Ethyl 3-bromopropionate supplier

Name
Ethyl 3-bromopropionate
EINECS 208-724-0
CAS No. 539-74-2
Article Data25
CAS DataBase
Density 1.417 g/cm³
Solubility Soluble in water, alcohol, chloroform, benzene.
Melting Point 184-186 °C(Solv: water (7732-18-5))
Formula C₅H₉BrO₂
Boiling Point 179 °C at 760 mmHg
Molecular Weight 181.029
Flash Point 79.4 °C
Transport Information
Appearance clear colorless to pale yellow liquid
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Propionicacid, 3-bromo-, ethyl ester (6CI,7CI,8CI);2-Ethoxycarbonylethyl bromide;3-Bromopropanoic acid ethyl ester;3-Bromopropionic acid ethyl ester;Ethyl3-bromopropanoate;Ethyl 3-bromopropionate;Ethyl b-bromopropionate;NSC 21812;b-Bromopropionic acid ethyl ester;
PSA 26.30000
LogP 1.33450

Synthetic route

: 140-88-5
ethyl acrylate

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With hydrogen bromide In diethyl ether at 0 - 5℃; for 12h;	99%
With diethyl ether; hydrogen bromide erst unter Eiskuehlung, zuletzt bei Raumtemperatur;
With hydrogen bromide
With hydrogen bromide; dibenzoyl peroxide In diethyl ether

: 506-96-7
Acetyl bromide

: 140-88-5
ethyl acrylate

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With hydroquinone In ethanol at 20 - 55℃; for 2h;	91%

: 623-71-2
ethyl 3-chloropropanoate

A: 539-74-2
Ethyl 3-bromopropionate

B: 51070-66-7
2-bromo-2’-chlorodiethyl ether

Conditions

Conditions	Yield
With sodium bromide; 1,2-dibromomethane In N,N-dimethyl-formamide at 100℃; for 6h;	A 85% B n/a

: 64-17-5
ethanol

: 2210-28-8
propyl methacrylate

A: 539-74-2
Ethyl 3-bromopropionate

B: 3-bromo-2-methyl propionic acid n-propyl ester

Conditions

Conditions	Yield
With Acetyl bromide; 2,5-bis(1,1-dimethylethyl)-1,4-benzenediol at 20 - 50℃; for 2h; Overall yield = 11.6 g;	A n/a B 53.4%

...Expand

: 64-17-5
ethanol

A: 539-74-2
Ethyl 3-bromopropionate

B: 3395-91-3
Methyl 3-bromopropionate

Conditions

Conditions	Yield
With Acetyl bromide; hydroquinone; ethyl acrylate at 20 - 50℃; for 2h; Overall yield = 88.5 g;	A n/a B 53%

: 67-56-1
methanol

: 140-88-5
ethyl acrylate

A: 539-74-2
Ethyl 3-bromopropionate

B: 3395-91-3
Methyl 3-bromopropionate

Conditions

Conditions	Yield
With Acetyl bromide; hydroquinone at 20 - 55℃; for 2h; Overall yield = 92.3 g;	A 51% B n/a

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 105-36-2
ethyl bromoacetate

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
Zeitlicher Verlauf unter Belichtung;

: 590-92-1
3-Bromopropionic acid

: 64-17-5
ethanol

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With tetrachloromethane; phenol-2-sulfonic acid und entfernt das entstehende Wasser kontinuierlich mittels einer geeigneten Vorrichtung;
With tetrachloromethane; 5-sulfosalicylic Acid und entfernt das entstehende Wasser kontinuierlich mittels einer geeigneten Vorrichtung;
With sulfuric acid

: 590-92-1
3-Bromopropionic acid

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
durch Veresterung;

: 57-57-8
β-Propiolactone

: 64-17-5
ethanol

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With hydrogen bromide at 2 - 5℃;

: 41330-13-6
cyclopropanone diethyl acetal

A: 539-74-2
Ethyl 3-bromopropionate

B: 3674-13-3
2,3-dibromopropionic acid ethyl ester

Conditions

Conditions	Yield
With tetrachloromethane; bromine

: 98071-69-3
3-bromo-propionimidic acid ethyl ester; hydrobromide

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With water

: 107-13-1
acrylonitrile

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With water; hydrogen bromide Erwaermen des Reaktionsprodukts mit Tetrachlormethan,Aethanol und kleinen Mengen wss.Bromwasserstoffsaeure;

