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Name
CLOBAZAM
- EINECS
- CAS No. 22316-47-8
- Article Data14
- CAS DataBase
- Density 1.335g/cm3
- Solubility
- Melting Point 162-164°C
- Formula C16H13 Cl N2 O2
- Boiling Point 643.8°Cat760mmHg
- Molecular Weight 300.744
- Flash Point 343.2°C
- Transport Information
- Appearance
- Safety Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: wakefulness, withdrawal, nausea and vomiting. An experimental teratogen. Other experimental reproductive effects. A tranquilizer. When heated to decomposition it emits very toxic fumes of NOx and Cl−. See also DIAZEPAM.
- Risk Codes 11-23/24/25-39/23/24/25
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Molecular Structure
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Hazard Symbols
- Synonyms Clobazam;Clobazepam; Frisium; Frizium; H 4723; HR 376; LM 2717; Mystan; NSC 336279; Urbadan;Urbanyl
- PSA 40.62000
- LogP 3.50120
Clobazam Chemical Properties
Product Name: Clobazam (CAS NO.22316-47-8)
Molecular Formula: C16H13ClN2O2
Molecular Weight: 300.74g/mol
Mol File: 22316-47-8.mol
Einecs: 244-908-7
Boiling point: 643.8 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 343.2 °C
Density: 1.335 g/cm3
Surface Tension: 52.5 dyne/cm
Enthalpy of Vaporization: 95 kJ/mol
Vapour Pressure: 1.82E-16 mmHg at 25°C
XLogP3-AA: 2.1
H-Bond Donor: 0
H-Bond Acceptor: 2
Product Categories: Active Pharmaceutical Ingredients
Clobazam Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | > 100mg/kg (100mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
| guinea pig | LD50 | oral | 109mg/kg (109mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
| man | TDLo | oral | 104mg/kg/1Y-C (104mg/kg) | BEHAVIORAL: WAKEFULNESS BEHAVIORAL: WITHDRAWAL GASTROINTESTINAL: NAUSEA OR VOMITING | British Medical Journal. Vol. 282, Pg. 1931, 1981. |
| mouse | LD50 | intraperitoneal | 289mg/kg (289mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
| mouse | LD50 | oral | 580mg/kg (580mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 133, 1985. | |
| mouse | LD50 | subcutaneous | 2250mg/kg (2250mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
| rabbit | LD50 | oral | 320mg/kg (320mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
| rat | LD50 | intraperitoneal | 740mg/kg (740mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Clinical Pharmacology. Vol. 7, Pg. 33S, 1979. |
| rat | LD50 | oral | 6gm/kg (6000mg/kg) | Medicamentos de Actualidad. Vol. 16, Pg. 9, 1980. | |
| rat | LD50 | subcutaneous | 8700mg/kg (8700mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE WEAKNESS | Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 663, 1983. |
Clobazam Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: wakefulness, withdrawal, nausea and vomiting. An experimental teratogen. Other experimental reproductive effects. A tranquilizer. When heated to decomposition it emits very toxic fumes of NOx and Cl−. See also DIAZEPAM.
Safety Information of Clobazam (CAS NO.22316-47-8):
Hazard Codes: F
,T
Risk Statements: 11-23/24/25-39/23/24/25
11: Highly Flammable
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
39: Danger of very serious irreversible effects
Safety Statements: 16-36/37-45-24/25-22
16: Keep away from sources of ignition - No smoking
22: Do not breathe dust
24: Avoid contact with skin
25: Avoid contact with eyes
36: Wear suitable protective clothing
37: Wear suitable gloves
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Clobazam Specification
Clobazam ,its CAS NO. is 22316-47-8,the synonyms is 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 7-chloro-1-methyl-5-phenyl- ; 1H-1,5-benzodiazepine-2,4(3H,5H)-dione,7-chloro- ; 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3h-1,5-benzodiazepin ; 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine ; 4(3h,5h)-Dione,7-chloro-1-methyl-5-phenyl-1h-5-benzodiazepine-2 ; Clorepin ; Clobazammethanolsolution .
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