Hydrocortisone acetate supplier

Name
Hydrocortisone acetate
EINECS 200-004-4
CAS No. 50-03-3
Article Data22
CAS DataBase
Density 1.26 g/cm/³
Solubility Insoluble in water.
Melting Point 223 °C (dec.)(lit.)
Formula C₂₃H₃₂O₆
Boiling Point 576.6 °C at 760 mmHg
Molecular Weight 404.503
Flash Point 196.2 °C
Transport Information
Appearance white powder
Safety 36/37
Risk Codes 63
Molecular Structure
Hazard Symbols Xn
Synonyms Cortacream;Cortaid;Cortef acetate;Cortell;Corticaine;Cortifoam;Cortril acetate;Cortril acetate AS;Efcolin;HA;Hc 45;Hycortole acetate;Hydrocort acetate;Hydrocortisat;Hydrocortisone 21-acetate;Cortisolacetate (6CI);Cortisol, 21-acetate (7CI,8CI);11b,17a,21-Trihydroxypregn-4-ene-3,20-dione21-acetate;17-Hydroxycorticosterone 21-acetate;17a-Hydroxycorticosterone acetate;21-Acetoxy-11b,17-dihydroxypregn-4-en-3,20-dione;21-Acetoxy-11b,17-dihydroxypregn-4-ene-3,20-dione;21-Acetoxy-11b,17a-dihydroxypregn-4-ene-3,20-dione;Abbocort;Anusol HC;Bambicort;Berlison F;Biocortar;CaldeCort;Chemysone;Colifoam;Colofoam;Cordes;
PSA 100.90000
LogP 2.35240

Synthetic route

: 50-23-7
HYDROCORTISONE

: 108-24-7
acetic anhydride

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With pyridine at 20℃;	100%
With pyridine at 0 - 25℃; for 24h;	99%
With pyridine at 0 - 20℃;	91%

: 50-23-7
HYDROCORTISONE

: 79-20-9
acetic acid methyl ester

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With Candida antarctica lipase B In ethyl acetate at 55℃; regioselective reaction;	92%

: 21940-45-4
Δ6-hydrocortisone-21-acetate

A: 50-03-3
hydrocortisone acetate

B: 11β,17α-dihydroxy-21-acetoxy-5α/5β-pregnan-3-one

Conditions

Conditions	Yield
With hydrogen; Pd/SrCO3 In ethyl acetate for 0.333333h; atmospheric pressure;	A 42% B 19%

: 463-51-4
Ketene

: 50-23-7
HYDROCORTISONE

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With acetone

: 31085-34-4
21-acetoxy-11β-hydroxy-pregna-4,17(20)c-dien-3-one

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With osmium(VIII) oxide; [bis(acetoxy)iodo]benzene
With osmium(VIII) oxide; triethylamine N-oxide; dihydrogen peroxide

: 114160-28-0
4β-chloro-17-hydroxy-5β-pregnane-3,11,20-trione

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
ueber mehrere Stufen;

: 119180-68-6
21-acetoxy-11β-hydroxy-pregna-4,17(20)t-dien-3-one

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With osmium(VIII) oxide; [bis(acetoxy)iodo]benzene
With osmium(VIII) oxide; triethylamine N-oxide; dihydrogen peroxide

: 64313-94-6
RU 18760

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With bromine dann mit Semicarbazid und anschliessend mit Brenztraubensaeure;

: 108-05-4
vinyl acetate

: 50-23-7
HYDROCORTISONE

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With Candida antarctica lipase B In tetrahydrofuran at 45℃; for 4h; Yield given;

: 102213-14-9
22-acetoxy-11β-hydroxy-3-oxo-23,24-dinor-5β-chol-17(20)ξ-ene-21-nitrile

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: OsO4 2: bromine / dann mit Semicarbazid und anschliessend mit Brenztraubensaeure View Scheme

: 603-96-3
3α,11α,17-trihydroxy-5β-pregnan-20-one

A: 50-03-3
hydrocortisone acetate

B CrO3: CrO3

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 2: CrO3; pyridine 3: ueber mehrere Stufen View Scheme

: 641-78-1
3α,17-dihydroxy-5β-pregnane-11,20-dione

A: 50-03-3
hydrocortisone acetate

B CrO3: CrO3

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tert-butyl hypochlorite; water; tert-butyl alcohol; HCl 2: ueber mehrere Stufen View Scheme