: 27374-25-0
[(1-Ethoxycyclopropyl)oxy]trimethylsilane

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With bromine; titanium tetrachloride 1.) CH2Cl2, 25 deg C, 2.) CH2Cl2; Multistep reaction;

: ethyl 3-(trichlorotitanio)propionate

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With bromine In tetrachloromethane at 0℃;

silver ethyl succinate: silver ethyl succinate

: 539-74-2
Ethyl 3-bromopropionate

Conditions

Conditions	Yield
With tetrachloromethane; bromine

: 539-74-2
Ethyl 3-bromopropionate

: 71962-74-8
Ethyl nipecotate

: 128200-19-1
ethyl 1-[2-(ethoxycarbonyl)ethyl]-3-piperidinecarboxylate

Conditions

Conditions	Yield
With triethylamine In toluene Ambient temperature;	100%

: 539-74-2
Ethyl 3-bromopropionate

: 177171-54-9
di-(2-exo-hydroxy-10-bornyl) diselenide

: 218623-59-7
3-((1S,2R,4R)-2-Hydroxy-7,7-dimethyl-bicyclo[2.2.1]hept-1-ylmethylselanyl)-propionic acid ethyl ester

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol for 4h; Ambient temperature;	100%

: 539-74-2
Ethyl 3-bromopropionate

: 81344-31-2
1,1-dideuterio-3-bromopropanol

Conditions

Conditions	Yield
With lithium aluminium deuteride In tetrahydrofuran at 20℃; for 3h; Reduction;	100%

: 487-89-8
Indole-3-carboxaldehyde

: 539-74-2
Ethyl 3-bromopropionate

: 503829-88-7
3-(3-formyl-indol-1-yl)-propionic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 48h; Heating / reflux;	100%
With potassium carbonate In acetonitrile for 48h; Heating / reflux;	100%
With potassium carbonate In acetonitrile for 48h; Heating / reflux;	100%
With potassium carbonate In acetonitrile for 48h; Heating / reflux;	100%
With potassium carbonate In acetonitrile for 48h;

: 539-74-2
Ethyl 3-bromopropionate

: 1149587-11-0
4-bromo-5-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-3(2H)-one

: 1149587-17-6
ethyl 3-{5-bromo-6-oxo-4-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-1(6H)-yl}propanoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 4h;	100%

: 539-74-2
Ethyl 3-bromopropionate

: 74853-07-9
2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl ]-phenyl]-3H-1,2,4-triazol-3-one

: ethyl 3-(4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)propanoate

Conditions

Conditions	Yield
Stage #1: Ethyl 3-bromopropionate With caesium carbonate In dimethyl sulfoxide at 20℃; for 0.5h; Inert atmosphere; Stage #2: 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl ]-phenyl]-3H-1,2,4-triazol-3-one In dimethyl sulfoxide at 90℃; for 12h; Inert atmosphere;	100%

: 539-74-2
Ethyl 3-bromopropionate

: 100550-00-3
ethyl 3-nitrooxy propionate

Conditions

Conditions	Yield
With silver nitrate In acetonitrile at 70℃; for 5h; Darkness;	99.7%
With silver nitrate; acetonitrile

: 539-74-2
Ethyl 3-bromopropionate

: 1666-13-3
diphenyl diselenide

: 109179-39-7
Ethyl 3-(Phenylseleno)propionate

Conditions

Conditions	Yield
With potassium dihydrogenphosphate; zinc In water; acetonitrile for 1h;	98%
With indium In tetrahydrofuran; water at 25℃; for 5h;	76%
With cerium; iodine 1a) THF, r.t., 30 min, 1b) 35 deg C, 30 min, 2) 25-35-deg C, 5h; Yield given. Multistep reaction;

: 539-74-2
Ethyl 3-bromopropionate

: 81-07-2
saccharin

: 83747-24-4
2-(2'-Ethoxycarbonylethyl)-saccharin

Conditions

Conditions	Yield
With water; potassium carbonate In N,N-dimethyl-formamide for 6h; Heating;	98%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 60 - 80℃; for 4h;

: 900493-69-8
allyl 2-oxo-4-(phenylthio)cyclohex-3-enecarboxylate

: 539-74-2
Ethyl 3-bromopropionate

: 900493-82-5
allyl 1-(3-ethoxy-3-oxopropyl)-2-oxo-4-(phenylthio)cyclohex-3-enecarboxylate

