The Cefteram pivoxil, with the CAS registry number 82547-81-7, is also known as Pivaloyloxymethyl (Z)-7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(5-methyl-2H-tetrazol-2-ylmethyl)-3-cephem-4-carboxylate. It belongs to the product categories of Amines; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds. This chemical's molecular formula is C22H27N9O7S2 and molecular weight is 593.64. What's more, its systematic name is [(2,2-Dimethylpropanoyl)oxy]methyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxy late. Its classification codes are: (1)Anti-Bacterial Agents; (2)Anti-Infective Agents; (3)Drug / Therapeutic Agent; (4)Reproductive Effect.
Physical properties of Cefteram pivoxil are: (1)ACD/LogP: 2.01; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 2.01; (4)ACD/LogD (pH 7.4): 1.93; (5)ACD/BCF (pH 5.5): 19.77; (6)ACD/BCF (pH 7.4): 16.46; (7)ACD/KOC (pH 5.5): 294.16; (8)ACD/KOC (pH 7.4): 245.03; (9)#H bond acceptors: 16; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 12; (12)Polar Surface Area: 259.65 Å2; (13)Index of Refraction: 1.744; (14)Molar Refractivity: 144.698 cm3; (15)Molar Volume: 357.226 cm3; (16)Polarizability: 57.363×10-24cm3; (17)Surface Tension: 70.5 dyne/cm; (18)Density: 1.662 g/cm3.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)Cn4nc(nn4)C)C(=O)OCOC(=O)C(C)(C)C
(2)Std. InChI: InChI=1S/C22H27N9O7S2/c1-10-26-29-30(27-10)6-11-7-39-18-14(25-16(32)13(28-36-5)12-8-40-21(23)24-12)17(33)31(18)15(11)19(34)37-9-38-20(35)22(2,3)4/h8,14,18H,6-7,9H2,1-5H3,(H2,23,24)(H,25,32)/b28-13-/t14-,18-/m1/s1
(3)Std. InChIKey: UIYAXIPXULMHAI-JLGRZTKVSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | > 2gm/kg (2000mg/kg) | Chemotherapy Vol. 34 | |
mouse | LD50 | intraperitoneal | 5860mg/kg (5860mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 34 |
mouse | LD50 | oral | > 6gm/kg (6000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 34 |
mouse | LD50 | subcutaneous | > 6gm/kg (6000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 34 |
rat | LD50 | intraperitoneal | 5090mg/kg (5090mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 34 |
rat | LD50 | oral | > 6gm/kg (6000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Chemotherapy Vol. 34 |
rat | LD50 | subcutaneous | > 6gm/kg (6000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Chemotherapy Vol. 34 |
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