Flutazolam supplier | CasNO.27060-91-9

Name
Flutazolam
EINECS
CAS No. 27060-91-9
Article Data8
CAS DataBase
Density 1.47g/cm³
Solubility
Melting Point 142-147°
Formula C19H18 Cl F N2 O3
Boiling Point 601.9°Cat760mmHg
Molecular Weight 376.815
Flash Point 317.8°C
Transport Information
Appearance
Safety Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F⁻, Cl⁻, and NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one,10-chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)- (8CI);Coreminal; Flutazolam; MS 4101; Ro 7-6102
PSA 53.01000
LogP 2.35420

Flutazolam Chemical Properties

IUPAC Name: 10-Chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-[1,3]oxazolo[3,2-d][1,4 ]benzodiazepin-6-one
Synonyms of Flutazolam (CAS NO.27060-91-9): 10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one ; Flutazolam ; Flutazolamum ; Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-
InChI: InChI=1/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2 CAS NO:27060-91-9
Molecular Formula: C₁₉H₁₈ClFN₂O₃
Molecular Weight: 376.8092
Molecular Structure :

Index of Refraction: 1.672 Surface
Tension: 67.3 dyne/cm
Density: 1.47 g/cm³
Flash Point: 317.8 °C
Enthalpy of Vaporization: 94.18 kJ/mol
Boiling Point: 601.9 °C at 760 mmHg
Vapour Pressure: 2.44E-15 mmHg at 25 °C

Flutazolam History

It was invented in Japan, and this is the main country in which it has been used medically.

Flutazolam Uses

Flutazolam (CAS NO.27060-91-9) is a drug which is a benzodiazepine derivative.

Flutazolam Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1680mg/kg (1680mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
mouse	LD50	oral	1910mg/kg (1910mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 2335, 1978.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat	LD50	intraperitoneal	4050mg/kg (4050mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat	LD50	oral	> 6gm/kg (6000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.
rat	LD50	subcutaneous	> 6gm/kg (6000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 1997, 1978.

Flutazolam Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When Flutazolam (CAS NO.27060-91-9) is heated to decomposition ,it emits toxic fumes of F⁻, Cl⁻, and NO_x.

Flutazolam Specification

Flutazolam (CAS NO.27060-91-9) has sedative, muscle relaxant, anticonvulsant, and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and though it's around the same potency as diazepam, it produces a more marked sedation and impaired coordination

Product Name

Flutazolam