Ethyl acetimidate hydrochloride supplier

Name
Ethyl acetimidate hydrochloride
EINECS 218-631-7
CAS No. 2208-07-3
Article Data38
CAS DataBase
Density 0.89g/cm3
Solubility Soluble in water (50mg/L).
Melting Point 112-114 °C(lit.)
Formula C₄H₁₀ClNO
Boiling Point 57.3 °C at 760 mmHg
Molecular Weight 123.582
Flash Point 22.3 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Acetimidicacid, ethyl ester, hydrochloride (6CI,7CI,8CI);Ethanimidic acid, ethyl ester,hydrochloride (9CI);Ethyl acetoamidatehydrochloride;Ethyl acetocarboximidate hydrochloride;Ethyl acetoimidatehydrochloride;Ethyl ethanimidate hydrochloride;Ethyl iminoacetatehydrochloride;
PSA 33.08000
LogP 1.92180

Synthetic route

: 64-17-5
ethanol

: 75-05-8
acetonitrile

: 2208-07-3
ethyl acetimidate hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 0℃; for 0.0833333h; Pinner reaction; Inert atmosphere;	97%
With hydrogenchloride; sulfuric acid at -10 - 35℃; for 8h;	97%
With acetyl chloride at 0℃; for 12h; Pinner Imino Ether Synthesis; Large scale;	95%

: 64-17-5
ethanol

: 73233-19-9, 90586-61-1
acetonitrile*2hydrogen chloride

: 2208-07-3
ethyl acetimidate hydrochloride

Conditions

Conditions	Yield
at -16℃;

: 60-35-5
acetamide

: 541-41-3
chloroformic acid ethyl ester

: 2208-07-3
ethyl acetimidate hydrochloride

: 7647-01-0
hydrogenchloride

: 64-17-5
ethanol

: 75-05-8
acetonitrile

: 2208-07-3
ethyl acetimidate hydrochloride

...Expand

: 75-36-5
acetyl chloride

: 75-05-8
acetonitrile

: 2208-07-3
ethyl acetimidate hydrochloride

Conditions

Conditions	Yield
In methanol; tert-butyl methyl ether at 0℃; for 3.5h;	13 g

: methyl 2,6-diamino-2-methylhex-4-ynoate, dihydrochloride

: 2208-07-3
ethyl acetimidate hydrochloride

: 404860-60-2
methyl 2-amino-6-(ethanimidoylamino)-2-methylhex-4-ynoate

Conditions

Conditions	Yield
Stage #1: methyl 2,6-diamino-2-methylhex-4-ynoate, dihydrochloride With sodium hydroxide In water at 25℃; for 0.166667h; pH=~ 7.95; Stage #2: ethyl acetimidate hydrochloride With sodium hydroxide In water for 3h; pH=8 - 8.5; Stage #3: With hydrogenchloride In water pH=4.1;	100%
Stage #1: methyl 2,6-diamino-2-methylhex-4-ynoate, dihydrochloride; ethyl acetimidate hydrochloride With sodium hydroxide In water for 3.16667h; pH=7.95 - 8.5; Stage #2: With hydrogenchloride In water pH=4.1;	100%

: 945217-60-7
tert-butyl (3R,4S)-3,4-diaminopyrrolidine-1-carboxylate

: 2208-07-3
ethyl acetimidate hydrochloride

: 1202067-52-4
cis-(3,6)-2-methyl-3a,4,6,6a-tetrahydro-1H-pyrrolo[3.4-d]imidazole-5-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
In ethanol at 80℃; for 2.5h;	100%

: 68076-36-8
1-amino-4-[(tert-butyloxycarbonyl)amino]butane

: 2208-07-3
ethyl acetimidate hydrochloride

: 76-05-1
trifluoroacetic acid

: tert-butyl N-[4-(ethanimidoylamino)butyl]carbamate trifluoroacetate

Conditions

Conditions	Yield
Stage #1: 1-amino-4-[(tert-butyloxycarbonyl)amino]butane; ethyl acetimidate hydrochloride With triethylamine at 20℃; Inert atmosphere; Cooling with ice; Stage #2: trifluoroacetic acid	100%

