Glycinamide Hydrochloride supplier

Name
Glycinamide hydrochloride
EINECS 216-789-1
CAS No. 1668-10-6
Article Data10
CAS DataBase
Density 1.122 g/cm³
Solubility water: 0.1 g/mL, clear
Melting Point 204 °C (dec.)(lit.)
Formula C₂H₆N₂O^.HCl
Boiling Point 281.3 °C at 760 mmHg
Molecular Weight 110.543
Flash Point 123.9 °C
Transport Information
Appearance Crystalline
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Acetamide,2-amino-, monohydrochloride (9CI);Glycinamide, monohydrochloride (8CI);Aminoacetamide hydrochloride;Glycine amide hydrochloride;H-Gly-NH2·HCl;H-Gly-NH2.HCl;
PSA 69.11000
LogP 0.63300

Synthetic route

: 540-61-4
2-aminoacetonitrile

: 1668-10-6
glycinamide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; 2-hydroxyethanethiol In tetrahydrofuran at -78℃;	86%

: 79-07-2
Chloroacetamide

: 1668-10-6
glycinamide hydrochloride

Conditions

Conditions	Yield
With ammonia In ethanol at 100℃; for 0.5h;	76%

: 141509-41-3
4-methylene-1-oxa-6,9-diazaspiro<4,5>decane-7,10-dione

A: 1668-10-6
glycinamide hydrochloride

B: 114533-59-4
3-hydroxy-4-(2-hydroxyethyl)-2(5H)-furanone

Conditions

Conditions	Yield
With hydrogenchloride at 100℃; for 1.5h; Product distribution; other conditions, other reagents;	A 33% B 56%

: 2-amino-acetimidic acid methyl ester; dihydrochloride

: 1668-10-6
glycinamide hydrochloride

Conditions

Conditions	Yield
bei dreiwoechigem Aufbewahren;

: 5680-79-5
glycine ethyl ester hydrochloride

: 1668-10-6
glycinamide hydrochloride

Conditions

Conditions	Yield
With ammonia In methanol for 72h; Ambient temperature;

: 1668-10-6
glycinamide hydrochloride

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 35010-96-9
Nα-benzyloxycarbonyl-L-prolyl-glycinamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	100%
Stage #1: N-Benzyloxycarbonyl-L-proline With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; Stage #2: glycinamide hydrochloride With triethylamine In tetrahydrofuran at 20℃; Further stages.;	53%
With 4-methyl-morpholine; isobutyl chloroformate 1) DMF, -15 deg C, 15 min, 2) -10 deg C, 14h; Yield given. Multistep reaction;

: 1668-10-6
glycinamide hydrochloride

: 60379-01-3
N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester

: 17187-05-2
Z-L-phenylalanylglycinamide

Conditions

Conditions	Yield
With S166C-SBnCOOH; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 1h; Ambient temperature;	100%
With triethylamine; enzyme mutant SBL-S166C-S-[(4S,5R)-indenooxazolidinonyl] In water; N,N-dimethyl-formamide at 20℃; for 1h; pH=5.8;	100%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Glc(Ac)2 subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 1h; pH=5.8; Enzymatic reaction; MES buffer;	95%
With subtilisin BPN'; triethylamine In water; N,N-dimethyl-formamide Ambient temperature;	80%

: 5672-83-3
Z-L-GluOMe

: 1668-10-6
glycinamide hydrochloride

: 126530-12-9
Z-L-Glu-Gly-NH2

Conditions

Conditions	Yield
With S166C-SCH2CH2NH3+; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;	100%
With triethylamine; enzyme mutant SBL-S166C-S-CH2C(CH2NH3)3 In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8;	71%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Gal subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8; Enzymatic reaction; MES buffer;	67%

: 1668-10-6
glycinamide hydrochloride

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 115057-37-9
Fmoc-Gly-NH2

Conditions

Conditions	Yield
With sodium carbonate In acetone at 20℃; for 1h;	100%
With sodium hydrogencarbonate In acetone at 20℃; for 2h; pH=7;	80%
With sodium carbonate In water; acetone at 0 - 20℃; for 1.5h;	72%

: 912773-22-9
6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 1668-10-6
glycinamide hydrochloride

: 1065082-89-4
N-(2-amino-2-oxoethyl)-6-bromopyrazolo[1,5-a]pyrimidine-3-carboxamide

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;	100%

: 1435472-77-7
sodium 1-(2,5-dimethoxyphenyl)-3-ethoxy-3-oxoprop-1-en-1-olate

: 1668-10-6
glycinamide hydrochloride

: 1435472-78-8
ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

Conditions

Conditions	Yield
Stage #1: glycinamide hydrochloride With sodium methylate at 65℃; for 1h; Stage #2: sodium 1-(2,5-dimethoxyphenyl)-3-ethoxy-3-oxoprop-1-en-1-olate With acetic acid at 10℃; for 16.5h;	100%

