Ethyl (R)-3-hydroxybutyrate supplier

Name
Ethyl (R)-3-hydroxybutyrate
EINECS
CAS No. 24915-95-5
Article Data185
CAS DataBase
Density 1.025 g/cm³
Solubility soluble
Melting Point
Formula C₆H₁₂O₃
Boiling Point 174.999 °C at 760 mmHg
Molecular Weight 132.159
Flash Point 64.444 °C
Transport Information
Appearance clear colorless liquid
Safety 24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Butanoicacid, 3-hydroxy-, ethyl ester, (R)-;Butyric acid, 3-hydroxy-, ethyl ester,(-)- (8CI);(-)-Ethyl 3-hydroxybutyrate;(3R)-3-Hydroxybutanoic acid ethylester;(R)-(-)-Ethyl 3-hydroxybutyrate;(R)-3-Hydroxybutanoic acid ethyl ester;(R)-3-Hydroxybutyric acid ethyl ester;(R)-Ethyl 3-hydroxybutanoate;(R)-Ethyl3-hydroxybutyrate;(R)-Ethyl b-hydroxybutyrate;D-3-Hydroxybutyric acid ethyl ester;Ethyl (-)-b-hydroxybutyrate;
PSA 46.53000
LogP 0.32040

Synthetic route

: 141-97-9
ethyl acetoacetate

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With (S)-4,12-bis(diphenylphosphino)-<2.2>paracyclophane-Ru(II)bis(trifluoroacetate); hydrogen; tetra-(n-butyl)ammonium iodide In methanol; water at -5℃; under 2585.7 Torr; for 18h;	100%
With hydrogen; Ru(R-Xyl-P-Phos)(C6H6)Cl2 In ethanol; dichloromethane at 70℃; under 10343 Torr; for 1h;	100%
With [(+)-N,N'-Me2-3,3'-(Ph2P)2-1,1'-biindole]RuCl2; hydrogen In methanol; water at 45℃; under 79805.4 Torr; for 0.5h;	100%

: 5405-41-4
ethyl 3-hydroxybutyrate

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With alcohol dehydrogenase from Thermoanaerobium brockii; NADH-specific (R)-selective-ADH; YcnD-oxidoreductase at 30℃; for 24h; pH=7.5; aq. buffer; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantiospecific reaction;	99%

: 1006696-12-3
(R)-ethyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sodium perborate In tetrahydrofuran; water at 20℃;	94%
With sodium peroxoborate tetrahydrate In tetrahydrofuran; water at 20℃; for 3h;	84%
With sodium perborate tetrahydrate In tetrahydrofuran; water Inert atmosphere;

: 141-97-9
ethyl acetoacetate

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 56816-01-4
ethyl (S)-3-hydroxybutyrate

Conditions

Conditions	Yield
With citrate-phosphate-borate buffer for 24h; Ambient temperature; baker's yeast immobilized in calcium alginate; Title compound not separated from byproducts;	A n/a B 85%
With Convolvulus sepium for 120h; pH=5.8; aq. phosphate buffer; optical yield given as %ee;	A n/a B 70%
yeast Conversion of starting material; Enzymatic reaction;	A n/a B 26%

: 64-17-5
ethanol

PHB/PHV biopolymer: PHB/PHV biopolymer

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 54074-85-0, 73143-67-6, 122673-73-8, 73143-60-9
ethyl (3R)-hydroxyvalerate

Conditions

Conditions	Yield
With sulfuric acid In 1,2-dichloro-ethane for 48h; Heating;	A 84% B 59%

...Expand

poly-(3(R)-hydroxy butyric acid: poly-(3(R)-hydroxy butyric acid

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid In ethanol Heating;	83%

: 64-17-5
ethanol

poly((R)-hydroxybutanoate): poly((R)-hydroxybutanoate)

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid In 1,2-dichloro-ethane Heating;	82%

: 64-17-5
ethanol

poly-(R)-3-hydroxybutyrate: poly-(R)-3-hydroxybutyrate

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid In 1,2-dichloro-ethane for 75h; Reflux;	81%

poly-β-hydroxybutyrate (PHB): poly-β-hydroxybutyrate (PHB)

