Product Name

  • Name

    L-5-Hydroxytryptophan

  • EINECS 224-411-1
  • CAS No. 4350-09-8
  • Article Data16
  • CAS DataBase
  • Density 1.484 g/cm3
  • Solubility slightly soluble in water
  • Melting Point 270 °C (dec.)(lit.)
  • Formula C11H12N2O3
  • Boiling Point 520.6 °C at 760 mmHg
  • Molecular Weight 220.228
  • Flash Point 268.7 °C
  • Transport Information UN 2811 6.1/PG 3
  • Appearance white to pale grey powder
  • Safety 36-26
  • Risk Codes 22-36/37/38-65-20/21/22-20/21
  • Molecular Structure Molecular Structure of 4350-09-8 (L-5-Hydroxytryptophan)
  • Hazard Symbols HarmfulXn, IrritantXi
  • Synonyms Tryptophan,5-hydroxy-, L- (8CI);(S)-5-Hydroxytryptophan;5-Hydroxy-L-tryptophan;5-Hydroxyl-L-tryptophan;Cincofarm;L-5-HTP;Levothym;Levotinine;Oxitriptan;Oxyfan;Pretonine;Quietim;Serotonyl;Telesol;Tript-Oh;
  • PSA 99.34000
  • LogP 1.52820

Synthetic route

indol-5-ol
1953-54-4

indol-5-ol

L-serin
56-45-1

L-serin

L-5-HTP
4350-09-8

L-5-HTP

Conditions
ConditionsYield
Stage #1: indol-5-ol; L-serin With pyridoxal 5'-phosphate; thermotoga maritima with tryptophan synthase β-subunit from pyrococcus furiosus M145T N167D mutant In aq. phosphate buffer; water; dimethyl sulfoxide at 75℃; for 2h; pH=8; Sealed tube; Enzymatic reaction;
Stage #2: With hydrogenchloride In water		93%
With transformed Escherichia coli cells at 37℃; for 24h;70 % Chromat.
With tryptophan synthase; pyridoxal 5'-phosphate at 37℃; for 24h; pH=7.8; Enzymatic reaction;
DL-5-hydroxytryptophane amide
90830-06-1

DL-5-hydroxytryptophane amide

L-5-HTP
4350-09-8

L-5-HTP

Conditions
ConditionsYield
43%
43%
L-Tryptophan
73-22-3

L-Tryptophan

A

7-Hydroxy-L-tryptophan
25198-02-1

7-Hydroxy-L-tryptophan

B

4-Hydroxy-L-tryptophan
25242-90-4

4-Hydroxy-L-tryptophan

C

(S)-6-hydroxytryptophan
13567-14-1

(S)-6-hydroxytryptophan

D

L-5-HTP
4350-09-8

L-5-HTP

Conditions
ConditionsYield
With dihydrogen peroxide; edetate disodium; iron(II) sulfate; ascorbic acid In water at 22℃; for 0.0416667h;A n/a
B 10%
C n/a
D 12%
...Expand
L-N-benzyloxycarbonyl-5-benzyloxytryptophan
3520-59-0

L-N-benzyloxycarbonyl-5-benzyloxytryptophan

L-5-HTP
4350-09-8

L-5-HTP

Conditions
ConditionsYield
With ethanol; palladium Hydrogenation;
5-benzyloxy-Nα-benzyloxycarbonyl-DL-tryptophan
3017-27-4

5-benzyloxy-Nα-benzyloxycarbonyl-DL-tryptophan

L-5-HTP
4350-09-8

L-5-HTP

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: quinine
2: palladium; ethanol / Hydrogenation
View Scheme
L-Tryptophan
73-22-3

L-Tryptophan

A

tryptamine
61-54-1

tryptamine

B

L-kynurenine
2922-83-0

L-kynurenine

C

hydroxyhexahydropyrrolo[2,3-b]indole-2-carboxylic acid

hydroxyhexahydropyrrolo[2,3-b]indole-2-carboxylic acid

D

(S )-2-Amino-4-(2-formamidophenyl)-4-oxobutanoic acid

(S )-2-Amino-4-(2-formamidophenyl)-4-oxobutanoic acid

E

hydroxyoxoindolylalanine

hydroxyoxoindolylalanine

F

2-amino-3-(2-oxoindolin-3-yl)propanoic acid
236094-74-9

2-amino-3-(2-oxoindolin-3-yl)propanoic acid

G

L-5-HTP
4350-09-8

L-5-HTP

Conditions
ConditionsYield
With dihydrogen peroxide at 37℃; for 6h; pH=4.6; Darkness; aq. borate buffer;
...Expand
L-Tryptophan
73-22-3

