Clevidipine

The Clevidipine, with the CAS registry number 166432-28-6, is also known as Clevidipine butyrate. This chemical's molecular formula is C₂₁H₂₃Cl₂NO₆ and molecular weight is 456.316. Its IUPAC name is called O3-(butanoyloxymethyl) O5-methyl (4R)- 4-(2,3-dichlorophenyl)-2,6-dimethyl- 1,4-dihydropyridine-3,5-dicarboxylate.

Physical properties of Clevidipine: (1)ACD/LogP: 5.46; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 5.46; (4)ACD/LogD (pH 7.4): 5.46; (5)ACD/BCF (pH 5.5): 8354.18; (6)ACD/BCF (pH 7.4): 8361.5; (7)ACD/KOC (pH 5.5): 22324.42; (8)ACD/KOC (pH 7.4): 22343.96; (9)#H bond acceptors: 7; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 10; (12)Index of Refraction: 1.542; (13)Molar Refractivity: 111.45 cm³; (14)Molar Volume: 353.8 cm³; (15)Surface Tension: 44.2 dyne/cm; (16)Density: 1.289 g/cm³; (17)Flash Point: 280.2 °C; (18)Enthalpy of Vaporization: 81.72 kJ/mol; (19)Boiling Point: 539.7 °C at 760 mmHg; (20)Vapour Pressure: 1.03E-11 mmHg at 25°C.

Clevidipine (INN, trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. Cleviprex is a dihydropyridine L-type calcium channel blocker, highly selective for vascular, as opposed to myocardial, smooth muscle and, therefore, has little or no effect on myocardial contractility or cardiac conduction. Cleviprex is rapidly metabolized by esterases in the blood and extravascular tissues. Cleviprex is available in ready-to-use 50- and 100-mL glass vials at a concentration of 0.5 mg/mL of clevidipine butyrate. Vials should be refrigerated at 2-8oC (36-46°F). Cleviprex can be stored to controlled room temperature for up to 2 months.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OCOC(=O)CCC)\C1=C(\N/C(=C(/C(=O)OC)C1c2cccc(Cl)c2Cl)C)C
(2)InChI: InChI=1/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3
(3)InChIKey: KPBZROQVTHLCDU-UHFFFAOYAA