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid In ethanol; 1,2-dichloro-ethane for 37h; Heating; Irradiation;	80%

: 64-17-5
ethanol

poly-3(R)-hydroxybutyrate: poly-3(R)-hydroxybutyrate

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid In 1,2-dichloro-ethane for 96h; Heating;	71%

: 64-17-5
ethanol

: 32082-74-9
(R)-4-methyloxetan-2-one

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid at 20℃;	66%
With sulfuric acid

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 372-30-5, 85571-85-3, 88968-78-9, 99437-70-4
ethyl (3S)-4,4,4-trifluoro-3-hydroxybutanoate

C: 85571-85-3
ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate

Conditions

Conditions	Yield
With Fala baker' yeast; allyl alcohol Microbiological reaction;	A 62% B n/a C n/a

...Expand

: 64-17-5
ethanol

poly-[(R)-3-hydroxybutyric] acid: poly-[(R)-3-hydroxybutyric] acid

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid In 1,2-dichloro-ethane for 48h;	60%

: ethyl (R)-3-(((2,2,2-trichloroethoxy)carbonyl)oxy)butanoate

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With trimethyltin(IV) hydroxide In 1,2-dichloro-ethane at 60℃; for 10h; Inert atmosphere; chemoselective reaction;	58%

: 141-97-9
ethyl acetoacetate

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 29267-46-7
3,3-bismethoxybutyric acid methyl ester

Conditions

Conditions	Yield
With <(+)-2,2'-bis(diphenylphosphino)-4,4',6,6'-tetramethyl-3,3'-bibenzothiophene>RuCl2; hydrogen In methanol at 70℃; under 73550.8 Torr; for 2h; Yield given;	A n/a B 5%

: 64-17-5
ethanol

: 625-72-9
(R)-3-hydroxybutyric acid

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid

: 5405-41-4
ethyl 3-hydroxybutyrate

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 56816-01-4
ethyl (S)-3-hydroxybutyrate

Conditions

Conditions	Yield
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With pentyl cage-coated capillary column Resolution of racemate;
With homochiral metal-organic cage [Zn3(deprotonated [3+3] macrocyclic Schiff base of trans-1,2-diaminocyclohexane and 4-tert-butyl-2,6-diformylphenol)2] coated capillary column In dichloromethane at 118℃; Resolution of racemate; enantioselective reaction;

: 141-97-9
ethyl acetoacetate

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 625-72-9
(R)-3-hydroxybutyric acid

C: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

D: 56816-01-4
ethyl (S)-3-hydroxybutyrate

Conditions

Conditions	Yield
With Halobacterium halobium; pepton; potassium chloride; water; sodium citrate; magnesium sulfate; sodium chloride at 40℃; for 120h; Irradiation; Yields of byproduct given. Title compound not separated from byproducts;
With Halobacterium halobium; pepton; potassium chloride; sodium citrate; magnesium sulfate; sodium chloride In water at 40℃; for 120h; Irradiation; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 100009-46-9
ethyl 3-nitro-oxy-butanoate

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 56816-01-4
ethyl (S)-3-hydroxybutyrate

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 56816-01-4
ethyl (S)-3-hydroxybutyrate

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid 2.) MeOH, 1 h, room temperature; Yield given;

: 2-((R)-1-Hydroxy-ethyl)-[1,3]dithiolane-2-carboxylic acid ethyl ester

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sodium tetrahydroborate; hydrogen; nickel dichloride for 16h; Ambient temperature; Yield given;

: 64-17-5
ethanol

poly(R)-3-hydroxybutanoic acid (PHB): poly(R)-3-hydroxybutanoic acid (PHB)

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid

: 64-17-5
ethanol

poly-(R)-3-hydroxybuttersaeure: poly-(R)-3-hydroxybuttersaeure

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With sulfuric acid 1.) 1,2-dichloroethane, reflux, 2 h; 2.) reflux, 48 h; Yield given. Multistep reaction;

