Clopamide supplier | CasNO.636-54-4

Name
Clopamide
EINECS 211-261-7
CAS No. 636-54-4
Density 1.39 g/cm³
Solubility
Melting Point 244-246 °C
Formula C₁₄H₂₀ClN₃O₃S
Boiling Point
Molecular Weight 345.85
Flash Point
Transport Information
Appearance White to yellowish crystalline powder
Safety 36
Risk Codes 42/43
Molecular Structure
Hazard Symbols Xn
Synonyms Benzamide,3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis-;Benzamide,4-chloro-N-(2,6-dimethylpiperidino)-3-sulfamoyl-, cis- (8CI);4-Chloro-N-(cis-2,6-dimethylpiperidino)-3-sulfamoylbenzamide;Adurix;Aquex;Brinaldix;Chlosudimeprimyl;Clopamide;Clopamidum;DT 327;N-(cis-2',6'-Dimethyl-1'-piperidyl)-3-sulfamyl-4-chlorobenzamide;
PSA 100.88000
LogP 4.00500

Clopamide Specification

The IUPAC name of Clopamide is 4-chloro-N-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-3-sulfamoylbenzamide . With the CAS registry number 636-54-4, it is also named as 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide ; Adurix ; Aquex ; Brinaldix ; Chlosudimeprimyl ; Clopamida ; Clopamida [INN-Spanish] ; Clopamidum ; Clopamidum [INN-Latin] ; DT 327 ; UNII-17S83WON0I ; Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis- . This product must store at 2-8 °C. It is soluble in methanol (1:35), ethanol (1:100), chloroform (1:250) and water (1:250).

Clopamide is a piperidine diuretic which is used to treat salidiuretic and antihypertensive. Clopamide is a kind of thiazide drug and it acts in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.

By the research, it was conformed that both clopamide and pindolol are used together, the beta-blocker can probably counterbalance the diuretic-induced negative effects on blood lipids. It is also concluded that treatment with clopamide may induce some changes in Cu and Zn levels in normal hypertensives, particularly in WBCs. Further investigation is needed to determine the extent of this influence.

Product Name

Clopamide

Clopamide Specification

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