...Expand

: 2208-07-3
ethyl acetimidate hydrochloride

: ethyl (2S)-3-(7-amidino-2-naphthyl)-2-<4-<(3S)-3-pyrrolidinyloxy>phenyl>propanoate dihydrochloride

: ethyl (2S)-2-<4-<<(3S)-1-acetimidoyl-3-pyrrolidinyl>oxy>phenyl>3-(7-amidino-2-naphthyl)propanoate dihydrochloride

Conditions

Conditions	Yield
With triethylamine at 5℃; for 2.5h;	99.1%

: 21436-03-3
(S,S)-1,2-diaminocyclohexane

: 2208-07-3
ethyl acetimidate hydrochloride

: (3aS,7aS)-2-methyl-3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazole

Conditions

Conditions	Yield
In ethanol at 0 - 20℃; for 8h; Inert atmosphere;	99%
In ethanol at 0 - 20℃;
In ethanol at 20℃; for 9h;

: 2208-07-3
ethyl acetimidate hydrochloride

: 868-59-7
L-cysteine ethyl ester hydrochloride

: 89530-18-7
ethyl 2-methyl-2-thiazoline-(4R)-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	98%
With triethylamine In dichloromethane at 0℃; Condensation;	85%

: 2208-07-3
ethyl acetimidate hydrochloride

: 103-80-0
phenylacetyl chloride

: 107465-70-3
ethyl N-phenylacetylacetimidate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.5h;	98%

: 29841-69-8
(S,S)-1,2-diphenyl-1,2-diaminoethane

: 2208-07-3
ethyl acetimidate hydrochloride

: 109830-48-0, 133815-21-1
(4S,5S)-2-methyl-4,5-diphenyl-4,5-dihydro-1H-imidazole

Conditions

Conditions	Yield
In ethanol at 0 - 20℃; for 12h; Inert atmosphere;	98%

: 2208-07-3
ethyl acetimidate hydrochloride

: C14H22N2O

: C16H25N3O*ClH

Conditions

Conditions	Yield
In ethanol Cooling with ice;	98%

: 713511-21-8
2-amino-4-(3-fluoro-benzyloxy)-benzoic acid

: 2208-07-3
ethyl acetimidate hydrochloride

: 713511-22-9
7-(3-fluoro-benzyloxy)-2-methyl-3H-quinazolin-4-one

Conditions

Conditions	Yield
With sodium methylate In methanol for 20h; Heating / reflux;	97%

: 3-amino-5-ethyl-4-(3-pentyl)pyrazole

: 2208-07-3
ethyl acetimidate hydrochloride

A 3-acetamidino-5-ethyl-4-(3-pentyl)pyrazole, hydrochloride salt: 3-acetamidino-5-ethyl-4-(3-pentyl)pyrazole, hydrochloride salt

B: 4-phenyl-8-(3-pentyl)-7-ethyl-2-methyl-pyrazolo[1,5-a]-1,3,5-triazine

Conditions

Conditions	Yield
With potassium carbonate; acetic acid In water; acetonitrile	A n/a B 96%

...Expand

: 420-04-2
CYANAMID

: 2208-07-3
ethyl acetimidate hydrochloride

: 1558-82-3
ethyl N‐cyanoethanimidate

Conditions

Conditions	Yield
With disodium hydrogenphosphate In water at 40℃; for 4h;	95.3%
With disodium hydrogenphosphate

