Product Name

  • Name

    dichlorodihydroxybis(isopropylamine)platinum

  • EINECS
  • CAS No. 62928-11-4
  • Article Data2
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point
  • Formula C6H20 Cl2 N2 O2 Pt
  • Boiling Point 30.9°C at 760 mmHg
  • Molecular Weight 418.223
  • Flash Point
  • Transport Information
  • Appearance
  • Safety Poison by subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and Cl−. See also PLATINUM COMPOUNDS.
  • Risk Codes
  • Molecular Structure Molecular Structure of 62928-11-4 (dichlorodihydroxybis(isopropylamine)platinum)
  • Hazard Symbols
  • Synonyms 2-Propanamine,platinum complex; CHIP; Iproplatin; JM 9; NSC 256927; cis,trans,cis-Dichlorodihydroxobis(isopropylamine)platinum;cis-Dichlorobis(isopropylamine)-trans-dihydroxyplatinum(IV)
  • PSA 92.50000
  • LogP 3.13050

Iproplatin Chemical Properties

Product Name: Iproplatin (CAS NO.62928-11-4)


Molecular Formula:  C6H20Cl2N2O2Pt
Molecular Weight: 418.2192g/mol
Mol File: 62928-11-4.mol
Einecs: 263-762-5
Boiling point: 30.9 °C at 760 mmHg
Enthalpy of Vaporization: 27.83 kJ/mol
Vapour Pressure: 608 mmHg at 25°C
H-Bond Donor: 4
H-Bond Acceptor: 4
Structure Descriptors of Iproplatin (CAS NO.62928-11-4):
  IUPAC Name: dichloroplatinum(2+); propan-2-ylazanide; dihydrate
  Canonical SMILES: CC(C)[NH-].CC(C)[NH-].O.O.Cl[Pt+2]Cl
  InChI: InChI=1S/2C3H8N.2ClH.2H2O.Pt/c2*1-3(2)4;;;;;/h2*3-4H,1-2H3;2*1H;2*1H2;/q2*-1;;;;;+4/p-2 
  InChIKey: BVIQRWGFXPAYEV-UHFFFAOYSA-L

Iproplatin Toxicity Data With Reference

1.    

mmo-esc 10 µmol/L

     MUREAV    Mutation Research. 173 (1986),13.
2.    

mnt-ham:lng 8250 nmol/L

     NEOLA4    Neoplasma. 31 (1984),655.
3.    

ipr-rat LD50:60 mg/kg

     BJCAAI    British Journal of Cancer. 42 (1980),668.
4.    

scu-rat LD50:92 mg/kg

     BJCAAI    British Journal of Cancer. 42 (1980),668.
5.    

ivn-rat LD50:30 mg/kg

     EJCODS    European Journal of Cancer and Clinical Oncology. 20 (1984),1087.
6.    

ipr-mus LD50:60 mg/kg

     EJCODS    European Journal of Cancer and Clinical Oncology. 20 (1984),1087.
7.    

ivn-mus LD50:45 mg/kg

     EJCODS    European Journal of Cancer and Clinical Oncology. 20 (1984),1087.

Iproplatin Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and Cl−. See also PLATINUM COMPOUNDS.

Iproplatin Specification

 Iproplatin ,its CAS NO. is 62928-11-4,the synonyms is CCRIS 3650 ; CHIP ; Diisopropylammine-trans-dihydroxymalonatoplatinum(IV) ; EINECS 263-762-5 ; Iproplatinum ; JM-28 ; JM-9 ; NSC 256927 ; ab-Dichloro-ce-dihydroxy-df-bis(isopropylamine)platinum ; cis-Dichloro-trans-dihydroxybis(isopropylamine)platinum(iv) ; cis-Dichloro-trans-dihydroxybisisopropylamine platinum (IV) ; Dichlorodihydroxybis(isopropylamine)platinum ; Platinum(IV), bis(isopropylammine)-cis-dichloro-trans-dihydroxy- ; Platinum, dichlorodihydroxybis(2-propanamine)-, (OC-6-33) .

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