Conditions

Conditions	Yield
Stage #1: allyl 2-oxo-4-(phenylthio)cyclohex-3-enecarboxylate With sodium hydride In tetrahydrofuran for 0.166667h; cooling; Stage #2: Ethyl 3-bromopropionate In tetrahydrofuran at 20℃;	98%

: 539-74-2
Ethyl 3-bromopropionate

: 98-61-3
4-iodobenzenesulfonyl chloride

: ethyl 3-([4-iodophenyl]thio)propanoate

Conditions

Conditions	Yield
Stage #1: p-Iodobenzenesulfonyl chloride With triphenylphosphine In acetonitrile at 60℃; for 0.333333h; Inert atmosphere; Stage #2: Ethyl 3-bromopropionate With potassium carbonate In water; acetonitrile for 20h; Inert atmosphere; Reflux;	98%

: 3770-50-1
2-carbethoxyindole

: 539-74-2
Ethyl 3-bromopropionate

: 256664-26-3
ethyl 1-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 72h; Reflux;	97%
With potassium carbonate In acetonitrile for 144h; Reflux;	1.46 g

: 539-74-2
Ethyl 3-bromopropionate

: 1167415-79-3
7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

: 1167416-62-7
ethyl 3-[7-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]propanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 80℃; Inert atmosphere;	97%

: 539-74-2
Ethyl 3-bromopropionate

: 169298-43-5
N-<2-(3,5-difluoro-4-hydroxyphenylthio)ethyl>phthalimide

: 141286-84-2
{4-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)ethylsulfanyl]-2,6-difluorophenoxy}acetic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 25℃;	97%

: 6320-03-2
2-chlorothiphenol

: 539-74-2
Ethyl 3-bromopropionate

: ethyl 3-(2-chlorophenylthio)propionate

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 80℃; for 1h; Temperature;	97%

: 539-74-2
Ethyl 3-bromopropionate

: 2-(piperidine-4-yl-2H-benzo[d][1,2,3]triazole)

: 1384436-37-6
3-(4-benzotriazol-2-yl-piperidin-1-yl)-propionic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 4h;	96%

: 539-74-2
Ethyl 3-bromopropionate

: 6414-69-3
ethyl 3-iodopropanoate

Conditions

Conditions	Yield
With sodium iodide In butanone at 90℃; for 16h;	95%
With sodium iodide In acetone for 14h; Reflux; Inert atmosphere;	95%
With sodium iodide In acetone 1.) room temperature, 30 min, 2.) reflux, 30 min;	94%

: 5466-88-6
3,4-dihydro-3-oxo-2H-1,4-benzoxazine

: 539-74-2
Ethyl 3-bromopropionate

: 23866-14-0
ethyl 3-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)propanoate

Conditions

Conditions	Yield
Stage #1: 3,4-dihydro-3-oxo-2H-1,4-benzoxazine With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: Ethyl 3-bromopropionate In N,N-dimethyl-formamide at 90℃;	95%
With potassium carbonate In N,N-dimethyl-formamide for 18h; Heating;	91%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h;	45%

: 539-74-2
Ethyl 3-bromopropionate

: 5464-78-8
1-(2-methoxyphenyl)piperazine hydrochloride

: 56968-31-1
ethyl 3-(4-(2-methoxyphenyl)piperazin-1-yl)propanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃;	95%
With potassium carbonate; potassium iodide In acetonitrile for 18h; Heating / reflux;	71%

: 2-(3,4-Dichloro-phenyl)-5-(tetrahydro-pyran-4-yloxy)-pentanenitrile

: 539-74-2
Ethyl 3-bromopropionate

: ammonium chloride

: 4-Cyano-4-(3,4-dichlorophenyl)-7-(tetrahydropyran-4-yloxy)-heptanoic acid ethyl ester

Conditions

Conditions	Yield
With potassium hexamethylsilazane In tetrahydrofuran; toluene	94.4%

...Expand

: 539-74-2
Ethyl 3-bromopropionate

: 116776-59-1
6-(4-Fluoro-phenyl)-4-phenyl-2H-pyridazin-3-one

: 127661-94-3
3-[3-(4-Fluoro-phenyl)-6-oxo-5-phenyl-6H-pyridazin-1-yl]-propionic acid ethyl ester

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 24h; Heating;	94%

: 539-74-2
Ethyl 3-bromopropionate

: 86247-54-3
bis(2-carboxyethylethyl) diselenide

Conditions

Conditions	Yield
With dilithium diselenide In tetrahydrofuran at 5℃; for 0.333333h;	94%

