Cefcapene pivoxil hydrochloride

Molecular Structure of Cefcapene pivoxil hydrochloride (CAS NO.147816-24-8):

IUPAC Name: 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(E)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-(carbamoyloxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrate hydrochloride 
Molecular Formula:C₂₃H₂₉N₅O₈S₂.HCl.H₂O
Molecular Weight:622.11
ACD/LogP: 1.10
of Rule of 5 Violations: 3
ACD/LogD (pH 5.5): 1.02
ACD/LogD (pH 7.4): 1.1
ACD/BCF (pH 5.5): 3.39
ACD/BCF (pH 7.4): 4.02
ACD/KOC (pH 5.5): 79.41
ACD/KOC (pH 7.4): 94.22
H bond acceptors: 13
H bond donors: 5
Freely Rotating Bonds: 13
Polar Surface Area: 192.43Ų
Flash Point: 491.1 °C
Enthalpy of Vaporization: 129.15 kJ/mol
Boiling Point: 888.4 °C at 760 mmHg
Vapour Pressure: 3.51E-32 mmHg at 25°C
Appearance: Off-White Solid
Product Categories: Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds
Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, monohydrate,(6R,7R)- (9CI) ; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[[(aminocarbonyl)oxy]methyl]-7-[[2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino]-8-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, monohydrate, [6R-[6a,7b(Z)]]- ; Cefcapene pivoxil hydrochloride hydrate
Smiles
N12C([C@H]([C@H]1SCC(COC(=O)N)=C2C(=O)OCOC(C(C)(C)C)=O)NC(\C(=C\CC)c1nc(sc1)N)=O)=O.ClO

 Cefcapene pivoxil hydrochloride (CAS NO.147816-24-8) is used as antibacterial.It is orally absorbed cephalosporin.

 Cefcapene pivoxil hydrochloride (CAS NO.147816-24-8) is an oral 3rd-generation cephalosporin with a wide spectrum of activity. It has been in use since 1997 only in Japan. As well as gastrointestinal symptoms, it has been reported to the manufacturer as causing rashes. There are 5 b-lactams  that have a pivaloyloxymethyl base as a side chain, e.g., pivmecillinam, cefteram pivoxil, cefetamet pivoxil, cefditoren pivoxil and cefcapene pivoxil hydrochloride .