L-Tryptophan

L-5-HTP
4350-09-8

L-5-HTP

Conditions
ConditionsYield
With tryptophan hydroxylase Enzymatic reaction;
With ferrous ammonium sulphate; 6-methyl-5,6,7,8-tetrahydrobopterin; tryptophan hydroxylase; oxygen In aq. buffer at 20℃; for 0.333333h; pH=7.7; Kinetics; Mechanism; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Enzymatic reaction; chemoselective reaction;
methanol
67-56-1

methanol

L-5-HTP
4350-09-8

L-5-HTP

5-hydroxy-DL-tryptophan methyl ester hydrochloride

5-hydroxy-DL-tryptophan methyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride at -5 - 20℃; for 16h;98%
With thionyl chloride at 0 - 20℃; Inert atmosphere;74%
L-5-HTP
4350-09-8

L-5-HTP

3-(2-aminoethyl)-1H-indol-5-ol
50-67-9

3-(2-aminoethyl)-1H-indol-5-ol

Conditions
ConditionsYield
With pyridoxal 5'-phosphate; aromatic L-amino acid decarboxylase In various solvent(s) at 30℃; for 48h;97%
With NH4OH-NH4Cl buffer; pyridoxal 5'-phosphate at 30℃; for 0.5h; relative rate of CO2 evolution by aromatic L-amino acid decarboxylase from Micrococcus percitreus;
With isopropyl β-D-thiogalactoside; L-tryptophan decarboxylase in recombinant Escherichia coli at 28℃;
9-methoxy-9-BBN
38050-71-4

9-methoxy-9-BBN

L-5-HTP
4350-09-8

L-5-HTP

C19H25BN2O3

C19H25BN2O3

Conditions
ConditionsYield
With pyridine97%
methanol
67-56-1

methanol

L-5-HTP
4350-09-8

L-5-HTP

2-amino-3-(5-hydroxy-1H-indol-3-yl)propionic acid methyl ester
79812-02-5

2-amino-3-(5-hydroxy-1H-indol-3-yl)propionic acid methyl ester

Conditions
ConditionsYield
With thionyl chloride at 0 - 40℃; for 10h;95%
With thionyl chloride at -5 - 35℃; for 5h;92.9%
With hydrogenchloride at 0 - 20℃; for 18h; Fischer esterification;
copper(ll) bromide
7789-45-9

copper(ll) bromide

L-5-HTP
4350-09-8

L-5-HTP

[copper(II)(L-5-hydroxytryptophan)2(bromide)2] monohydrate

[copper(II)(L-5-hydroxytryptophan)2(bromide)2] monohydrate

Conditions
ConditionsYield
In methanol for 3h; Reflux;89%
3,4-dichlorophenylisocyanate
102-36-3

3,4-dichlorophenylisocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(3,4-dichlorophenyl)ureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(3,4-dichlorophenyl)ureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 2.5h;89%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-5-HTP
4350-09-8

L-5-HTP

(S)-2-tert-butoxycarbonylamino-3-(5-tert-butoxycarbonyloxy-1H-indol-3-yl)propionic acid
390816-59-8

(S)-2-tert-butoxycarbonylamino-3-(5-tert-butoxycarbonyloxy-1H-indol-3-yl)propionic acid

Conditions
ConditionsYield
With potassium hydroxide In isopropyl alcohol for 5h; pH=11.5 - 12.0;87%
nickel(II) bromide trihydrate

nickel(II) bromide trihydrate

L-5-HTP
4350-09-8

L-5-HTP

[nickel(II)(L-5-hydroxytryptophan)2(methanol)2(bromide)2]

[nickel(II)(L-5-hydroxytryptophan)2(methanol)2(bromide)2]

Conditions
ConditionsYield
In methanol for 3h; Reflux;86%
2,6-difluorophenylisothiocyanate
207974-17-2

2,6-difluorophenylisothiocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(2,6-difluorophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(2,6-difluorophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 3h;85%
2,4-diflurophenylisocyanate
59025-55-7

2,4-diflurophenylisocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(2,4-difluorophenyl)ureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(2,4-difluorophenyl)ureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 4h;85%
copper(II) choride dihydrate

copper(II) choride dihydrate

L-5-HTP
4350-09-8

L-5-HTP

[copper(II)(L-5-hydroxytryptophan)2(chloride)2]

[copper(II)(L-5-hydroxytryptophan)2(chloride)2]