: 4β-chloro-11α,17-dihydroxy-5β-pregnane-3,20-dione

A: 50-03-3
hydrocortisone acetate

B CrO3: CrO3

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CrO3; pyridine 2: ueber mehrere Stufen View Scheme

: 116105-53-4
20,20-ethanediyldioxy-3α,17-dihydroxy-5β-pregnan-11-one

A: 50-03-3
hydrocortisone acetate

B CrO3: CrO3

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: LiAlH4 / folgenden mit wss.HCl 3: CrO3; pyridine 4: ueber mehrere Stufen View Scheme

: 50733-54-5
21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione

: 10025-73-7
chromium(III) chloride

: 7440-66-6
zinc

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With acetic acid In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone

...Expand

: chromium chloride hexahydrate

: 50733-54-5
21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With zinc In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone

: 29042-01-1
21-acetoxy-9-chloro-11β,17-dihydroxy-pregn-4-ene-3,20-dione

: 50-03-3
hydrocortisone acetate

: 9α-bromohydrocortisone acetate

: 68-11-1
mercaptoacetic acid

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
In N,N-dimethyl-formamide
In N,N-dimethyl-formamide

: C25H38N6O6

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
Stage #1: C25H38N6O6 With hydrogenchloride In chloroform; water at 25 - 30℃; for 0.5h; Stage #2: With sodium nitrite In chloroform; water at 5 - 10℃; for 2h;	18.1 g

: C23H36N6O5

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium acetate; acetic acid / acetone / 5 h / Reflux 2.1: hydrogenchloride / water; chloroform / 0.5 h / 25 - 30 °C 2.2: 2 h / 5 - 10 °C View Scheme

: C25H38N6O6

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
Stage #1: C25H38N6O6 With hydrogenchloride In chloroform; water at 25 - 30℃; for 0.5h; Stage #2: With sodium nitrite In chloroform; water at 5 - 10℃; for 2h;

: 7753-60-8
anecortave

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With rhodium chloride; water In methanol at 20 - 65℃; for 4h; Autoclave;	85 g
Multi-step reaction with 2 steps 1: water; tetrafluoroboric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / acetone / -5 °C 2: mercaptoacetic acid; zinc; chromium(III) chloride hexahydrate / dimethyl sulfoxide; 2-methyltetrahydrofuran / -5 °C / Inert atmosphere View Scheme

: 1035-69-4
androst-4,9(11)-dien-3,17-dione

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium tert-butylate / tetrahydrofuran / 8 h / 20 - 40 °C 2: dihydrogen peroxide / dichloromethane / 1.5 h / 20 - 40 °C 3: water; rhodium chloride / methanol / 4 h / 20 - 65 °C / Autoclave View Scheme

: 50733-54-5
21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With hydrogenchloride; chromium chloride; mercaptoacetic acid In tetrahydrofuran; water; N,N-dimethyl-formamide at 10 - 60℃; for 2.5h; Inert atmosphere;
With chromium(III) chloride hexahydrate; mercaptoacetic acid; zinc In 2-methyltetrahydrofuran; dimethyl sulfoxide at -5℃; Solvent; Temperature; Inert atmosphere;	45.5 g

: 65208-85-7
21-chloro-11,17-dihydroxy-pregn-4-ene-3,20-dione

: 127-08-2
potassium acetate

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 80℃;	0.94 g

: 110529-68-5
9-bromo-21-chloro-11β,17-dihydroxy-pregn-4-ene-3,20-dione

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride; chromium chloride; zinc / N,N-dimethyl-formamide; water / 0 - 15 °C / Inert atmosphere 2: N,N-dimethyl-formamide / 80 °C View Scheme

: 75868-48-3
21-chloro-17-hydroxy-pregna-4,9(11)-diene-3,20-dione

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: perchloric acid; N-Bromosuccinimide / acetone / 5 - 20 °C 2: hydrogenchloride; chromium chloride; zinc / N,N-dimethyl-formamide; water / 0 - 15 °C / Inert atmosphere 3: N,N-dimethyl-formamide / 80 °C View Scheme

: 50-04-4
Cortisone acetate

: 50-03-3
hydrocortisone acetate

Conditions

Conditions	Yield
With 9-bora-bicyclo[3.3.1]nonane In tetrahydrofuran at 20℃; for 6h; Time;	14.6 g

