Choline chloride supplier

Name
Choline chloride
EINECS 200-655-4
CAS No. 67-48-1
Article Data39
CAS DataBase
Density 1.205 g/cm3
Solubility soluble in water
Melting Point 302-305 °C (dec.)(lit.)
Formula C₅H₁₄ClNO
Boiling Point
Molecular Weight 139.625
Flash Point
Transport Information
Appearance White crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Choline hydrochloride;Choline chloride solutions;(2-Hydroxyethyl)trimethylammonium chloride;Cholinum;Ethanaminium, 2-hydroxy-N,N, N-trimethyl-, chloride;Hormocline;Colina cloruro [DCIT];2-Hydroxy-N,N,N-trimethylethanaminium chloride;Ammonium, (2-hydroxyethyl)trimethyl-, chloride;2-Hydroxy-N,N,N-trimethylethanaminium;Cholinium chloride;sell choline chloride;Bilineurin chloride;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-;Paresan;2-hydroxyethyl-trimethyl-azanium;Neocolina;Choline chlorhydrate;Lipotril;2-Hydroxy-N,N,N-trimethylammonium chloride;Choline, chloride;Chloride de choline [French];Chlorure de choline [INN-French];Biocolina;Cholini chloridum [INN-Latin];2-hydroxyethyl-trimethyl-azanium chloride;
PSA 20.23000
LogP -3.31110

Synthetic route

: 75-21-8
oxirane

: 593-81-7
trimethylamine hydrochloride

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With sodium hydroxide at 24.9℃; Thermodynamic data; ΔrH1;	100%
With sodium hydroxide at 24.9℃;	100%

: 107-07-3
2-chloro-ethanol

: 75-50-3
trimethylamine

: 67-48-1
choline chloride

Conditions

Conditions	Yield
In methanol; acetonitrile at 70℃; for 14h; Inert atmosphere;	98%
at 80℃;
With water

: 64-17-5
ethanol

: C25H25Cl2N2O3(1+)*Cl(1-)

A: ethyl 3-amino-1-(2,4-dichlorophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 9h;	A 88% B n/a

...Expand

: 64-17-5
ethanol

: C25H26BrN2O3(1+)*Cl(1-)

A: 330957-88-5
ethyl 3-amino-1-(4-bromo phenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 9h;	A 84% B n/a

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 299937-04-5
ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 83% B n/a

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 330957-87-4
ethyl 3-amino-1-(4-nitro phenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 74% B n/a

...Expand

: 64-17-5
ethanol

: C26H29N2O4(1+)*Cl(1-)

A: 67-48-1
choline chloride

B: 119825-14-8
ethyl 3-amino-1-(4-methoxyphenyl)-1H-benzo[f]chromene-2-carboxylate

Conditions

Conditions	Yield
With diethylamine at 40℃; for 11h;	A n/a B 73%

...Expand

: 64-17-5
ethanol

: C25H26ClN2O3(1+)*Cl(1-)

A: 67-48-1
choline chloride

B: 130944-14-8
ethyl 3-amino-1-(4-chlorophenyl)-1H-benzo[f]chromene-2-carboxylate

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A n/a B 70%

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 405109-32-2
ethyl 3-amino-1-(2-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 70% B n/a

...Expand

: 64-17-5
ethanol

: C26H26N3O3(1+)*Cl(1-)

A: 405109-16-2
C23H18N2O3

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 11h;	A 68% B n/a

...Expand

: 64-17-5
ethanol

: 1277100-30-7
C25H27N2O3(1+)*Cl(1-)

A: 67-48-1
choline chloride

B: 84186-26-5
2-amino-3-ethoxycarbonyl-4-phenyl-4H-naphtho<2,1-b>pyran

Conditions

Conditions	Yield
With diethylamine at 40℃; for 8h;	A n/a B 67%

...Expand

: 64-17-5
ethanol

: C27H31N2O5(1+)*Cl(1-)

A: 1277100-29-4
C24H23NO5

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 12h;	A 66% B n/a

...Expand

: 64-17-5
ethanol

: C25H27N2O4(1+)*Cl(1-)

A: 67-48-1
choline chloride

B: 130944-15-9
ethyl 3-amino-1-(4-hydroxy phenyl)-1H-benzo[f]chromene-2-carboxylate

