Product Name

  • Name

    CHLORTHION

  • EINECS
  • CAS No. 500-28-7
  • Article Data5
  • CAS DataBase
  • Density 1.499g/cm3
  • Solubility 40mg/L(20 oC)
  • Melting Point 21°
  • Formula C8H9 Cl N O5 P S
  • Boiling Point 366.6°Cat760mmHg
  • Molecular Weight 297.656
  • Flash Point 175.5°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by ingestion, skin contact, and intraperitoneal routes. An insecticide. Decomposes and then ignites when heated above 270°C. When heated to decomposition it emits very toxic fumes of Cl−, SOx, POx, and NOx.
  • Risk Codes R20/21/22; R50/53
  • Molecular Structure Molecular Structure of 500-28-7 (CHLORTHION)
  • Hazard Symbols Xn,N
  • Synonyms Phosphorothioicacid, O-(3-chloro-4-nitrophenyl) O,O-di-Me ester (6CI); BAY 22190; Chlorothion;Chlorthion; Chlorthion methyl; Compound 22/190; Methylchlorothion; NSC 8927;O,O-Dimethyl O-(3-chloro-4-nitrophenyl) thiophosphate; O,O-DimethylO-(3-chloro-4-nitrophenyl)thionophosphate; O,O-DimethylO-3-chloro-4-nitrophenyl phosphorothioate; O-(3-Chloro-4-nitrophenyl)O,O-dimethyl phosphorothioate; OMS 217
  • PSA 115.41000
  • LogP 4.31810

Chlorthion Chemical Properties

The IUPAC name of Chlorthion (CAS NO.500-28-7):
(3-Chloro-4-nitrophenoxy)-dimethoxy-sulfanylidene-{5}-phosphane
Synonyms: 3-Chloro-4-nitrophenyldimethylphosphorothioate ; Bay 22190 ; Bay22190 ; Bay22190[qr] ; Bayer 22/190 ; Chloorthion ; Chloorthion[dutch] ; Chlorothion
CAS: 500-28-7 
EINECS: 207-902-5
Molecular Formula: C8H9ClNO5PS 
Molecular Structure:

Formula Weight: 297.65 g/mol
Index of Refraction: 1.586 
Density: 1.499 g/cm3 
Flash Point: 175.5 °C 
Boiling Point: 366.6 °C at 760 mmHg 

Chlorthion Toxicity Data With Reference

The toxicity of Chlorthion (CAS NO.500-28-7):

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 20mg/kg (20mg/kg)   Journal de Toxicologie Clinique et Experimentale. Vol. 6(3), Pg. 175, 1986.
guinea pig LD50 intraperitoneal 525mg/kg (525mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 626, 1955.
guinea pig LD50 subcutaneous 25mg/kg (25mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
mouse LD50 oral 794mg/kg (794mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Archives of Toxicology. Vol. 41, Pg. 111, 1978.
rabbit LD50 subcutaneous 25mg/kg (25mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
rabbit LDLo oral 1gm/kg (1000mg/kg)   Journal of Economic Entomology. Vol. 48, Pg. 139, 1955.
rat LD50 intraperitoneal 750mg/kg (750mg/kg)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 350, 1953.
rat LD50 intraperitoneal 750mg/kg (750mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 350, 1953.
rat LD50 oral 285mg/kg (285mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
rat LD50 skin 1500mg/kg (1500mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat LD50 subcutaneous 47mg/kg (47mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
rat LD50 unreported 880mg/kg (880mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 331, 1971.

Chlorthion Safety Profile

The Hazard Codes of Chlorthion (CAS NO.500-28-7): HarmfulXnDangerousN
Risk Statements:R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:S13:Keep away from food, drink and animal foodstuffs. S60:This material and its container must be disposed of as hazardous waste. S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
Moderately toxic by ingestion, skin contact, and intraperitoneal routes. An insecticide. Decomposes and then ignites when heated above 270°C. When heated to decomposition it emits very toxic fumes of Cl−, SOx, POx, and NOx.

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