: 50-03-3
hydrocortisone acetate

: 7753-60-8
anecortave

Conditions

Conditions	Yield
With pyridine; methanesulfonyl chloride In N,N-dimethyl-formamide at 50 - 82℃; for 2h;	95.85%
With N,N'-Thionyldiimidazole In tetrahydrofuran for 0.5h; Ambient temperature;	40%
With pyridine; methanesulfonyl chloride In N,N-dimethyl-formamide

: 50-03-3
hydrocortisone acetate

: 50-23-7
HYDROCORTISONE

Conditions

Conditions	Yield
With potassium carbonate In methanol for 1h;	95%
With sodium methylate In methanol at 20℃; for 0.5h;	94.82%
With water; sodium hydroxide In tetrahydrofuran at 20℃; for 3h;	91.3%

: 50-03-3
hydrocortisone acetate

: 2-((4aS,4bR,10aR,10bS,11S,12aS)-11-hydroxy-10a,12a-dimethyl-8-oxo-4a,4b,5,6,8,9,10,10a,10b,11,12,12a-dodecahydro-4H-naphtho[2,1-f]chromen-2-yl)-2-oxoethyl acetate

Conditions

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol; 1,1'-(phenyl-λ3-iodanediyl)bis(2-methoxypyridin-1-ium)trifluoromethanesulfonate In 1,2-dichloro-ethane at 60℃; Molecular sieve; Inert atmosphere;	82%

Hydrocortisone acetate Specification

1. Introduction of Hydrocortisone acetate
Hydrocortisone acetate is one kind of white powder. The IUPAC Name of this chemical is [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate. Besides, Hydrocortisone acetate stability is stable, but may be light or moisture sensitive. It is incompatible with strong oxidizing agents. Hydrocortisone acetate belongs to Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Veterinaries;Steroid and Hormone.

The Classification Code of this chemical is Anti-Inflammatory Agents; Drug / Therapeutic Agent; Glucocorticoid; Mutation data; Reproductive Effect.

2. Properties of Hydrocortisone acetate
Physical properties about Hydrocortisone acetate are:
(1)Nominal Mass: 404 Da; (2)Average Mass: 404.4966 Da; (3)Monoisotopic Mass: 404.219889 Da; (4)Index of Refraction: 1.572; (5)Molar Refractivity: 105.15 cm³; (6)Molar Volume: 319.2 cm³; (7)Surface Tension: 54.6 dyne/cm; (8)Density: 1.26 g/cm³; (9)Flash Point: 196.2 °C; (10)Enthalpy of Vaporization: 99.14 kJ/mol; (11)Boiling Point: 576.6 °C at 760 mmHg; (12)Vapour Pressure: 1.08E-15 mmHg at 25°C; (13)Storage temp: 0-6°C; (14)Decomposition: 223°C.

3. Structure Descriptors of Hydrocortisone acetate
(1)InChI: InChI=1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1
(2)InChIKey: InChIKey=ALEXXDVDDISNDU-JZYPGELDSA-N
(3)Smiles: C1[C@@]2([C@H]([C@H]3[C@H]([C@@]4(C(=CC(=O)CC4)CC3)C)[C@H]1O)CC[C@@]2(C(COC(C)=O)=O)O)C

4. Toxicity of Hydrocortisone acetate

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	2300mg/kg (2300mg/kg)	Compilation of LD50 Values of New Drugs.
mouse	LD50	subcutaneous	45050ug/kg (45.05mg/kg)	National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat	LDLo	subcutaneous	250mg/kg (250mg/kg)	Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2102, 1977.

RTECS : GM8960000

5. Safety information of Hydrocortisone acetate
Hazard Codes: Harmful Xn
Risk Statements: 63
R63: Possible risk of harm to the unborn child
Safety Statements: 36/37
S36/37: Wear suitable protective clothing and gloves
WGK Germany: 3

6. Uses of Hydrocortisone acetate
Hydrocortisone acetate can be used for biochemical research. As a sugar cortical hormone drug, it can anti-inflammatory, anti-allergic, antitoxin, resistance to shock action.

7. Production of Hydrocortisone acetate
Hydrocortisone and Acetic anhydride esterification under the condition of Azabenzene can be used to manufacture Hydrocortisone acetate.

Product Name

Hydrocortisone acetate

Synthetic route

Hydrocortisone acetate Specification

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