: 372-31-6
ethyl 4,4,4-trifluoroacetoacetate

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 372-30-5, 85571-85-3, 88968-78-9, 99437-70-4
ethyl (3S)-4,4,4-trifluoro-3-hydroxybutanoate

C: 141-97-9
ethyl acetoacetate

D: 85571-85-3
ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate

Conditions

Conditions	Yield
With Fala baker' yeast; allyl alcohol

...Expand

poly-(R)-(-)-3-hydroxybutyrate: poly-(R)-(-)-3-hydroxybutyrate

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
With hydrogenchloride; ethanol In 1,2-dichloro-ethane for 12h; Heating;	0.93 g

: 64-17-5
ethanol

poly[(R)-hydroxybutyrate] BIOPOL D300G: poly[(R)-hydroxybutyrate] BIOPOL D300G

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 54074-85-0, 73143-67-6, 122673-73-8, 73143-60-9
ethyl (3R)-hydroxyvalerate

Conditions

Conditions	Yield
Stage #1: poly[(R)-hydroxybutyrate] BIOPOL D300G In dichloromethane at 83℃; for 2h; Stage #2: ethanol With sulfuric acid In dichloromethane for 71h; Heating; Title compound not separated from byproducts;

...Expand

: 123-73-9
trans-Crotonaldehyde

: 64-17-5
ethanol

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 56816-01-4
ethyl (S)-3-hydroxybutyrate

Conditions

Conditions	Yield
Stage #1: trans-Crotonaldehyde; ethanol With dihydrogen peroxide In chloroform at -20℃; for 16h; Stage #2: With N-ethyl-N,N-diisopropylamine In chloroform at 30℃; for 15h; Further stages. Title compound not separated from byproducts.;

...Expand

: 100009-40-3
ethyl (S)-3-tosyloxy-butanoate

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / (n-Bu4)N(1+)*NO3(1-) / benzene / 6 h / Heating 2: H2 / Pd/C / methanol View Scheme

: 123-54-6
acetylacetone

A: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

B: 56816-01-4
ethyl (S)-3-hydroxybutyrate

Conditions

Conditions	Yield
With D-glucose In phosphate buffer at 30℃; for 12h; pH=7; Title compound not separated from byproducts.;

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 109715-46-0
ethyl (R)-3-[(tert-butyldimethylsilyl)oxy]butanoate

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 0℃;	100%
With 1H-imidazole In dichloromethane	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;	100%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 109-92-2
ethyl vinyl ether

: (R)-3-(2-Ethoxy-ethoxy)-butyric acid ethyl ester

Conditions

Conditions	Yield
trifluoroacetic acid	100%

: 110-87-2
3,4-dihydro-2H-pyran

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 90410-58-5
(3R,2'RS)-3-<(Tetrahydropyran-2'-yl)oxy>buttersaeure-ethylester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 0℃; for 0.25h;	100%
With toluene-4-sulfonic acid In diethyl ether	100%
With pyridinium p-toluenesulfonate In dichloromethane at 0 - 20℃; for 24h; Inert atmosphere; Schlenk technique;	91%
With toluene-4-sulfonic acid

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 183310-90-9
(R)-3-(tert-butyl-diphenyl-silanyloxy)-butyraldehyde

Conditions

Conditions	Yield
Stage #1: Ethyl (R)-3-hydroxybutanoate; tert-butylchlorodiphenylsilane With 1H-imidazole; dmap In dichloromethane Stage #2: With diisobutylaluminium hydride In dichloromethane at -78℃; Further stages.;	100%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 109-92-2
ethyl vinyl ether

: 79414-11-2, 79414-12-3, 82614-86-6
ethyl-3-(1-ethoxyethoxy)-butanoate

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane for 1h; Ambient temperature;	99%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 147963-63-1
ethyl (R)-3-(tert-butyldiphenylsilyloxy)butyrate

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide	99%
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃;	99%
With 1H-imidazole In N,N-dimethyl-formamide for 72h; Ambient temperature;	96%
With 1H-imidazole In N,N-dimethyl-formamide for 3h; Ambient temperature;	95%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 6h;	80%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 124-63-0
methanesulfonyl chloride

