drugs of the Future. Vol. 7, Pg. 382, 1982. | |
| mouse | LD50 | intraperitoneal | 362mg/kg (362mg/kg) | Drugs of the Future. Vol. 7, Pg. 382, 1982. | |
| mouse | LD50 | intravenous | 162mg/kg (162mg/kg) | Drugs of the Future. Vol. 7, Pg. 382, 1982. | |
| mouse | LD50 | oral | 825mg/kg (825mg/kg) | Drugs of the Future. Vol. 7, Pg. 382, 1982. | |
| mouse | LD50 | subcutaneous | 1420mg/kg (1420mg/kg) | sense organs and special senses: ptosis: eye behavioral: altered sleep time (including change in righting reflex) lungs, thorax, or respiration: dyspnea | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3839, 1987. |
| rat | LD50 | intraperitoneal | 440mg/kg (440mg/kg) | Drugs of the Future. Vol. 7, Pg. 382, 1982. | |
| rat | LD50 | intravenous | 269mg/kg (269mg/kg) | cardiac: change in rate vascular: bp lowering not characterized in autonomic section | Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981. |
| rat | LD50 | oral | 2060mg/kg (2060mg/kg) | cardiac: change in rate vascular: bp lowering not characterized in autonomic section | Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981. |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | sense organs and special senses: ptosis: eye behavioral: altered sleep time (including change in righting reflex) liver: other changes | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3839, 1987 |
Cadralazine Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Cadralazine Specification
Cadralazine (CAS NO.64241-34-5) is an antihypertensive of the hydrazine chemical class.
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