-
Name
CONIINE, D/L-(RG)
- EINECS
- CAS No. 458-88-8
- Article Data43
- CAS DataBase
- Density 0.812g/cm3
- Solubility 9.901g/L(25 oC)
- Melting Point ~-2°
- Formula C8H17 N
- Boiling Point 166.2°Cat760mmHg
- Molecular Weight 127.23
- Flash Point 48.4°C
- Transport Information
- Appearance
- Safety Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic effects. When heated to decomposition it emits toxic fumes of NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Coniine(6CI,8CI); Piperidine, 2-propyl-, (S)-; (+)-Coniine; (S)-(+)-Coniine;(S)-2-Propylpiperidine; (S)-Coniine; Cicutin; Cicutine; Conicine; Coniin;Koniin
- PSA 12.03000
- LogP 2.25740
Cicutine Chemical Properties
Empirical Formula: C8H17N
Molecular Weight: 127.2273
EINECS: 207-282-6
Index of Refraction: 1.429
Density: 0.812 g/cm3
Flash Point: 48.4 °C
Enthalpy of Vaporization: 40.27 kJ/mol
Boiling Point: 166.2 °C at 760 mmHg
Vapour Pressure: 1.8 mmHg at 25 °C
Structure of Cicutine (CAS NO.458-88-8):
IUPAC Name of Cicutine (CAS NO.458-88-8): (2S)-2-propylpiperidine
Cicutine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intravenous | 3mg/kg (3mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 316, 1936. | |
| dog | LDLo | intravenous | 25mg/kg (25mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 588, 1948. | |
| frog | LDLo | unreported | 375mg/kg (375mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 595, 1948. |
| guinea pig | LDLo | subcutaneous | 50mg/kg (50mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 593, 1948. |
| mouse | LD50 | intravenous | 19mg/kg (19mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963. |
| mouse | LD50 | oral | 100mg/kg (100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963. |
| mouse | LD50 | subcutaneous | 80mg/kg (80mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963. |
| rabbit | LDLo | intravenous | 15mg/kg (15mg/kg) | "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 588, 1948. | |
| rabbit | LDLo | subcutaneous | 80mg/kg (80mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Medical Sciences, Part 4: Pharmacology. Vol. 7, Pg. 128, 1933. |
Cicutine Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic effects. When heated to decomposition Cicutine (CAS NO.458-88-8) emits toxic fumes of NOx.
Cicutine Specification
Cicutine ,its cas register number is 458-88-8. It also can be called D-2-(n-Propyl)piperidine ; Piperidine, 2-propyl-, (+-)- ; and 2-N-Propylpiperidine .
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