Product Name

  • Name

    SODIUM CAMPTOTHECIN

  • EINECS
  • CAS No. 25387-67-1
  • Article Data2
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point
  • Formula C20H18 N2 O5 . Na
  • Boiling Point 777.3°C at 760 mmHg
  • Molecular Weight 370.36
  • Flash Point 423.9°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion and intravenous routes. Human systemic effects by intravenous route: reduction in the number of white blood cells (leukopenia), reduction in the number of blood platelets (thrombocytopenia), and changes in blood cell count. When heated to decomposition it emits toxic fumes of NOx and Na2O.
  • Risk Codes
  • Molecular Structure Molecular Structure of 25387-67-1 (SODIUM CAMPTOTHECIN)
  • Hazard Symbols
  • Synonyms 21,22-Secocamptothecin-21-oicacid, monosodium salt (8CI); Indolizino[1,2-b]quinoline-7-acetic acid, a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-,monosodium salt, (S)-; Indolizino[1,2-b]quinoline-7-acetic acid, a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-,monosodium salt, (aS)- (9CI); 20(S)-Camptothecin sodium salt; Camptothecin sodium;Camptothecine sodium; NSC 100880; Sodium camptothecin
  • PSA 115.48000
  • LogP 0.26500

Camptothecin, sodium salt Chemical Properties

IUPAC Name: (2R)-2-Hydroxy-2-[8-(hydroxymethyl)-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]butanoic acid ; Sodium
Following is the structure of Camptothecin, sodium salt (CAS NO.25387-67-1):
                 
Empirical Formula: C20H18N2NaO5
Molecular Weight: 389.3571 g/mol
Flash Point: 423.9 °C
Enthalpy of Vaporization: 118.67 kJ/mol
Boiling Point: 777.3 °C at 760 mmHg
Vapour Pressure of Camptothecin, sodium salt (CAS NO.25387-67-1): 1.96E-25 mmHg at 25 °C
Canonical SMILES: CCC(C1=C(C(=O)N2CC3=CC4=CC=CC=C4N=C3C2=C1)CO)(C(=O)O)O.[Na]
Isomeric SMILES: CC[C@@](C1=C(C(=O)N2CC3=CC4=CC=CC=C4N=C3C2=C1)CO)(C(=O)O)O.[Na]
InChI: InChI=1S/C20H18N2O5.Na/c1-2-20(27,19(25)26)14-8-16-17-12(9-22(16)18(24)13(14)10-23)7-11-5-3-4-6-15(11)21-17;/h3-8,23,27H,2,9-10H2,1H3,(H,25,26);/t20-;/m1./s1
InChIKey: PBJLMBQVBUDNJL-VEIFNGETSA-N

Camptothecin, sodium salt Toxicity Data With Reference

1.    

ivn-hmn TDLo:2500 µg/kg/7D-I:BLD

     CCROBU    Cancer Chemotherapy Reports, Part 1. 56 (1972),515.
2.    

orl-mus LD50:27 mg/kg

     PMDCAY    Progress in Medical Chemistry. 9 (1973),1.
3.    

ivn-mus LD50:57 mg/kg

     PMDCAY    Progress in Medical Chemistry. 9 (1973),1.

Camptothecin, sodium salt Safety Profile

Poison by ingestion and intravenous routes. Human systemic effects by intravenous route: reduction in the number of white blood cells (leukopenia), reduction in the number of blood platelets (thrombocytopenia), and changes in blood cell count. When heated to decomposition, Camptothecin, sodium salt (CAS NO.25387-67-1) emits toxic fumes of NOx and Na2O.

Camptothecin, sodium salt Specification

 Camptothecin, sodium salt , its cas register number is 25387-67-1. It also can be called 20(S)-Camptothecin sodium salt ;
21,22-Secocamptothecin-21-oic acid, monosodium salt ; Camptothecin sodium ; Camptothecine sodium ; and Sodium camptothecin . Its classification code are Drug / Therapeutic Agent; Human Data and Natural Product.

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