Conditions

Conditions	Yield
With diethylamine at 40℃; for 12h;	A n/a B 60%

...Expand

: 74-83-9
methyl bromide

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With boron fluoride ether; acetone

: 64-17-5
ethanol

: 60-31-1
acetylcholine chloride

: 67-48-1
choline chloride

Conditions

Conditions	Yield
beim Umkrystallisieren;

: 2758-06-7
(2-bromoethyl)trimethylammonium bromide

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With silver nitrate

: 141-43-5
ethanolamine

: 74-88-4
methyl iodide

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With potassium hydroxide
Stage #1: ethanolamine; methyl iodide With potassium carbonate for 12h; Stage #2: With silver(l) oxide In methanol for 0.25h;

: 593-81-7
trimethylamine hydrochloride

: 107-07-3
2-chloro-ethanol

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With sodium hydroxide; trimethylamine at -12 - -10℃; Erhitzen auf 80-90grad;

: 60-31-1
acetylcholine chloride

A: 67-48-1
choline chloride

B: 64-19-7
acetic acid

Conditions

Conditions	Yield
With macrocyclic polyphenolate; water at 60℃; Rate constant; Equilibrium constant; Mechanism; pH 10.0; ionic strength 0.10 M; var. pH;

: 107-73-3
phosphorylcholine chloride

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With water at 30℃; for 0.166667h; Rate constant; relative rate, different alkaline phosphotases;

: 2964-09-2
benzoylcholine chloride

A: 67-48-1
choline chloride

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With sodium phosphate buffer at 25.2℃; Rate constant; Mechanism; Electrophorus electricus acetylcholinesterase (EC 3.1.1.7), pH 7.26, μ=0.3 (0.06 N NaCl), also Torpedo californica acetylcholinesterase; other choline and thiocholine esters;

: 81372-19-2
<2-(n-dodecylmethyl-tert-butylsiloxy)ethyl>trimethylammonium nitrate

A: 67-48-1
choline chloride

B: 81372-22-7
n-dodecylmethyl-tert-butylsilanol

Conditions

Conditions	Yield
With potassium fluoride In water-d2 at 25℃; for 24h; stability/lability; var. solvents, reagents and reaction times;

: 7647-01-0
hydrogenchloride

: 816-94-4, 4539-70-2, 66701-63-1, 816-93-3
{2-[(2,3-bis-stearoyloxy-propoxy)-hydroxy-phosphoryloxy]-ethyl}-trimethyl-ammonium betaine

A: 67-48-1
choline chloride

B α,β-distearoyl-glycerol-α'-phosphoric acid: α,β-distearoyl-glycerol-α'-phosphoric acid

...Expand

calve's brain: calve's brain

: 67-48-1
choline chloride

Conditions

Conditions	Yield
bei der Autolyse;

egg yolk: egg yolk

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With ethanol; barytes Isolieren mit konz.Ueberchlorsaeure;

lecithins: lecithins

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With acid Hydrolysis.Lecithine aus Maiskeimen;
With alkali Hydrolysis.Lecithine aus Maiskeimen;
With acid Hydrolysis.Lecithine aus den Samen von Avena sativa;

lupinus albus L.: lupinus albus L.

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With alkali Hydrolysis.Lecithine den Samen von Lupinus albus L.;

phosphorus containing substance from bovine kidneys: phosphorus containing substance from bovine kidneys

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With barium dihydroxide; ethanol

rohoryzanin I: rohoryzanin I

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With hydrogenchloride Hydrolysis;
With sulfuric acid Hydrolysis;

: 67-48-1
choline chloride

: 57-13-6
urea

: urea/choline chloride eutectic salt

Conditions

Conditions	Yield
at 70 - 80℃; for 0.333333h;	100%
at 120℃; for 0.333333h; Neat (no solvent);
at 74℃;

: 67-48-1
choline chloride

: 57-13-6
urea

: (2-hydroxyethyl)trimethylazanium urea chloride

Conditions

Conditions	Yield
at 70 - 80℃;	100%
at 80℃; for 0.5h;
at 50℃; Inert atmosphere;