: 1668-10-6
glycinamide hydrochloride

: 126028-14-6
2,2,2-trifluoroethyl ((benzyloxy)carbonyl)-L-phenylalaninate

A: 1161-13-3
N-Cbz-L-Phe

B: 17187-05-2
Z-L-phenylalanylglycinamide

Conditions

Conditions	Yield
With Tris buffer; TEA; Celite; α-chymotrypsin In acetonitrile at 30℃; for 1h;	A 0.6% B 99%

...Expand

: 1668-10-6
glycinamide hydrochloride

: 69861-90-1
Nα-benzyloxycarbonyl-L-lysine thiobenzyl ester

: Z-L-Lys-Gly-NH2

Conditions

Conditions	Yield
With S166C-SBnCOOH; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;	99%

: 1668-10-6
glycinamide hydrochloride

: 88718-12-1
Z-L-Ala benzyl ester

: 4976-59-4
CBZ-L-alanylglycinamide

Conditions

Conditions	Yield
With triethylamine; enzyme mutant SBL-S166C-S-(CH2)2-NMe3(1+) In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8;	99%
With S166C-SBn; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;	95%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Gal(Ac)3 subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8; Enzymatic reaction; MES buffer;	92%

: 1668-10-6
glycinamide hydrochloride

: 35899-43-5
Boc-His(Tos)-OH

: N-Boc-Nim-tosylhistidylglycinamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran for 24h; slowly from 0 deg C to room temp.;	98%

: 1668-10-6
glycinamide hydrochloride

: 192214-00-9
(S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid

: 1352661-21-2
C15H19N3O4

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃; for 24h; Inert atmosphere;	98%

: 1668-10-6
glycinamide hydrochloride

: 113699-68-6
<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>sulfonyl>chloride

: 2-<<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>sulfonyl>amino>acetamide

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane for 1h; Ambient temperature;	97.8%

: 1207971-26-3
3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoic acid

: 1668-10-6
glycinamide hydrochloride

: 1207965-95-4
N-(2-amino-2-oxoethyl)-3-{4-fluoro-2-[3-(trifluoromethyl)-benzyl]-1-benzothiophen-7-yl}benzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 0 - 20℃; for 1h; Inert atmosphere;	97%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 5h;	60%

: 1668-10-6
glycinamide hydrochloride

: 814-68-6
acryloyl chloride

: 2479-62-1
N-acryloyl glycinamide

Conditions

Conditions	Yield
With potassium carbonate In water; acetonitrile at 5 - 30℃; for 7h; Reagent/catalyst; Solvent;	97%
Stage #1: glycinamide hydrochloride With potassium carbonate In water Stage #2: acryloyl chloride In diethyl ether; water at 5 - 20℃;	72%
With potassium carbonate In dichloromethane at 5 - 20℃; pH=7 - 8;	68%

: 585-76-2
m-bromobenzoic acid

: 1668-10-6
glycinamide hydrochloride

: N-(2-amino-2-oxoethyl)-3-bromobenzamide

Conditions

Conditions	Yield
Stage #1: glycinamide hydrochloride With triethylamine In dichloromethane for 0.25h; Stage #2: m-bromobenzoic acid With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; Cooling with ice;	97%

: 1668-10-6
glycinamide hydrochloride

: 71449-08-6
(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid

: 146349-33-9
D-(benzyloxycarbonyl)-β-tert-butylaspartylglycinamide

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide a) 4 deg C, 3 h, b) RT, 4 h;	96.6%

: 1668-10-6
glycinamide hydrochloride

: 131949-12-7
(1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl

: (1H-indol-3-ylcarbonyl)-Asp(Gly-NH2)-Phe-NMeBzl

Conditions

Conditions	Yield
With benzotriazol-1-ol In N,N-dimethyl-formamide 1.) 0 deg C, 1 h, 2.) RT, 3 h;	96%

: 5435-64-3
3,5,5-trimethyl hexanal

: 1668-10-6
glycinamide hydrochloride

: 1378479-17-4
(+/-)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one

Conditions

Conditions	Yield
With triethylamine In methanol for 18h; Inert atmosphere; Reflux;	96%

: 2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxylic acid

: 1668-10-6
glycinamide hydrochloride

: N-(2-amino-2-oxoethyl)-2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxamide

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	96%

: 1118-66-7
4-Aminopent-3-en-2-one

: 1668-10-6
glycinamide hydrochloride

: 131474-82-3
N-(1-methyl-3-oxo-1-butenyl)glycinamide

Conditions

Conditions	Yield
In methanol for 3h; Heating;	95%

: 716-76-7
3-phenylbenzoic acid

: 1668-10-6
glycinamide hydrochloride

: N-(2-amino-2-oxoethyl)-[1,1‘-biphenyl]-3-carboxamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane	95%

: 1668-10-6
glycinamide hydrochloride

: 56-40-6
glycine

Conditions

Conditions	Yield
Stage #1: glycinamide hydrochloride With sodium hydroxide In water Stage #2: In water at 130℃; for 1h; Reagent/catalyst;	94.5%

: 1065083-05-7
6-boronopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: 1668-10-6
glycinamide hydrochloride

