D-alpha-Cyclohexylglycine supplier

Name
D-alpha-Cyclohexylglycine
EINECS
CAS No. 14328-52-0
Article Data9
CAS DataBase
Density 1.12 g/cm³
Solubility soluble in water
Melting Point 256 °C
Formula C₈H₁₅NO₂
Boiling Point 292.8 °C at 760 mmHg
Molecular Weight 157.213
Flash Point 130.9 °C
Transport Information
Appearance white powder
Safety 37/39-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Cyclohexaneaceticacid, a-amino-, (R)-;Cyclohexaneaceticacid, a-amino-, D- (8CI);(R)-2-Amino-2-cyclohexylacetic acid;D-Cyclohexylglycine;D-a-Aminocyclohexaneacetic acid;
PSA 63.32000
LogP 1.67890

Synthetic route

: 875-74-1
(R)-phenylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen In water; isopropyl alcohol at 50 - 60℃; for 6 - 8h;	95.8%
With hydrogen; platinum(IV) oxide In acetic acid Ambient temperature;	91%
With hydrogenchloride; hydrogen; rhodium under 38000 Torr; for 240h;	79%
With hydrogenchloride; platinum at 70℃; Hydrogenation;
With hydrogenchloride; hydrogen; platinum(IV) oxide In ethanol

: 5963-46-2, 59759-91-0, 145416-94-0
(R)-benzoylamino-cyclohexyl-acetic acid

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogenchloride

: 2935-35-5
(S)-2-phenylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
(i) aq. HCl, (ii) (hydrogenation); Multistep reaction;

: 14429-43-7
(R)-(acetylamino)-(cyclohexyl)acetic acid

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogen bromide Heating;

: 63546-36-1
(R)-phenylglycine, N-salicylidene derivative

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide

: 54750-25-3
ristomycinic acid

A: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

B: 76249-99-5
(S)-Amino-(3,5-dihydroxy-4-methyl-phenyl)-acetic acid

Conditions

Conditions	Yield
With hydrogen

: 5664-29-9
2-cyclohexylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: quinine 3: aqueous HCl View Scheme
Multi-step reaction with 2 steps 1: acetic acid / (enzymatic racemate resolution) 2: aq. HBr / Heating View Scheme

: 59759-91-0
N-benzoyl-α-cyclohexylglycine

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: quinine 2: aqueous HCl View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 929003-25-8
(R)-2-bromo-2-cyclohexylacetic acid

Conditions

Conditions	Yield
With hydrogen bromide; sodium nitrite In water at 0℃; for 2.5h;	92%

: 24424-99-5
di-tert-butyl dicarbonate

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 70491-05-3
(2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid

Conditions

Conditions	Yield
Stage #1: di-tert-butyl dicarbonate; (R)-2-amino-2-cyclohexyl acetic acid With sodium carbonate In water; acetone at 20℃; for 16h; Stage #2: With potassium hydrogensulfate In water pH=1;	89%
With tetramethyl ammoniumhydroxide	73%

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 85711-13-3
(R)-(-)-2-amino-2-cyclohexylethan-1-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether	82%
With lithium aluminium tetrahydride In tetrahydrofuran for 5h; Heating;	80%
With lithium aluminium tetrahydride In tetrahydrofuran at 20 - 80℃; for 4h;	400 mg
With sodium tetrahydroborate; iodine In tetrahydrofuran at 0℃; for 15h; Reflux;

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 1711-06-4
3-Methylbenzoyl chloride

: (R)-2-cyclohexyl-2-(3-methylbenzamido)acetic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 0℃; for 0.166667h;	50%

: 64-18-6
formic acid

: 7-fluoro-1-(4-{[(2S)-oxiran-2-yl]methyl}piperazin-1-yl)isoquinoline

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: (2R)-cyclohexyl({(2R)-3-[4-(7-fluoroisoquinolin-1-yl)piperazin-1-yl]-2-hydroxypropyl}amino)acetic acid formate

Conditions

Conditions	Yield
Stage #1: 7-fluoro-1-(4-{[(2S)-oxiran-2-yl]methyl}piperazin-1-yl)isoquinoline; (R)-2-amino-2-cyclohexyl acetic acid With N-ethyl-N,N-diisopropylamine In water; isopropyl alcohol at 90℃; for 3h; Stage #2: formic acid	33%

...Expand

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 17609-50-6
(2R)-cyclohexyl glycine ethyl ester

Conditions

Conditions	Yield
With hydrogenchloride; ethanol

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 37763-24-9, 145618-11-7
(R)-amino(cyclohexyl)acetic acid methyl ester

Conditions

Conditions	Yield
With hydrogenchloride; methanol

: 67-56-1
methanol

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 37763-24-9, 145618-11-7
(R)-amino(cyclohexyl)acetic acid methyl ester

Conditions

Conditions	Yield
With thionyl chloride
With thionyl chloride at -20℃; for 18h; Reflux;

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 3116-83-4
sodium salicylate

: (R)-Cyclohexyl-{[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-acetic acid

