Doxepin supplier | CasNO.1668-19-5

Name
DOXEPIN
EINECS
CAS No. 1668-19-5
Article Data15
CAS DataBase
Density 1.122 g/cm³
Solubility readily soluble in water, lower
Melting Point 187-189°C
Formula C19H21 N O
Boiling Point 413.3 °C at 760 mmHg
Molecular Weight 279.382
Flash Point 121.3 °C
Transport Information
Appearance white crystalline solid
Safety Human poison by ingestion. Experimental poison by ingestion, intravenous, and intraperitoneal routes. A sedative and hypnotic used as an antianxiety agent. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes 25
Molecular Structure
Hazard Symbols T
Synonyms Dibenz[b,e]oxepin-D11(6H),g-propylamine, N,N-dimethyl-(7CI,8CI); Dibenz[b,e]oxepin, 1-propanamine deriv.;11-[3-(Dimethylamino)propylidene]-6H-dibenz[b,e]oxepin; Doxepin; Doxepine;N,N-Dimethyldibenz[b,e]oxepin-D11(6H),g-propylamine;NSC 108160
PSA 12.47000
LogP 3.96240

Doxepin Chemical Properties

IUPAC Name: (3Z)-3-(6H-Benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine
The MF of Doxepin (CAS NO.1668-19-5) is C₁₉H₂₁NO.

The MW of Doxepin (CAS NO.1668-19-5) is 279.38.
Synonyms of Doxepin (CAS NO.1668-19-5): (3Z)-3-Dibenzo[b,E]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine ; 11-(3-(Dimethylamino)propylidene)-6H-dibenz(B,E)0xepine
Product Categories: Heterocyclic Compounds;Neurochemicals
Apperance: oil liquid
Index of Refraction: 1.629
Density: 1.122 g/ml
Flash Point: 121.3 °C
Boiling Point: 413.3 °C
Melting Point: 187-189 °C

Doxepin History

Doxepin was synthesized by Stach and Spingler from the German drug manufacturer C. F. Boehringer & Söhne GmbH in Mannheim. It was tested from 1963 to 1968 in different German and Swiss psychiatric institutions and was approved in Germany and elsewhere thereafter. The antidepressive effects were found to be excellent. Strong anxiolytic and sedative properties were also demonstrated. Doxepin has been in clinical use for several decades. The drug plays an important role in many indications today, not only in psychiatry/neurology.

Doxepin Uses

Doxepin (CAS NO.1668-19-5) is antidepressant used clinically to treat anxiety and depression.As doxepin hydrochloride, it is the active ingredient in cream-based preparations (Zonalon and Xepin) for the treatment of dermatological itch. Doxepin is currently investigated for the treatment of insomnia.

Doxepin Production

Triphenyl phosphine and 1,3-dibromo-propane generated 3-bromo-propyl bromide, triphenyl phosphine.To continue with the reaction of anhydrous dimethylamine obtained 3-dimethylamino-propyl bromide, benzene, hydrogen-3 phosphonium salt , and then with the 6,11 - dihydro-dibenzo [b, e] evil G -11 - ketones obtained doxepin. Intermediate 6,11 - dihydro-dibenzo [b, e] evil G -11 - one of the synthetic method can be found in Belg.pat, 641498.

Doxepin Toxicity Data With Reference

1.	orl-hmn LDLo:60 mg/kg	CTOXAO Clinical Toxicology. 10 (1977),327.
2.	orl-rat LD50:147 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 15 (1965),863.
3.	ipr-rat LD50:182 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 15 (1965),863.
4.	ivn-rat LD50:16 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 15 (1965),863.
5.	orl-mus LD50:135 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 15 (1965),863.
6.	ipr-mus LD50:79 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 15 (1965),863.
7.	ivn-mus LD50:26 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 15 (1965),863.
8.	ivn-rbt LD50:11 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 15 (1965),863.

Doxepin Safety Profile

Human poison by ingestion. Experimental poison by ingestion, intravenous, and intraperitoneal routes. A sedative and hypnotic used as an antianxiety agent. When heated to decomposition it emits toxic fumes of NO_x.

Doxepin Specification

Doxepin is a psychotropic agent with tricyclic antidepressant and anxiolytic properties, known under many brand-names such as Aponal, the original preparation by Boehringer-Mannheim, now part of the Roche group; Adapine, Deptran, Sinquan and Sinequan (Pfizer).

Product Name

DOXEPIN