• Name

  D-Ethyl 2-methylbutyrate

• EINECS
• CAS No. 10307-61-6
• Article Data9
• CAS DataBase
• Density 0.879g/cm³
• Solubility
• Melting Point -93.23°C (estimate)
• Formula C7H14 O2
• Boiling Point 135.1°C at 760 mmHg
• Molecular Weight 130.187
• Flash Point 33.4°C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Butanoicacid, 2-methyl-, ethyl ester, (S)-; Butyric acid, 2-methyl-, ethyl ester, (+)-(8CI); (+)-Ethyl 2-methylbutanoate; (+)-Ethyl 2-methylbutyrate; (S)-(+)-Ethyl2-methylbutanoate; (S)-2-Methylbutanoic acid ethyl ester; EthylS-(+)-2-methylbutyrate
• PSA 26.30000
• LogP 1.59560

Synthetic route

C22H25N2O3Pol

141-52-6

sodium ethanolate

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 11h; non-cross-linked polystyrene;	80%

64-17-5

ethanol

1730-91-2

(S)-2-Methylbutyric acid

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

Conditions

Conditions	Yield
With sulfuric acid at 0℃; Inert atmosphere; Molecular sieve; Reflux;	64%
With sulfuric acid In diethyl ether at 30℃; for 2.5h;

1607-30-3

bis-((S)-2-methyl-butyryl)-peroxide

98-07-7

Benzotrichlorid

A

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

B

869-08-9, 108056-48-0, 108056-49-1, 114531-94-1, 114531-96-3

(S)-2-methyl-butyric acid-((S)-sec-butyl ester)

Conditions

Conditions	Yield
at 80℃;

...Expand

5837-78-5

Ethyl tiglate

A

40917-00-8

ethyl (R)-2-methylbutanoate

B

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

Conditions

Conditions	Yield
With hydrogen; N-heterocyclic carbene complex In dichloromethane at 25℃; under 15201 Torr; for 4h; Title compound not separated from byproducts.;

80-59-1

Tiglic acid

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid / 24 h / Reflux; Inert atmosphere 2: hydrogen; [(D)*Ir(1,4-cyclooctadiene)]+[tetrakis(3,5-bis(trifluoromethyl)phenyl)borate]- / dichloromethane / 15 h / 20 °C / 15001.5 Torr / Inert atmosphere View Scheme

5837-78-5

Ethyl tiglate

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

Conditions

Conditions	Yield
With [(D)*Ir(1,4-cyclooctadiene)]+[tetrakis(3,5-bis(trifluoromethyl)phenyl)borate]-; hydrogen In dichloromethane at 20℃; under 15001.5 Torr; for 15h; Inert atmosphere; enantioselective reaction;	n/a

ethyl 2-methyl-2-butenoate

A

40917-00-8

ethyl (R)-2-methylbutanoate

B

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

Conditions

Conditions	Yield
With C38H53IrN3O(1+)*C32H12BF24(1-); hydrogen In dichloromethane at 25℃; under 37503.8 Torr; for 16h; Reagent/catalyst; enantioselective reaction;	A n/a B n/a

1565-80-6

(2S)-2-methyl-1-butanol

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Jones reagent / acetone / 2 h / 0 - 20 °C 2: sulfuric acid / 0 °C / Inert atmosphere; Molecular sieve; Reflux View Scheme

1730-91-2

(S)-2-Methylbutyric acid

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 20 °C 2: potassium hydroxide / 4 h / 60 °C / Inert atmosphere View Scheme

64-17-5

ethanol

(S)-2-(1,2,2-trimethyl-3-cyclopentenyl)-2-oxoethyl (S)-2-methylbutyrate

A

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

B

(S)-hydroxymethyl 1,2,2-trimethyl-3-cyclopentenyl ketone

Conditions

Conditions	Yield
With potassium hydroxide at 60℃; for 4h; Inert atmosphere;

...Expand

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

156-57-0

2-mercaptoethylamine hydrochloride

(S)-2-sec-butyl-4,5-dihydrothiazole

Conditions

Conditions	Yield
Stage #1: 2-mercaptoethylamine hydrochloride With triisobutylaluminum In toluene at 20℃; for 0.5h; Inert atmosphere; Reflux; Stage #2: ethyl (S)-(+)-2-methylbutanoate In toluene for 3h; Reflux;	40%

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

copper chromite

copper chromite

137-32-6

(+/-)-2-methyl-1-butanol

Conditions

Conditions	Yield
at 250℃; under 110326 - 202265 Torr; Racemisierung.Hydrogenation;

609-14-3

2-acetylpropanoic acid ethyl ester

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

(S)-5-hydroxy-2,6-dimethyl-3-oxo-oct-4-enoic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 2-acetylpropanoic acid ethyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere; Stage #2: ethyl (S)-(+)-2-methylbutanoate With n-butyllithium In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere;	0.44 g

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

(S)-5-hydroxy-2,6-dimethyl-3-oxo-oct-4-enoic acid bis potassium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere 1.2: 0.25 h / 0 °C / Inert atmosphere 2.1: potassium hydroxide / ethanol / 3 h / 20 °C View Scheme

10307-61-6

ethyl (S)-(+)-2-methylbutanoate

surugapyrone B

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere 1.2: 0.25 h / 0 °C / Inert atmosphere 2.1: potassium hydroxide / ethanol / 3 h / 20 °C 3.1: trifluoroacetic anhydride / trifluoroacetic acid / 4 h / -20 - 0 °C / Inert atmosphere View Scheme

D-Ethyl 2-methylbutyrate Chemical Properties

D-Ethyl 2-methylbutyrate Specification