: 2208-07-3
ethyl acetimidate hydrochloride

: 879-18-5
naphthalene-1-carbonic acid chloride

: 130168-80-8
Naphthalene-1-carboxylic acid [1-ethoxy-eth-(Z)-ylidene]-amide

Conditions

Conditions	Yield
In toluene for 40h; Ambient temperature;	95%

: 18903-44-1
2-amino-2,2-diphenyl-ethanol

: 2208-07-3
ethyl acetimidate hydrochloride

: 4,4-diphenyl-2-methyl-1,3-oxazolin

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In chloroform for 12h; Reflux;	95%
In dichloromethane at 20℃;	63%

: 2208-07-3
ethyl acetimidate hydrochloride

: 823-94-9
2,4,6-trimethyl-s-triazine

Conditions

Conditions	Yield
Stage #1: ethyl acetimidate hydrochloride With potassium carbonate In dichloromethane; water Stage #2: With acetic acid at 20 - 30℃; for 17.5h;	95%
Stage #1: ethyl acetimidate hydrochloride With potassium carbonate Stage #2: With acetic acid
Stage #1: ethyl acetimidate hydrochloride With potassium carbonate In dichloromethane; water at 20 - 25℃; Stage #2: With acetic acid at 25℃; for 25h;

: 2208-07-3
ethyl acetimidate hydrochloride

: 128162-92-5
8-Phenylmenthyl (2S,3S)-3-Amino-2-hydroxy-5-methyl-hexanoate

: 128162-93-6
(4S,5S)-4-Isobutyl-2-methyl-4,5-dihydro-oxazole-5-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 6h;	94%

: 2208-07-3
ethyl acetimidate hydrochloride

: 128114-54-5
(-)-8-Phenylmenthyl (2S,3R)-3-Amino-2-hydroxy-5-methyl-hexanoate

: 128114-55-6
(4R,5S)-4-Isobutyl-2-methyl-4,5-dihydro-oxazole-5-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 6h;	94%

: 2208-07-3
ethyl acetimidate hydrochloride

: 129884-37-3, 782445-78-7
cis-4,5-diaminocyclohexene

: 129884-40-8
(3aR,7aS)-2-Methyl-3a,4,7,7a-tetrahydro-1H-benzoimidazole; hydrochloride

Conditions

Conditions	Yield
In ethanol at 85℃; for 15h;	93%

: 23190-16-1
(1R,2S)-2-Amino-1,2-diphenylethanol

: 2208-07-3
ethyl acetimidate hydrochloride

: 474669-82-4
(4S,5R)-2-methyl-4,5-diphenyl-4,5-dihydrooxazole

Conditions

Conditions	Yield
In dichloromethane at 20℃;	93%

: 2208-07-3
ethyl acetimidate hydrochloride

: 114811-78-8
N-<β-4-hydroxy-3,5-di-tert-butylphenyl)propionyl>guanidine

: 114811-79-9
2-amino-4-methyl-6-<β-(4-hydroxy-3,5-di-tert-butylphenyl)ethyl>-sym-triazine

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	92%

: 35132-20-8
(R,R)-1,2-diphenylethylenediamine

: 2208-07-3
ethyl acetimidate hydrochloride

: 320778-88-9
(+)-(4R,5R)-2-methyl-4,5-diphenyl-4,5-dihydro-1H-imidazole

Conditions

Conditions	Yield
In ethanol at 20℃; for 10h;	92%

: 20989-17-7
(2S)-2-phenylglycinol

: 2208-07-3
ethyl acetimidate hydrochloride

: 222622-39-1
(4S)-4,5-dihydro-2-methyl-4-phenyl-1,3-oxazole

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 15h; Inert atmosphere; Schlenk technique;	92%
In dichloromethane at 20℃;	68%
In dichloromethane at 0 - 40℃; for 16h;

: 2208-07-3
ethyl acetimidate hydrochloride

: 108467-99-8
1-(N-Boc-aminomethyl)-3-(aminomethyl)benzene

: N-(3-(N-Boc-aminomethyl)benzyl)acetimidine hydrochloride

Conditions

Conditions	Yield
In ethanol at 0℃; for 3h;	92%

: ethyl N-[3-(3-amidinophenyl)-2-(E)-propenyl]-N-[5-carbamoyl-2-methyl-4-(piperidin-4-yloxy)phenyl]sulfamoylacetate dihydrochloride

