Carbendazim (Albendazole EP Impurity E) is a fungicide and an impurity of Albendazole.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LD50 | oral | 1800mg/kg (1800mg/kg) | Indian Journal of Pharmacology. Vol. 18, Pg. 102, 1986. | |
dog | LD50 | oral | > 2500mg/kg (2500mg/kg) | Pesticide Manual. Vol. 9, Pg. 123, 1991. | |
guinea pig | LD50 | oral | 4150mg/kg (4150mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 58, 1987. |
mouse | LD50 | intraperitoneal | 1225mg/kg (1225mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 58, 1987. |
mouse | LD50 | oral | 7700mg/kg (7700mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(5), Pg. 49, 1981. |
quail | LD50 | oral | > 10gm/kg (10000mg/kg) | Pesticide Manual. Vol. 9, Pg. 123, 1991. | |
rabbit | LD50 | oral | 8160mg/kg (8160mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 58, 1987. |
rabbit | LD50 | skin | 8500mg/kg (8500mg/kg) | Indian Journal of Pharmacology. Vol. 18, Pg. 102, 1986. | |
rat | LD50 | intraperitoneal | 1720mg/kg (1720mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 58, 1987. |
rat | LD50 | oral | 6400mg/kg (6400mg/kg) | "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revisionVol. 4, Pg. 131, 1976/1977. | |
rat | LD50 | skin | 2gm/kg (2000mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. |
Safety Info | |
Symbol: | GHS08 GHS09 |
---|---|
Sign: | Danger |
hazard declaration: | H340; H360FD; H410 |
hazard declaration add: | |
waring notice: | P201; P273; P308 + P313; P501 |
RTECS: | DD6500000 |
Safety Statements: | S53-S45-S60-S61 |
HS Code: | 2933990013 |
WGK Germany: | 3 |
RIDADR: | UN 3077 |
Risk Statements: | R46; R60; R61; R50/53 |
Hazard Codes: | T |
The CAS registry number of Carbendazim is 10605-21-7. The IUPAC name is methyl N-(1H-benzimidazol-2-yl)carbamate. In addition, the molecular formula is C9H9N3O2. What's more, it is a widely used broad-spectrum benzimidazole fungicide. It can be used as microbicides for barley, fruits and vegetables.
Physical properties about this chemical are: (1)ACD/LogP: 1.52; (2)ACD/LogD (pH 5.5): 0.76; (3)ACD/LogD (pH 7.4): 1.49; (4)ACD/BCF (pH 5.5): 1.46; (5)ACD/BCF (pH 7.4): 7.93; (6)ACD/KOC (pH 5.5): 27.74; (7)ACD/KOC (pH 7.4): 150.69; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 47.36 Å2; (12)Index of Refraction: 1.711; (13)Molar Refractivity: 52.63 cm3; (14)Molar Volume: 134.5 cm3; (15)Polarizability: 20.86 ×10-24cm3; (16)Surface Tension: 69.3 dyne/cm; (17)Density: 1.421 g/cm3.
Preparation of Carbendazim: it can be prepared by o-benzenediamine and cyanogen methyl carbamate. The cyanogen methyl carbamate can be obtained by methyl chloroformate and cyanamide.
When you are using this chemical, please be cautious about it as the following:
This chemical is highly flammable. It is very toxic to aquatic organisms, which may cause long-term adverse effects in the aquatic environment and may cause heritable genetic damage. And it is toxic by inhalation, in contact with skin and if swallowed. Moreover, it may impair fertility and may cause harm to the unborn child. You should avoid exposure - obtain special instruction before use. During using it, wear suitable protective clothing and gloves. And in case of accident or if you feel unwell, seek medical advice immediately (show label where possible). What's more, this material and/or its container must be disposed of as hazardous waste. You avoid release to the environment and you can refer to special instructions safety data sheet.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OC)Nc2nc1ccccc1n2
(2)InChI: InChI=1/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13)
(3)InChIKey: TWFZGCMQGLPBSX-UHFFFAOYAS
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LD50 | oral | 1800mg/kg (1800mg/kg) | Indian Journal of Pharmacology. Vol. 18, Pg. 102, 1986. | |
dog | LD50 | oral | > 2500mg/kg (2500mg/kg) | Pesticide Manual. Vol. 9, Pg. 123, 1991. | |
guinea pig | LD50 | oral | 4150mg/kg (4150mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 58, 1987. |
mouse | LD50 | intraperitoneal | 1225mg/kg (1225mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 58, 1987. |
mouse | LD50 | oral | 7700mg/kg (7700mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(5), Pg. 49, 1981. |
quail | LD50 | oral | > 10gm/kg (10000mg/kg) | Pesticide Manual. Vol. 9, Pg. 123, 1991. | |
rabbit | LD50 | oral | 8160mg/kg (8160mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 58, 1987. |
rabbit | LD50 | skin | 8500mg/kg (8500mg/kg) | Indian Journal of Pharmacology. Vol. 18, Pg. 102, 1986. | |
rat | LD50 | intraperitoneal | 1720mg/kg (1720mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 58, 1987. |
rat | LD50 | oral | 6400mg/kg (6400mg/kg) | "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revisionVol. 4, Pg. 131, 1976/1977. | |
rat | LD50 | skin | 2gm/kg (2000mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. |
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