: 126434-58-0
(-)-(R)-Ethyl 3-(mesyloxy)butanoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	99%
With triethylamine In dichloromethane at 0℃; for 1h;	97%
With triethylamine In dichloromethane	75%

: 67-56-1
methanol

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 3976-69-0
Methyl (R)-3-hydroxybutyrate

Conditions

Conditions	Yield
scandium tris(trifluoromethanesulfonate) at 64℃; for 10h;	98%
(EtO)3TiO(CH2)2OTi(OEt)3 autoclave, 1.) 160 deg C, 17 bar, 2 h; 2.) 115 deg C, 3.5 bar, 27 h;	82%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 994-30-9
triethylsilyl chloride

: ethyl (R)-3-((triethylsilyl)oxy)butanoate

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; for 18h;	96%
With 1H-imidazole In dichloromethane

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 98-59-9
p-toluenesulfonyl chloride

: 121404-60-2
(-)-(R)-Ethyl 3-<(p-tolylsulfonyl)oxy>butanoate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 12h;	95%
With pyridine In chloroform at 0℃; for 12h;	71%
With pyridine at 0℃; for 24h;	22.1 g

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 69739-34-0
t-butyldimethylsiyl triflate

: 109715-46-0
ethyl (R)-3-[(tert-butyldimethylsilyl)oxy]butanoate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine In dichloromethane at 0 - 20℃; for 2.5h;	95%
With pyridine In dichloromethane at 0 - 20℃;	62%
With pyridine Etherification;

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 107-30-2
chloromethyl methyl ether

: 272125-68-5
(R)-ethyl 3-(methoxymethoxy)butanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	95%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Etherification;	86%
With N-ethyl-N,N-diisopropylamine In dichloromethane	75%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 386707-15-9
methyl 3'-(cyanocarbonyl)-2,2'-binaphthalene-3-carboxylate

: (R)-4-ethoxy-4-oxobutan-2-yl methyl 2,2'-binaphthalene-3,3'-dicarboxylate

Conditions

Conditions	Yield
With dmap In acetonitrile at 20℃; for 2h;	95%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 74-88-4
methyl iodide

: 27372-03-8, 51898-35-2, 51898-36-3, 63647-69-8, 78088-27-4, 78088-28-5, 86853-34-1, 92282-67-2, 86853-33-0
ethyl anti-(2R,3R)-2-methyl-3-hydroxybutanoate

Conditions

Conditions	Yield
Stage #1: Ethyl (R)-3-hydroxybutanoate With n-butyllithium; diisopropylamine In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane at -78 - -40℃; for 0.333333h; Frater-Seebach alkylation; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane at -78 - 0℃; Frater-Seebach alkylation; Inert atmosphere; enantioselective reaction;	94%
Stage #1: Ethyl (R)-3-hydroxybutanoate With lithium diisopropyl amide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane at -78 - -40℃; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane at -78 - 0℃; for 2h; Inert atmosphere;	92%
With lithium diisopropyl amide In tetrahydrofuran at -78℃;	84%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 625-72-9
(R)-3-hydroxybutyric acid

Conditions

Conditions	Yield
With potassium hydroxide at 0℃; for 24h;	93%
With sodium hydroxide In water at 10℃; for 6h;	85%
With potassium hydroxide for 12h; Ambient temperature;

: 78869-44-0
(η5-C5H4CH3)3Pr

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 2Pr(3+)*4C5H4CH3(1-)*2OCH(CH3)CH2COOC2H5(1-)=[(C5H4CH3)2Pr(OCH(CH3)CH2COOC2H5)]2

Conditions

Conditions	Yield
In toluene N2-atmosphere; equimolar amts., -70°C; elem. anal.;	93%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1237525-17-5
Ethyl (3R)-3-{[2-(trimethylsilyl)ethoxy]methoxy}butanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	93%

