1,3,5-Triazine
A
formamidine hydrochloride
B
ethyl 4-methylpyrimidine-5-carboxylate
Conditions | Yield |
---|---|
In acetonitrile for 6h; Product distribution; Mechanism; Heating; further N-substituted enaminone hydrochlorides; | A n/a B 7% C 45% |
In acetonitrile for 6h; Heating; | A n/a B 7% C 45% |
1,3,5-Triazine
A
formamidine hydrochloride
B
ethyl 4-methylpyrimidine-5-carboxylate
Conditions | Yield |
---|---|
In acetonitrile for 6h; Heating; | A n/a B 6% C 38% |
1,3,5-Triazine
A
formamidine hydrochloride
B
ethyl 4-methylpyrimidine-5-carboxylate
Conditions | Yield |
---|---|
In acetonitrile for 6h; Heating; | A n/a B 10% C 33% |
1,3,5-Triazine
A
formamidine hydrochloride
B
ethyl 4-methylpyrimidine-5-carboxylate
Conditions | Yield |
---|---|
In acetonitrile for 6h; Heating; | A n/a B 6% C 33% |
Conditions | Yield |
---|---|
In acetonitrile for 6h; Heating; | A n/a B 5% C 31% |
1,3,5-Triazine
A
formamidine hydrochloride
B
ethyl 4-methylpyrimidine-5-carboxylate
Conditions | Yield |
---|---|
In acetonitrile for 6h; Heating; | A n/a B 6% C 30% |
Conditions | Yield |
---|---|
In acetonitrile for 6h; Heating; | A n/a B 28% C 7% |
1,3,5-Triazine
trichloroacetamidine hydrochloride
acetonitrile
A
2-trichloromethyl-[1,3,5]triazine
B
formamidine hydrochloride
ethanol
chloromethylene-formamidine
A
formamidine hydrochloride
B
orthoformic acid triethyl ester
Conditions | Yield |
---|---|
in der Kaelte; |
thiourea
formamidine hydrochloride
Conditions | Yield |
---|---|
With ammonium chloride bei folgendem Kochen mit Raney-Nickel in absol. Aethanol; |
1,3,5-Triazine
hydrogenchloride
ethanol
A
formamidine hydrochloride
B
orthoformic acid triethyl ester
formamidine hydrochloride
Conditions | Yield |
---|---|
With ammonia |
Conditions | Yield |
---|---|
With acetyl chloride In methanol at 5℃; Inert atmosphere; | |
With hydrogenchloride In water | |
With hydrogenchloride In water at 20℃; for 2h; | |
With hydrogenchloride |
Conditions | Yield |
---|---|
Stage #1: triethyl 1,1,2-ethanetricarboxylate; formamidine hydrochloride With sodium methylate In methanol at 20℃; Stage #2: With hydrogenchloride In methanol; water at 0℃; | 99.99% |
formamidine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite at 0 - 20℃; for 2h; | 99.2% |
formamidine hydrochloride
4-carbamoylbenzamidine hydrochloride
2,4-bis<(4-carbamoyl)phenyl>-1,3,5-triazine
Conditions | Yield |
---|---|
at 190℃; for 16h; | 98% |
formamidine hydrochloride
2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate
N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-N'-formamidinothiocarboxamides
Conditions | Yield |
---|---|
With triethylamine In acetonitrile Ambient temperature; | 97% |
formamidine hydrochloride
ethyl 4,4,4-trifluoroacetoacetate
4-hydroxy-6-trifluoromethylpyrimidine
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In ethanol at 70 - 80℃; | 96% |
formamidine hydrochloride
Conditions | Yield |
---|---|
With silver(I) dinitramide In ethanol | 95% |
Conditions | Yield |
---|---|
Stage #1: formamidine hydrochloride With sodium In 1,4-dioxane at 0℃; for 0.5h; Inert atmosphere; Stage #2: C14H16N2O7S In 1,4-dioxane | 95% |
Conditions | Yield |
---|---|
With copper 8-hydroxyquinolinate; sodium hydroxide In water at 100℃; for 0.5h; Microwave irradiation; | 94% |
formamidine hydrochloride
2,3,4-tri-O-acetyl-α-D-arabinopyranosyl isotyhiocyanate
N-(2,3,4-tri-O-acetyl-α-D-arabinopyranosyl)-N'-formamidinothiocarboxamides
Conditions | Yield |
---|---|
