IUPAC Name: [(3R,4S,5R)-5-Hydroxy-6-[2-hydroxy-3-[[4-[[2-hydroxy-7-[(3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-4-oxochromen-3-yl]carbamoyl]-3-methyl-1H-pyrrole-2-carbonyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate
Synonyms of Coumermycin A1 (CAS NO.4434-05-3) : 1H-Pyrrole-2,4-dicarboxamide, N,N'-bis[7-[[6-deoxy-5-C-methyl-4-O-methyl-3-O-[(5-methyl-1H-pyrrol-2-yl)carbonyl]-.alpha.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-3-meth ; 5-Methylpyrrole-2-carboxylic Acid Diester With 3,3'-((3-Methylpyrrole-2,4-diyl)bis(carbonylimino))bis(4-hydroxy-8-methyl-7-((tetrahydro-3,4-dihydroxy-5-methoxy-6,6-dimethylpyran-2-yl)oxy)coumarin) ; 5-Methylpyrrole-2-carboxylic Acid Diester with 3,3'-((3-Methylpyrrole-2,4-diyl)bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl-a-L-lyxopyranosyl)oxy)-4-hydroxy-8-methylcoumarin) ; Coumermycin ; Coumermycin A1
Antibiotics;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics by Application;Chemical Structure Class;Coumarin-glycosidesAntibiotics;Genetic Marker SelectionAntibiotics;Inhibits an EnzymeAntibiotics;Interferes with DNA Synthesis;Mechanism of Action
CAS NO: 4434-05-3
Molecular Formula:C55H59N5O20
Molecular Weight :1110.0785
Molecular Structure :
Index of Refraction:1.684
Surface Tension: 85.4 dyne/cm
Density: 1.54 g/cm3
Solubility: DMSO: 50 mg/mL, clear, faintly yellow
Coumermycin A1 (CAS NO.4434-05-3) is primarily for the treatment of intestinal infection. Ointment for the treatment of skin and wound infections.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intramuscular | 500mg/kg (500mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
mouse | LD50 | intraperitoneal | 159mg/kg (159mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
mouse | LD50 | intravenous | 25mg/kg (25mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
mouse | LD50 | oral | 2gm/kg (2000mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
mouse | LD50 | subcutaneous | 250mg/kg (250mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 786, 1965. |
Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard CodesXn
Risk Statements 22
R22: Coumermycin A1 (CAS NO.4434-05-3) is harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
WGK Germany 3
RTECS UX9375000
F 10-21
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