: 110-87-2
3,4-dihydro-2H-pyran

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 79016-08-3, 90410-58-5, 104372-23-8, 117857-83-7, 117857-84-8, 132073-06-4, 132073-08-6
ethyl (R)-β-tetrahydropyranyloxybutyrate

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane for 3h; Ambient temperature;	92.5%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: (R)-3-hydroxy-butyric acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 90℃; for 16h; Inert atmosphere;	92%
With hydrazine hydrate In ethanol at 90℃; for 16h;	92%
With hydrazine hydrate In ethanol; water Reflux;	1.95 g

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 110972-51-5
potassium (R)-3-hydroxybutyrate

Conditions

Conditions	Yield
With potassium hydroxide In water at 10℃; for 5h;	88.2%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 100-46-9
benzylamine

: 146679-25-6
(R)-N-benzyl-3-hydroxybutanamide

Conditions

Conditions	Yield
Stage #1: benzylamine With trimethylaluminum In toluene at -5 - 20℃; Stage #2: Ethyl (R)-3-hydroxybutanoate In toluene at -5 - 20℃; for 15.5h;	88%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 120400-77-3
(R)-3-(4-Methoxy-benzyloxy)-butyric acid ethyl ester

Conditions

Conditions	Yield
With (1S)-10-camphorsulfonic acid In dichloromethane for 25h; Ambient temperature;	86%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 6290-03-5
(R)-butane-1,3-diol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 1h; Ambient temperature;	86%
With lithium aluminium tetrahydride In diethyl ether at 0℃; for 0.5h;	85.6%
Stage #1: Ethyl (R)-3-hydroxybutanoate With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 3h; Inert atmosphere; Stage #2: With water In diethyl ether	81%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: 1205121-89-6
(2,6-dichloro-4-methoxyphenyl)-(2,4-dichlorophenyl)methyl trichloroacetimidate

: 1205122-14-0
C20H20Cl4O4

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 20℃; for 1h;	85%

: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

: magnesium (R)-3-hydroxybutyrate

Conditions

Conditions	Yield
Stage #1: Ethyl (R)-3-hydroxybutanoate With sodium hydroxide In water at 10℃; for 5h; Stage #2: With magnesium hydroxide In water for 10h;	85%

Ethyl (R)-3-hydroxybutyrate Specification

This chemical is called Butanoic acid, 3-hydroxy-, ethyl ester, (3R)-, and its CAS registry number is 24915-95-5. With the molecular formula of C₆H₁₂O₃, its product categories are Alcohols, Hydroxy Esters and Derivatives; Chiral Compounds; Chiral Building Blocks; Simple Alcohols (Chiral); Synthetic Organic Chemistry; Chiral Building Blocks. In addition, this chemical should be sealed in the cool and dry place, away from oxides.

Other characteristics of the Butanoic acid, 3-hydroxy-, ethyl ester, (3R)- can be summarised as followings: (1)ACD/LogP: 0.10; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.098; (4)ACD/LogD (pH 7.4): 0.098; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 26.922; (8)ACD/KOC (pH 7.4): 26.922; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 46.53 Å²; (13)Index of Refraction: 1.427; (14)Molar Refractivity: 33.114 cm³; (15)Molar Volume: 128.941 cm³; (16)Polarizability: 13.128×10^-24cm³; (17)Surface Tension: 33.285 dyne/cm; (18)Density: 1.025 g/cm³; (19)Flash Point: 64.444 °C; (20)Enthalpy of Vaporization: 47.888 kJ/mol; (21)Boiling Point: 174.999 °C at 760 mmHg; (22)Vapour Pressure: 0.362 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing to avoid contacting with skin and eyes. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: CCOC(=O)C[C@@H](C)O
2.InChI: InChI=1/C6H12O3/c1-3-9-6(8)4-5(2)7/h5,7H,3-4H2,1-2H3/t5-/m1/s1
3.InChIKey: OMSUIQOIVADKIM-RXMQYKEDBL

Product Name

Ethyl (R)-3-hydroxybutyrate

Synthetic route

Ethyl (R)-3-hydroxybutyrate Specification

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