-
Name
17-(cyclopropylmethyl)morphinan-3-ol
- EINECS
- CAS No. 4163-15-9
- Article Data8
- CAS DataBase
- Density 1.0234 (rough estimate)
- Solubility
- Melting Point 187.5-189°
- Formula C20H27NO
- Boiling Point 438.94°C (rough estimate)
- Molecular Weight 297.44
- Flash Point
- Transport Information
- Appearance
- Safety Poison by intravenous and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms (-)-3-Hydroxy-N-cyclopropylmethylmorphinan;CYCLORPHAN;Morphinan-3-ol,17-(cyclopropylmethyl)-(8CI,9CI);EINECS 224-007-5;17-(Cyclopropylmethyl)morphinan-3-ol;
- PSA 23.47000
- LogP 3.79850
Cyclorphan Chemical Properties
Product Name: Cyclorphan
Synonyms of Cyclorphan (CAS NO.4163-15-9) : (-)-3-Hydroxy-N-cyclopropylmethylmorphinan ;17-(Cyclopropylmethyl)morphinan-3-ol ; Morphinan, (-)-3-hydroxy-N-cyclopropylmethyl- ; Morphinan-3-ol, 17-(cyclopropylmethyl)- (8CI,9CI)
InChI: InChI=1/C20H27NO/c22-16-7-6-15-11-19-17-3-1-2-8-20(17,18(15)12-16)9-10-21(19)13-14-4-5-14/h6-7,12,14,17,19,22H,1-5,8-11,13H2/t17-,19+,20+/m0/s1
Classification Code :Drug / Therapeutic Agent
CAS NO:4163-15-9
Molecular Formula:C20H27NO
Molecular Weight :297.4345
Molecular Structure :.png)
EINECS: 224-007-5
Index of Refraction: 1.63
Surface Tension: 54.1 dyne/cm
Density: 1.19 g/cm3
Flash Point: 232.5 °C
Enthalpy of Vaporization: 74.63 kJ/mol
Boiling Point: 458.4 °C at 760 mmHg
Vapour Pressure: 5.06E-09 mmHg at 25°C
Cyclorphan Uses
Cyclorphan (CAS NO.4163-15-9) is a hallucinogenic opioid mixed agonist-antagonist related to levorphanol discovered in the late 1960s. It is not marketed as an analgesic because of side effects related to its impact on the kappa opioid receptor, but has found some use as a research chemical on and off since its discovery.
Cyclorphan Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 24mg/kg (24mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 112, 1967. | |
| mouse | LD50 | subcutaneous | 215mg/kg (215mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 112, 1967. | |
| rat | LD50 | intravenous | 23mg/kg (23mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 165, Pg. 112, 1967. |
Cyclorphan Safety Profile
Poison by intravenous and subcutaneous routes. When Cyclorphan (CAS NO.4163-15-9) is heated to decomposition ,it emits toxic fumes of NOx.
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