: 539-74-2
Ethyl 3-bromopropionate

: 146395-96-2
2-(3,4-dichloro-phenyl)-5-(tetrahydro-pyran-2-yl-oxy)-pentanenitrile

: 146395-97-3
4-Cyano-4-(3,4-dichloro-phenyl)-7-(tetrahydro-pyran-2-yloxy)-heptanoic acid ethyl ester

Conditions

Conditions	Yield
With potassium hexamethylsilazane In tetrahydrofuran at -78℃;	94%

: 539-74-2
Ethyl 3-bromopropionate

: 81721-87-1
6-nitro-4H-benzo[1,4]oxazin-3-one

: 475469-73-9
3-(6-nitro-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propionic acid ethyl ester

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 40℃; for 0.3h; microwave irradiation;	94%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 10h;	77%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 3h;	65%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h;

: 539-74-2
Ethyl 3-bromopropionate

: 1232540-96-3
6,6'-disulfanediylbis[4-(3,5-dimethylphenoxy)benzene-1,3-diamine]

: 1232541-11-5
C19H24N2O3S

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; ethanethiol In tetrahydrofuran at 20℃; for 0.0166667h;	94%

: 539-74-2
Ethyl 3-bromopropionate

: 536-74-3
phenylacetylene

: 51720-17-3
(4-phenyl-1,2,3-triazole-1-yl)acetic acid ethyl ester

Conditions

Conditions	Yield
With sodium azide; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate In water at 20℃; for 2h; Huisgen Cycloaddition; regiospecific reaction;	94%
With sodium azide; sodium L-ascorbate In water; tert-butyl alcohol for 3h; Heating; Green chemistry;	93%
With sodium azide; sodium L-ascorbate In water at 50℃; for 3.5h; Green chemistry;	91%

: 539-74-2
Ethyl 3-bromopropionate

: 15017-31-9
N’-(pyridin-3-ylmethylene)isonicotinohydrazide

: C22H28N4O5(2+)*2I(1-)

Conditions

Conditions	Yield
With sodium iodide In acetonitrile for 0.0666667h; Microwave irradiation;	94%

: 120-94-5
1-Methylpyrrolidine

: 539-74-2
Ethyl 3-bromopropionate

: 1-(2-Ethoxycarbonyl-ethyl)-1-methyl-pyrrolidinium; bromide

Conditions

Conditions	Yield
In neat (no solvent)	93%

: 539-74-2
Ethyl 3-bromopropionate

: 143-10-2
decylthiol

: 68749-04-2
3-decylsulfanylpropionic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide; acetone at 20℃; for 24h; Alkylation;	93%

Ethyl 3-bromopropionate Chemical Properties

Molecular structure of Propanoic acid,3-bromo-, ethyl ester (CAS NO.539-74-2) is:

Product Name: Propanoic acid,3-bromo-, ethyl ester
CAS Registry Number: 539-74-2
IUPAC Name: Ethyl 3-bromopropanoate
Molecular Weight: 181.02776 [g/mol]
Molecular Formula: C₅H₉BrO₂
XLogP3-AA: 1.2
H-Bond Donor: 0
H-Bond Acceptor: 2
Refractive index: n20/D 1.452(lit.)
Sensitive: Light Sensitive
Surface Tension: 33.7 dyne/cm
Density: 1.417 g/cm³
Flash Point: 79.4 °C
Enthalpy of Vaporization: 41.53 kJ/mol
Boiling Point: 179 °C at 760 mmHg
Vapour Pressure: 0.962 mmHg at 25°C
EINECS: 208-724-0
Product Categories: Pharmaceutical Intermediates;C₂ to C₅;Carbonyl Compounds;Esters

Ethyl 3-bromopropionate Safety Profile

Safty information about Propanoic acid,3-bromo-, ethyl ester (CAS NO.539-74-2) is:
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3

Ethyl 3-bromopropionate Specification

Propanoic acid,3-bromo-, ethyl ester , its cas register number is 539-74-2. It also can be called Ethyl 3-bromopropanoate ; Ethyl 3-bromopropionate ; Ethyl beta-bromopropionate .It is a clear colorless to pale yellow liquid.

Product Name

Ethyl 3-bromopropionate

Synthetic route

Ethyl 3-bromopropionate Chemical Properties

Ethyl 3-bromopropionate Safety Profile

Ethyl 3-bromopropionate Specification

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