Product Name

  • Name

    Chlorozotocin

  • EINECS
  • CAS No. 54749-90-5
  • Density 1.858g/cm3
  • Solubility
  • Melting Point 147-148° (dec with the evolution of gas); mp 140-141° (dec)
  • Formula C9H16 Cl N3 O7
  • Boiling Point 119.3°C (rough estimate)
  • Molecular Weight 313.73
  • Flash Point
  • Transport Information
  • Appearance
  • Safety Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also NITROSAMINES.
  • Risk Codes
  • Molecular Structure Molecular Structure of 54749-90-5 (Chlorozotocin)
  • Hazard Symbols
  • Synonyms CHLZ;Chlorozotocin; Chlorozotocine; DCNU; NCI 178248; NSC 178248
  • PSA
  • LogP

Chlorozotocin Chemical Properties

IUPAC Name: 1-(2-Chloroethyl)-1-nitroso-3-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]urea
Synonyms of Chlorozotocin (CAS NO.54749-90-5) : 1-(2-Chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea ; 2-({[(2-Chloroethyl)(nitroso)amino]carbonyl}amino)-2-deoxy-alpha-D-glucopyranose ; DCNU
CAS NO: 54749-90-5
Molecular Formula:C9H16ClN3O7
Molecular Weight :313.6922
Molecular Structure :
Index of Refraction: 1.664
Surface Tension: 78.6 dyne/cm
Density: 1.85 g/cm3

Chlorozotocin Uses

 Chlorozotocin (CAS NO.54749-90-5) is a nitrosourea used for cancer therapy.

Chlorozotocin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 3mg/kg (3mg/kg) GASTROINTESTINAL: CHANGE IN STRUCTURE OR FUNCTION OF ESOPHAGUS
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"		 Toxicology. Vol. 12, Pg. 31, 1979.
human TDLo intravenous 2027ug/kg/5D (2.027mg/kg) BLOOD: LEUKOPENIA
BLOOD: THROMBOCYTOPENIA
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE		 Cancer Treatment Reports. Vol. 63, Pg. 17, 1979.
man TDLo intravenous 500mg/kg (500mg/kg) BEHAVIORAL: ANOREXIA (HUMAN
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: THROMBOCYTOPENIA		 Cancer Vol. 46, Pg. 2365, 1980.
monkey LDLo oral 400mg/kg (400mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)
GASTROINTESTINAL: NAUSEA OR VOMITING		 Toxicology. Vol. 12, Pg. 31, 1979.
mouse LD50 intraperitoneal 35mg/kg (35mg/kg)   INSERM Symposium. Vol. 19, Pg. 123, 1981.
mouse LD50 intravenous 24900ug/kg (24.9mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
BLOOD: CHANGES IN SPLEEN		 Toxicology. Vol. 12, Pg. 31, 1979.
mouse LD50 subcutaneous 66230ug/kg (66.23mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat LD50 intraperitoneal 28mg/kg (28mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
GASTROINTESTINAL: OTHER CHANGES		 Cancer Letters Vol. 8, Pg. 133, 1979.
rat LD50 intravenous 22500ug/kg (22.5mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH		 Oncology. Vol. 37, Pg. 177, 1980.
rat LDLo subcutaneous 40mg/kg (40mg/kg)   Toxicology and Applied Pharmacology. Vol. 82, Pg. 540, 1986.

Chlorozotocin Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 50 , 1990,p. 65.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 50 , 1990,p. 65.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 50 , 1990,p. 65.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Chlorozotocin Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When Chlorozotocin (CAS NO.54749-90-5) is heated to decomposition, it emits very toxic fumes of Cl− and NOx. See also NITROSAMINES.

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