With triethylamine In acetonitrile Ambient temperature; | 93% |
formamidine hydrochloride
Conditions | Yield |
---|---|
With sodium methylate In methanol at 20℃; for 24h; | 93% |
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol at 140℃; for 48h; Inert atmosphere; | 93% |
2-iodo-5-nitro-benzoic acid
formamidine hydrochloride
6-nitroquinazolone
Conditions | Yield |
---|---|
With 8-quinolinol; sodium hydroxide; copper dichloride In water at 20℃; for 0.333333h; Sealed tube; Microwave irradiation; | 93% |
formamidine hydrochloride
2-(4-bromophenyl)-malonic acid dimethyl ester
5-(4-bromophenyl)-4,6-dihydroxypyrimidine
Conditions | Yield |
---|---|
at 25℃; for 16h; Temperature; | 92.6% |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; | 91% |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium methylate In methanol at 0℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; | |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; Stage #3: With citric acid In water | |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; Stage #3: With citric acid In water for 0.166667h; |
2-iodoyl-5-methylbenzoic acid
formamidine hydrochloride
6-methyl-3H-quinazolin-4-one
Conditions | Yield |
---|---|
With copper 8-hydroxyquinolinate; sodium hydroxide In water at 100℃; for 0.5h; Microwave irradiation; | 92% |
formamidine hydrochloride
Conditions | Yield |
---|---|
Stage #1: formamidine hydrochloride With base In ethanol for 0.166667h; Stage #2: C14H11ClO4 In ethanol at 20℃; for 4h; | 92% |
formamidine hydrochloride
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50 - 110℃; for 10h; | 91.7% |
N-(5-benzoyl-6-methyl-2-oxo-2H-pyran-3-yl)benzamide
formamidine hydrochloride
(E)-2-(benzoylamino)-3-(4-methyl-6-phenylpyrimidin-5-yl)propenoic acid
Conditions | Yield |
---|---|
Stage #1: N-(5-benzoyl-6-methyl-2-oxo-2H-pyran-3-yl)benzamide; formamidine hydrochloride With sodium carbonate In ethanol at 115℃; for 1.5h; Microwave irradiation; Stage #2: With hydrogenchloride In water pH=2; | 91% |
formamidine hydrochloride
ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate
4-hydroxy-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With ethanol; sodium at 20 - 75℃; Temperature; Inert atmosphere; | 91% |
With sodium ethanolate In ethanol Reflux; Inert atmosphere; | 53% |
With sodium ethanolate In ethanol at 70℃; for 5h; | 42% |
5-bromo-2-iodo-benzoic acid
formamidine hydrochloride
6-bromoquinazolin-4(3H)-one
Conditions | Yield |
---|---|
With 8-quinolinol; sodium hydroxide; copper dichloride In water at 20℃; for 0.333333h; Sealed tube; Microwave irradiation; chemoselective reaction; | 91% |
Conditions | Yield |
---|---|
With sodium methylate In methanol at 25 - 70℃; for 10h; | 91% |
2-bromo-4,5-dimethoxybenzonitrile
formamidine hydrochloride
4-amino-6,7 dimethoxyquinazoline
Conditions | Yield |
---|---|
Stage #1: 2-bromo-4,5-dimethoxybenzonitrile; formamidine hydrochloride With potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane for 0.166667h; Inert atmosphere; Stage #2: With copper(l) iodide In 1,4-dioxane for 2.5h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux; | 90.6% |
formamidine hydrochloride
N-[(5-pyrimidinyl)methyl]-2-pyridinamine
Conditions | Yield |
---|---|
With sodium carbonate In acetonitrile at 60℃; for 35h; Temperature; Reagent/catalyst; Solvent; | 90.5% |
formamidine hydrochloride
N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine
Conditions | Yield |
---|---|