: 67-48-1
choline chloride

: 577-11-7
sodium docusate

: 1214261-62-7
choline dioctylsulfosuccinate

Conditions

Conditions	Yield
In water; acetone at 20℃;	100%

: 141-82-2
malonic acid

: 67-48-1
choline chloride

: choline malonate

Conditions

Conditions	Yield
at 100℃;	100%
at 20℃; for 24h;
at 50 - 120℃;
at 80℃;

: 67-48-1
choline chloride

: 54-21-7
sodium salicylate

: 2016-36-6
choline salicylate

Conditions

Conditions	Yield
In acetone for 72h;	100%
In ethanol at 20℃; for 1h;

: 67-48-1
choline chloride

: 144-62-7
oxalic acid

: oxaline

Conditions

Conditions	Yield
at 100℃;	100%
at 50 - 120℃;
at 80 - 100℃;
at 90℃; for 1h;

: 4202-38-4
dodecyl isocyanate

: 67-48-1
choline chloride

: N-dodecylcarbamylcholine chloride

Conditions

Conditions	Yield
In acetonitrile at 85℃; for 24h;	100%

: 67-48-1
choline chloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: 2-hydroxy-N,N,N-trimethylethan-1-aminium hydrogen (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate

Conditions

Conditions	Yield
Stage #1: choline chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 67-48-1
choline chloride

: 118072-93-8
1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

: bis(2-hydroxy-N,N,N-trimethylethan-1-aminium) (1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)bis(hydrogen phosphonate)

Conditions

Conditions	Yield
Stage #1: choline chloride With anion-exchange column A-26 (OH) In methanol Stage #2: 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid In methanol; water for 1h;	100%

: 67-48-1
choline chloride

: 108-29-2
5-methyl-dihydro-furan-2-one

: 1211890-41-3
cholinium 4-hydroxyvalerate

Conditions

Conditions	Yield
In water at 25℃; for 1h;	99.2%

: 512-56-1
trimethyl phosphite

: 67-48-1
choline chloride

: 118978-98-6
(2-hydroxyethyl)trimethylammonium dimethyl phosphate

Conditions

Conditions	Yield
With calcium chloride In toluene at 120℃; for 2h;	99%
In methanol at 80℃; for 12h;

: 75-75-2
methanesulfonic acid

: 67-48-1
choline chloride

: N-(2-hydroxyethyl)-N,N,N-trimethylammonium methanesulfonate

Conditions

Conditions	Yield
Stage #1: choline chloride With sodium hydroxide In ethanol at 40℃; for 4h; Stage #2: methanesulfonic acid In ethanol at 0 - 75℃; for 5.5h;	99%

: 67-48-1
choline chloride

: 24801-88-5
3-(triethoxypropyl) isocyanate

: N-{2-(3-triethoxysilylpropyl)carbamoyloxyethyl}-N,N,N-trimethylammonium chloride

Conditions

Conditions	Yield
With dibutyltin dilaurate In acetonitrile at 80℃; for 14h; Inert atmosphere;	98.7%

: 75-44-5
phosgene

: 67-48-1
choline chloride

: 92442-84-7
2-(trimethylammonio)ethyl carbonochloridate chloride

Conditions

Conditions	Yield
In acetone for 16h; Ambient temperature;	98%
In tetrahydrofuran; toluene	88%
In tetrahydrofuran; toluene for 40h;
With chloroform

: 67-48-1
choline chloride

: potassium gibberellate

: choline gibberallate

Conditions

Conditions	Yield
In methanol at 25℃; for 0.5h;	98%

: gallium(III) oxide

: 13598-36-2
phosphonic Acid

: 16898-52-5
1,3-di(piperidin-4-yl)propane

: 67-48-1
choline chloride

: 6153-56-6
oxalic acid dihydrate

: (choline)0.9(4,4'-trimethylenedipiperidinium))0.05[Ga2(HPO3)2(oxalate)(OH)(H2O)]*0.5H2O

Conditions

Conditions	Yield
In water High Pressure; mixt. of diamine, Ga2O3, H3PO3 and choline chloride/oxalic acid (1/1) inH2O was heated in autoclave at 160°C for 1 d;	97%

...Expand

: 67-48-1
choline chloride

: 15307-79-6
diclofenac sodium

: 148439-51-4
(2-hydroxyethyl)tri-methylammonium [o-(2,6-dichloroanilino)phenyl]acetate