Conditions

Conditions	Yield
In methanol

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 71989-31-6
Fmoc-Pro-OH

: 76-05-1
trifluoroacetic acid

: 2-(4-Amino-cyclohexylmethyl)-isoindole-1,3-dione

: (S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; compound with trifluoro-acetic acid

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 100929-28-0
(R)-2-(Acetylamino)-2-cyclohexylethanol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 82 percent / LiAlH4 / diethyl ether 2: pyridine / CH2Cl2 / 0 °C 3: KOH / methanol; H2O / 1 h / Heating View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 100929-35-9
Acetic acid (R)-2-acetylamino-2-cyclohexyl-ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 82 percent / LiAlH4 / diethyl ether 2: pyridine / CH2Cl2 / 0 °C View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 100929-31-5
N-((R)-1-Cyclohexyl-2-hydroxy-ethyl)-3-hydroxy-3-phenyl-propionamide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 82 percent / LiAlH4 / diethyl ether 2: pyridine / CH2Cl2 / 0 °C 3: KOH / methanol; H2O / 1 h / Heating 4: BuLi / tetrahydrofuran / 1 h / -78 °C View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: (R)-N-acetyl-α-cyclohexylglycine methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol; hydrogen chloride 2: benzene View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: (R)-acetylamino-cyclohexyl-acetic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol; hydrogen chloride 2: aqueous sodium carbonate View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 145416-93-9
(R)-benzamino-cyclohexyl-acetic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol; hydrogen chloride 2: pyridine View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: (R)-benzamino-cyclohexyl-acetic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol; hydrogen chloride 2: aqueous sodium carbonate View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 14328-68-8
N-Tosyl-S-benzyl-cysteinyl-tyrosyl-(D-2-cyclohexyl-2-amino-essigsaeuremethylester)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 2: (i) aq. HCl, NaNO2, AcOH, Et2O, (ii) /BRN= 3197268/ View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: N-Tosyl-S-benzyl-cysteinyl-tyrosyl-(D-2-cyclohexyl-2-amino-essigsaeurehydrazid)

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: SOCl2 2: (i) aq. HCl, NaNO2, AcOH, Et2O, (ii) /BRN= 3197268/ 3: N2H4*H2O View Scheme

: 1634-04-4
tert-butyl methyl ether

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 304859-69-6
benzyl (2R)-2-amino-2-cyclohexylethanoate methanesulfonate

Conditions

Conditions	Yield
With methanesulfonic acid; benzyl alcohol In toluene	404 g (92%)

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: C18H31NO6

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium carbonate / water; acetone / 16 h / 20 °C 1.2: pH 1 2.1: 4-methyl-morpholine / tetrahydrofuran / -78 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere View Scheme

: 14328-52-0
(R)-2-amino-2-cyclohexyl acetic acid

: 1312306-59-4
(R)-tert-butyl (2-(benzylamino)-1-cyclohexyl-2-oxoethyl)carbamate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium carbonate / water; acetone / 16 h / 20 °C 1.2: pH 1 2.1: 4-methyl-morpholine / tetrahydrofuran / -78 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere 3.1: tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere View Scheme

D-alpha-Cyclohexylglycine Chemical Properties

ProductName: D-Cyclohexylglycine
CAS No.: 14328-52-0
Molecular Formula: C₈H₁₅NO₂
Molecular Weight: 157.21 g/mol
Melting Point: 256 °C
Polar Surface Area: 29.54 Å²
Index of Refraction: 1.51
Molar Refractivity: 42 cm³
Molar Volume: 140.3 cm³
Surface Tension: 47.6 dyne/cm
Enthalpy of Vaporization: 58.57 kJ/mol
Vapour Pressure: 0.000441 mmHg at 25°C
Density: 1.12 g/cm³
Flash Point: 130.9 °C
Boiling Point: 292.8 °C at 760 mmHg
Following is the structure:

The chemical synonymous of D-Cyclohexylglycine (CAS NO.14328-52-0) are (R)-Cyclohexylglycine ; (R)-Amino-cyclohexyl-acetic acid ; R)-(+)-Alpha-aminocyclohexylacetic acid ; R)-Alpha-aminocyclohexylacetic acid ; D-Cyclohexylglycine ; D-Chg;d-2-cyclohexyl-glycine ; D-2-Cyclohexylglycine trifluoroacetate
Product Categories is mainly refer to Peptide.

D-alpha-Cyclohexylglycine Safety Profile

Hazard Codes:
    Xi: Irritant
Risk Statements about D-Cyclohexylglycine (CAS NO.14328-52-0):
    R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements:
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    S37/39 Wear suitable gloves and eye/face protection.

D-alpha-Cyclohexylglycine Specification

1. Storage: Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4°C/39°F.)
2. Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
3. Personal Protection: Eyes: Wear chemical splash goggles.Skin: Wear appropriate protective gloves to prevent skin exposure.Clothing: Wear appropriate protective clothing to prevent skin exposure.Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
4. Fire Fighting: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.

Product Name

D-alpha-Cyclohexylglycine

Synthetic route

D-alpha-Cyclohexylglycine Chemical Properties

D-alpha-Cyclohexylglycine Safety Profile

D-alpha-Cyclohexylglycine Specification

Related Products

Hot Products