Product Name

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  • Name

    CLOTIAZEPAM

  • EINECS 251-627-3
  • CAS No. 33671-46-4
  • Density 1.33 g/cm3
  • Solubility
  • Melting Point 105-106°
  • Formula C16H15 Cl N2 O S
  • Boiling Point 523.7 °C at 760 mmHg
  • Molecular Weight 318.827
  • Flash Point 270.5 °C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. A tranquilizer. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−. See also DIAZEPAM.
  • Risk Codes
  • Molecular Structure Molecular Structure of 33671-46-4 (CLOTIAZEPAM)
  • Hazard Symbols
  • Synonyms 2H-Thieno[2,3-e]-1,4-diazepin-2-one,5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl- (8CI);1-Methyl-5-o-chlorophenyl-7-ethyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one;5-(o-Chlorophenyl)-7-ethyl-1-methyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one;Clotiazepam; Clozan; Rize; Rizen; Tienor; Trecalmo; Veratran; Y 6047
  • PSA 60.91000
  • LogP 3.27830

Clotiazepam Chemical Properties

Product Name: Clotiazepam (CAS NO.33671-46-4)


Molecular Formula: C16H15ClN2OS
Molecular Weight: 318.82g/mol
Mol File: 33671-46-4.mol
Einecs: 251-627-3
Boiling point: 523.7 °C at 760 mmHg
Flash Point: 270.5 °C
Density: 1.33 g/cm3
Surface Tension: 48 dyne/cm
Enthalpy of Vaporization: 79.75 kJ/mol
Vapour Pressure: 4.6E-11 mmHg at 25°C
XLogP3-AA: 3.5
H-Bond Donor: 0
H-Bond Acceptor: 2
IUPAC Name: 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
Canonical SMILES: CCC1=CC2=C(S1)N(C(=O)CN=C2C3=CC=CC=C3Cl)C
InChI: InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19
(2)16(12)21-10/h4-8H,3,9H2,1-2H3 
InChIKey: CHBRHODLKOZEPZ-UHFFFAOYSA-N

Clotiazepam Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 440mg/kg (440mg/kg)   Journal of Medicinal Chemistry. Vol. 16, Pg. 214, 1973.
mouse LD50 oral 636mg/kg (636mg/kg)   Journal of Medicinal Chemistry. Vol. 16, Pg. 214, 1973.
mouse LD50 subcutaneous 2837mg/kg (2837mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
rat LD50 intraperitoneal 682mg/kg (682mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
rat LD50 oral 1461mg/kg (1461mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.

Clotiazepam Safety Profile

Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. A tranquilizer. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−. See also DIAZEPAM.

Clotiazepam Specification

 Clotiazepam ,its CAS NO. is 33671-46-4,the synonyms is 5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one ; 5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one ; BRN 0623332 ; Clotiazepamum ; EINECS 251-627-3 ;  Rizen ; Tienor ; Trecalmo ; UNII-ZCN055599V ; Y 6047 ; 2H-Thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl- .

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