Conditions

Conditions	Yield
In ethanol at 20℃; for 1h;	96%

: 67-48-1
choline chloride

: 22767-50-6
sodium heptanesulfonate

: choline heptanesulfonate

Conditions

Conditions	Yield
In chloroform at 20℃; for 5h;	95%

: 67-48-1
choline chloride

: N,N,N-trimethyl-2-(sulfooxy)ethanaminium chloride

Conditions

Conditions	Yield
With chlorosulfonic acid In acetonitrile at 20℃; for 4.25h;	95%
With chlorosulfonic acid In acetonitrile at 5 - 27℃; for 4h;
With chlorosulfonic acid In hexane at 0 - 5℃; for 1.5h;
With chlorosulfonic acid In dichloromethane at 0 - 20℃; for 4h;
With chlorosulfonic acid In acetonitrile at 5℃;

Choline chloride Chemical Properties

Structure of Choline chloride (CAS NO.67-48-1):

IUPAC Name: 2-hydroxyethyl(trimethyl)azanium chloride
Empirical Formula: C₅H₁₄ClNO
Molecular Weight: 139.6238
EINECS: 200-655-4
Melting point: 298-304 ºC
Water solubility: soluble
Sensitive: Hygroscopic
Physical Appearance: White crystalline powder
Product Categories: Quarternary ammonium salts;Ammonium Chlorides (Quaternary);Biochemistry;Quaternary Ammonium Compounds;Vitamin Related Compounds;Vitamins;Antioxidants;Intermediates & Fine Chemicals;Pharmaceuticals
Synonyms of Choline chloride (CAS NO.67-48-1): (2-Hydroxyethyl)trimethylammonium chloride ; (beta-Hydroxyethyl)trimethylammonium chloride ; 2-Hydroxy-N,N,N,-trimethylethanaminium chloride ; Ammonium, (2-hydroxyethyl)trimethyl-, chloride ; Bilineurin chloride ; Biocolina ; Biocoline ; Chloride de choline ; Choline chlorhydrate ; Choline hydrochloride ;
Cholini chloridum ; Cloruro de colina ; Colina cloruro ; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride ; Hepacholine ;
Hormocline ; Lipotril ; Luridin chloride ; Trimethyl(2-hydroxyethyl)ammonium chloride .

Choline chloride Uses

Choline chloride (CAS NO.67-48-1) is an important additive in feed especially for chicken where it accelerates growth and is mass produced . With urea it forms a deep eutectic solvent. Other commercial choline salts are choline bitartrate choline and hydroxide . In foodstuffs the compound is often present as phosphatidylcholine.

Choline chloride Production

In the industrial Davy process choline chloride is produced from ethylene oxide, hydrochloric acid, and trimethylamine,[1] or from the pre-formed salt:

Choline chloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	25mg/kg (25mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog	LDLo	intravenous	5mg/kg (5mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog	LDLo	unreported	1500mg/kg (1500mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse	LD50	intraperitoneal	320mg/kg (320mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse	LD50	intravenous	53mg/kg (53mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse	LD50	oral	3900mg/kg (3900mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse	LDLo	subcutaneous	735mg/kg (735mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 6, Pg. 477, 1914/1915.
rabbit	LDLo	intraperitoneal	500mg/kg (500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.
rabbit	LDLo	intravenous	1100ug/kg (1.1mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit	LDLo	rectal	1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit	LDLo	subcutaneous	1gm/kg (1000mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rat	LD50	intraperitoneal	450mg/kg (450mg/kg)		Indian Journal of Experimental Biology. Vol. 24, Pg. 91, 1986.
rat	LD50	oral	3400mg/kg (3400mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Proceedings of the Society for Experimental Biology and Medicine. Vol. 58, Pg. 87, 1945.

Choline chloride Safety Profile

Hazard Codes: Xi
The Risk Statements information of Choline chloride :
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Choline chloride :
26: In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 1
RTECS: KH2975000
F: 3-9

Product Name

Choline chloride

Synthetic route

Choline chloride Chemical Properties

Choline chloride Uses

Choline chloride Production

Choline chloride Toxicity Data With Reference

Choline chloride Safety Profile

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