With sodium methylate In methanol; N,N-dimethyl-formamide at 50 - 110℃; for 10h; Temperature; | 90.2% |
N-(5-acetyl-6-methyl-2-oxo-2H-pyran-3-yl)-benzamide
formamidine hydrochloride
(E)-2-(benzoylamino)-3-(4,6-dimethylpyrimidin-5-yl)propenoic acid
Conditions | Yield |
---|---|
Stage #1: N-(5-acetyl-6-methyl-2-oxo-2H-pyran-3-yl)-benzamide; formamidine hydrochloride With sodium carbonate In ethanol at 100℃; for 1h; Microwave irradiation; Stage #2: With hydrogenchloride In water pH=2; | 90% |
methanol
triethyl 1,1,2-ethanetricarboxylate
sodium methylate
formamidine hydrochloride
Conditions | Yield |
---|---|
Stage #1: formamidine hydrochloride With methanol; sodium at 20℃; for 1h; Stage #2: methanol; triethyl 1,1,2-ethanetricarboxylate; sodium methylate at 20℃; Inert atmosphere; Stage #3: With hydrogenchloride In water pH=1 - 2; Cooling with ice; | 90% |
(2-propenyl)propanedioic acid diethyl ester
formamidine hydrochloride
6-hydroxy-5-(2-propen-1-yl)-4(1H)-pyrimidinone
Conditions | Yield |
---|---|
Stage #1: formamidine hydrochloride With sodium methylate In methanol at 20℃; for 1h; Stage #2: (2-propenyl)propanedioic acid diethyl ester In methanol at 20℃; for 36h; | 90% |
With sodium methylate In methanol at 20℃; for 37h; Inert atmosphere; | 90% |
ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate
formamidine hydrochloride
Conditions | Yield |
---|---|
With potassium hydride; acetic acid In methanol at 20℃; for 0.5h; | 90% |
2-iodo-5-methoxybenzoic acid
formamidine hydrochloride
6-Methoxyquinazolin-4-one
Conditions | Yield |
---|---|
With 8-quinolinol; sodium hydroxide; copper dichloride In water at 20℃; for 0.333333h; Sealed tube; Microwave irradiation; | 89% |
4-<(diethylphosphoryl)oxy>-1,1,1,2,2,3-hexafluoro-3-decene
formamidine hydrochloride
5-Fluoro-4-hexyl-6-trifluoromethyl-pyrimidine
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran Ambient temperature; | 88% |
Conditions | Yield |
---|---|
Stage #1: ethyl 2-methyl-4,4,4-trifluoroacetoacetate; formamidine hydrochloride In ethanol at 20℃; for 2h; Stage #2: With sodium ethanolate In ethanol at 80℃; for 4h; | 88% |
The Methanimidamide,hydrochloride (1:1), with the CAS registry number 6313-33-3, is also known as Formamidinium chloride. It belongs to the product categories of Pharmacetical; Imines/Amidines; Nitrogen Compounds; Organic Building Blocks. Its EINECS registry number is 228-639-2. This chemical's molecular formula is CH5ClN2 and molecular weight is 80.52. Its IUPAC name is called methanimidamide chloride. When you are using this chemical, please be cautious about it, you should not breathe its dust. Besides, you must avoid contacting it with your eyes.
Physical properties of Methanimidamide,hydrochloride (1:1): (1)ACD/LogP: -1.17; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.17; (4)ACD/LogD (pH 7.4): -3.16; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 3; (11)Flash Point: 16.8 °C; (12)Enthalpy of Vaporization: 29.01 kJ/mol; (13)Boiling Point: 46.3 °C at 760 mmHg; (14)Vapour Pressure: 337 mmHg at 25°C.
Uses of Methanimidamide,hydrochloride (1:1): it can be used to produce 5-fluoro-4-phenyl-6-trifluoromethyl-pyrimidine at ambient temperature. This reaction will need reagent NaH and solvent tetrahydrofuran. The yield is about 66%.
You can still convert the following datas into molecular structure:
(1)SMILES: Cl.[N@H]=CN
(2)InChI: InChI=1/CH4N2.ClH/c2-1-3;/h1H,(H3,2,3);1H
(3)InChIKey: NMVVJCLUYUWBSZ-UHFFFAOYAG
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