: 2208-07-3
ethyl acetimidate hydrochloride

: 75-05-8
acetonitrile

: Ethyl N-[4-(1-acetimidoylpiperidin-4-yloxy)-5-carbamoyl-2-methylphenyl]-N-[3-(3-amidinophenyl)-2-(E)-propenyl]sulfamoylacetate dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; triethylamine In 1,4-dioxane; ethanol	92%

...Expand

: 56613-80-0
(R)-Phenylglycinol

: 2208-07-3
ethyl acetimidate hydrochloride

: 116173-81-0
(R)-2-methyl-4-phenyl-Δ2-oxazoline

Conditions

Conditions	Yield
	91%
Cyclization;

: 2208-07-3
ethyl acetimidate hydrochloride

: 3619-22-5
p-toluic hydrazide

: 1314991-79-1
4-methyl-benzoic acid (1-imino-ethyl)hydrazide

Conditions

Conditions	Yield
With sodium In ethanol at 20℃;	91%

: 2208-07-3
ethyl acetimidate hydrochloride

: 3619-22-5
p-toluic hydrazide

: 210179-03-6
4-methyl-benzoic acid N'-(1-imino-ethyl)-hydrazide

Conditions

Conditions	Yield
Stage #1: ethyl acetimidate hydrochloride With sodium In ethanol at 20℃; Stage #2: p-toluic hydrazide In ethanol	91%
Stage #1: ethyl acetimidate hydrochloride With ethanol; sodium at 20℃; Stage #2: p-toluic hydrazide at 20℃;	91%

: 2208-07-3
ethyl acetimidate hydrochloride

: 62465-90-1
methyl (N-(4-chlorophenyl)hydrazono)chloroacetate

: 933221-18-2
1-(4-chlorophenyl)-3-methoxycarbonyl-5-methyl-1,2,4-triazole

Conditions

Conditions	Yield
With triethylamine In toluene for 2h; Reflux;	91%

Ethyl acetimidate hydrochloride Chemical Properties

Molecular Structure of Ethanimidic acid, ethylester, hydrochloride (1:1) (CAS NO.2208-07-3):

IUPAC Name: ethyl ethanimidate hydrochloride
Empirical Formula: C₄H₁₀ClNO
Molecular Weight: 123.5813
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 2
Polar Surface Area: 12.24Å²
Flash Point: 22.3 °C
Enthalpy of Vaporization: 28.76 kJ/mol
Boiling Point: 57.3 °C at 760 mmHg
Vapour Pressure: 232 mmHg at 25°C
Melting point: 112-114 °C(lit.)
Storage temp: 2-8°C
Sensitive: Moisture Sensitive
BRN: 3552401
InChI
InChI=1/C4H9NO.ClH/c1-3-6-4(2)5;/h5H,3H2,1-2H3;1H
Smiles
[NH2+]=C(OCC)C.[ClH-]
EINECS: 218-631-7
Product Categories: Amidates/Imidates; Nitrogen Compounds; Organic Building Blocks

Ethyl acetimidate hydrochloride Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3
F: 3-10-21

Ethyl acetimidate hydrochloride Specification

Ethanimidic acid, ethylester, hydrochloride (1:1) , with CAS number of 2208-07-3, can be called 1-Ethoxyethaniminium chloride ; Ethyl ethanimidoate hydrochloride (1:1) . It is a white to light yellow crystal powder.

Product Name

Ethyl acetimidate hydrochloride

Synthetic route

Ethyl acetimidate hydrochloride Chemical Properties

Ethyl acetimidate hydrochloride Safety Profile

Ethyl acetimidate hydrochloride Specification

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