: 1065083-09-1
(3-{[(2-amino-2-oxoethyl)amino]carbonyl}pyrazolo[1,5-a]pyrimidin-6-yl)boronic acid

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;	94%

: 1207970-84-0
ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate

: 1668-10-6
glycinamide hydrochloride

: 1207965-12-5
N-(2-amino-2-oxoethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

Conditions

Conditions	Yield
Stage #1: ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate With water; sodium hydroxide In tetrahydrofuran; ethanol at 60℃; for 0.5h; Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water Stage #3: glycinamide hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 2h;	94%

: 1178896-02-0, 1251932-92-9
2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

: 1668-10-6
glycinamide hydrochloride

: 1251933-09-1
2-(3-(2-amino-2-oxoethylamino)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 100℃; for 3h; Microwave irradiation; Sealed vial;	94%

: 110-41-8
2-methylundecanal

: 1668-10-6
glycinamide hydrochloride

: 1378479-35-6
(+/-)-2-(undecan-2-yl)imidazolidin-4-one

Conditions

Conditions	Yield
With triethylamine In methanol for 18h; Inert atmosphere; Reflux;	94%

: 1668-10-6
glycinamide hydrochloride

: Fmoc-Asp(tBu)-Glu(tBu)-Val-Asp(tBu)-OH

: C47H66N6O13

Conditions

Conditions	Yield
Stage #1: Fmoc-Asp(tBu)-Glu(tBu)-Val-Asp(tBu)-OH With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.75h; Stage #2: glycinamide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;	94%

: 1668-10-6
glycinamide hydrochloride

: 114042-88-5
5-amino-4-hexen-3-one

: 131474-85-6
N-(1-methyl-3-oxo-1-pentenyl)glycinamide

Conditions

Conditions	Yield
In methanol for 3h; Heating;	93%

: 104029-20-1
ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate

: 1668-10-6
glycinamide hydrochloride

: 1435472-76-6
(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

Conditions

Conditions	Yield
Stage #1: glycinamide hydrochloride With sodium methylate In methanol at 65℃; for 1h; Stage #2: ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate With acetic acid at 50℃; for 16h;	93%
Stage #1: glycinamide hydrochloride With sodium methylate In methanol at 65℃; for 1h; Stage #2: ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate With acetic acid In methanol at 50℃; for 16h; Reflux;	339.4 g

: 1668-10-6
glycinamide hydrochloride

: 131474-81-2
(Z)-3-amino-1-(p-tolyl)but-2-en-1-one

: 131474-97-0
N-(1-methyl-3-oxo-3-p-tolyl-1-propenyl)glycinamide

Conditions

Conditions	Yield
In methanol for 6h; Heating;	92%

Glycinamide Hydrochloride Chemical Properties

IUPAC Name: 2-Aminoacetamide hydrochloride
Molecular Formula: C₂H₇ClN₂O
Molecular Weight:110.542780 g/mol
Appearance: White to off-white solid
Water solubility: 0.1 g/mL, clear
BRN: 3554199
Density: 1.122g/cm³
Melting Point: 204 oC
Flash Point: 123.9°C
storage temp.: Store at RT.
Index of Refraction: 1.469
Surface Tension: 49.1 dyne/cm
Enthalpy of Vaporization: 52.01 kJ/mol
Boiling Point: 281.3 °C at 760 mmHg
Vapour Pressure: 0.00359 mmHg at 25 °C
Synonyms of Glycinamide Hydrochloride(1668-10-6):
h-Gly-nh2 hcl;glycinamide hcl ; Glycinamide hydrochloride ; Glycine-nh2 hcl;glycine amide hydrochloride ; Gly-nh2 hydrochloride ; 2-Aminoacetamide hydrochloride ; Glycinamide monohydrochloride
Categories of Glycinamide Hydrochloride(1668-10-6):
Amino Acid Derivatives;(intermediate of oxiracetam);Amino Acids;Glycine [Gly, G];Amino Acids and Derivatives;Amino hydrochloride;Amides;Carbonyl Compounds;Organic Building Blocks;A - HOrganic Building Blocks;Amino Acids;Modified Amino Acids

Glycinamide Hydrochloride Uses

Glycinamide Hydrochloride(1668-10-6) is used as a pharmaceutical intermediate,also used in the organic synthesis.

Glycinamide Hydrochloride Safety Profile

Safety Information of Glycinamide Hydrochloride(1668-10-6):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:22-24/25-37/39-26
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
37/39:Wear suitable gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:3
F:3-10
HS Code:29241900

Glycinamide Hydrochloride Specification

First Aid Measures of Glycinamide Hydrochloride(1668-10-6):
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Storage of Glycinamide Hydrochloride(1668-10-6):
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

Product Name

Glycinamide hydrochloride

Synthetic route

Glycinamide Hydrochloride Chemical Properties

Glycinamide Hydrochloride Uses

Glycinamide Hydrochloride Safety Profile

Glycinamide Hydrochloride Specification

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