Product Name

  • Name

    5,12-Naphthacenedione, 10-3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-

  • EINECS
  • CAS No. 88254-07-3
  • Density 1.3397 (rough estimate)
  • Solubility
  • Melting Point
  • Formula C32H34 N2 O12
  • Boiling Point 671.35°C (rough estimate)
  • Molecular Weight 638.68
  • Flash Point 497.6oC
  • Transport Information
  • Appearance
  • Safety Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 88254-07-3 (5,12-Naphthacenedione, 10-3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-)
  • Hazard Symbols
  • Synonyms 5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S,10S)- (9CI); 3'-Deamino-3'-(3-cyano-4-morpholinyl)adriamycin; 3'-Deamino-3'-(3-cyano-4-morpholinyl)doxorubicin;MRA-CN
  • PSA 216.31000
  • LogP 0.20488

Cyanomorpholinoadriamycin Chemical Properties

Product Name: Cyanomorpholinoadriamycin (CAS NO.88254-07-3)


Molecular Formula: C32H34N2O12
Molecular Weight: 638.68g/mol
Mol File: 88254-07-3.mol
Boiling point: 899.2 °C at 760 mmHg
Flash Point: 497.6 °C
Density: 1.59 g/cm3
Surface Tension: 94.6 dyne/cm
Enthalpy of Vaporization: 136.94 kJ/mol
Vapour Pressure: 8.59E-35 mmHg at 25°C
XLogP3-AA: 2
H-Bond Donor: 5
H-Bond Acceptor: 14
Structure Descriptors of Cyanomorpholinoadriamycin (CAS NO.88254-07-3):
  InChI : InChI=1/C32H34N2O12/c1-14-27(37)18(34-6-7-44-13-15(34)11-33)8-22(45-14)46-20-10-32(42,21(36)12-35)9-17-24(20)31(41)26-25(29(17)39)28(38)16-4-3-5-19(43-2)23(16)30(26)40/h3-5,14-15,18,20,22,27,35,37,39,41-42H,6-10,12-13H2,1-2H3   
  Smiles: c12c(C(=O)c3c(C1=O)cccc3OC)c(O)c1c(c2O)C[C@@](C(=O)CO)(O)C[C@@H]1O[C@@H]1C[C@@H]([N@@]2[C@@H](C#N)COCC2)[C@@H]([C@@H](O1)C)O

Cyanomorpholinoadriamycin Toxicity Data With Reference

1.    

mma-sat 500 ng/plate

     CNREA8    Cancer Research. 44 (1984),5599.
2.    

dni-hmn:leu 2200 pmol/L

     CNREA8    Cancer Research. 46 (1986),4041.

Cyanomorpholinoadriamycin Safety Profile

Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Cyanomorpholinoadriamycin Specification

synonyms is 3'-(3-Cyano-4-morpholinyl)-3'-deamino-adriamycin ; 3'-Deamino-3'-(3-cyano-4-morpholinyl)doxorubicin ; BRN 6050053 ; Mra-CN ; NSC 357704 ; 5,12-Naphthacenedione, 10-((3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)- ; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-(3-cyanomorpholino)-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-(hydroxyacetyl)-1-methoxy-6,8,11-trihydroxy-, (8s-cis)- .

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