Conditions
ConditionsYield
In methanol for 3h; Reflux;84.8%
nickel(II) nitrate hexahydrate

nickel(II) nitrate hexahydrate

L-5-HTP
4350-09-8

L-5-HTP

[nickel(II)(L-5-hydroxytryptophan)2(nitrate)2] methanol disolvate monohydrate

[nickel(II)(L-5-hydroxytryptophan)2(nitrate)2] methanol disolvate monohydrate

Conditions
ConditionsYield
In methanol for 3h; Reflux;84%
3,4-dichlorophenyl isothiocyanate
6590-94-9

3,4-dichlorophenyl isothiocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(3,4-dichlorophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(3,4-dichlorophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 4h;83%
cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

L-5-HTP
4350-09-8

L-5-HTP

[cobalt(II)(L-5-hydroxytryptophan)2(chloride)2] pentahydrate

[cobalt(II)(L-5-hydroxytryptophan)2(chloride)2] pentahydrate

Conditions
ConditionsYield
In methanol for 3h; Reflux;82.8%
cobalt(II) bromide

cobalt(II) bromide

L-5-HTP
4350-09-8

L-5-HTP

[cobalt(II)(L-5-hydroxytryptophan)2(bromide)2]

[cobalt(II)(L-5-hydroxytryptophan)2(bromide)2]

Conditions
ConditionsYield
In methanol for 3h; Reflux;82.6%
nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

L-5-HTP
4350-09-8

L-5-HTP

[nickel(II)(L-5-hydroxytryptophan)2(methanol)2(chloride)2] monohydrate

[nickel(II)(L-5-hydroxytryptophan)2(methanol)2(chloride)2] monohydrate

Conditions
ConditionsYield
In methanol for 3h; Reflux;82.6%
copper(II) nitrate trihydrate

copper(II) nitrate trihydrate

L-5-HTP
4350-09-8

L-5-HTP

[copper(II)(L-5-hydroxytryptophan)2(nitrate)2] monohydrate

[copper(II)(L-5-hydroxytryptophan)2(nitrate)2] monohydrate

Conditions
ConditionsYield
In methanol for 3h; Reflux;82.6%
methanol
67-56-1

methanol

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-5-HTP
4350-09-8

L-5-HTP

(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoate
203736-17-8

(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoate

Conditions
ConditionsYield
Stage #1: methanol; L-5-HTP With thionyl chloride at 0 - 20℃; for 12h;
Stage #2: di-tert-butyl dicarbonate With triethylamine In dichloromethane at 0 - 20℃; for 6h;		82%
...Expand
4-bromophenyl isocyanate
2493-02-9

4-bromophenyl isocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(4-bromophenyl)ureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(4-bromophenyl)ureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 3h;82%
3-indolylglyoxal
7269-72-9

3-indolylglyoxal

L-5-HTP
4350-09-8

L-5-HTP

6-hydroxy-1-(1H-indole-3-carbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
1350653-01-8

6-hydroxy-1-(1H-indole-3-carbonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: 3-indolylglyoxal; L-5-HTP With sulfuric acid In water at 20℃; for 10h; Pictet-Spengler cyclisation;
Stage #2: With ammonia In water at 0℃; for 12h; pH=6 - 7;		80%
1-isothiocyanato-3-trifluoromethyl-benzene
1840-19-3

1-isothiocyanato-3-trifluoromethyl-benzene

L-5-HTP
4350-09-8

L-5-HTP

3-(5-hydroxy-1H-indol-3-yl)-2-(3-(3-trifluoromethylphenyl)thioureido)propanoic acid

3-(5-hydroxy-1H-indol-3-yl)-2-(3-(3-trifluoromethylphenyl)thioureido)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 3h;80%
4-fluorophenyl isothiocyanate
1544-68-9

4-fluorophenyl isothiocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(4-fluorophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(4-fluorophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran79%
3-chloro-4-fluorophenyl isothiocyanate
137724-66-4

3-chloro-4-fluorophenyl isothiocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(3-chloro-4-fluorophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(3-chloro-4-fluorophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 4h;79%
3-bromophenyl isothiocyanate
2131-59-1

3-bromophenyl isothiocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(3-bromophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(3-bromophenyl)thioureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 3.5h;78%
zinc dibromide

zinc dibromide

L-5-HTP
4350-09-8

L-5-HTP

[zinc(II)(L-5-hydroxytryptophan)2(bromide)2] monohydrate

[zinc(II)(L-5-hydroxytryptophan)2(bromide)2] monohydrate

Conditions
ConditionsYield
In methanol for 3h; Reflux;77.2%
1,3-dimethylbarbituric acid
769-42-6

1,3-dimethylbarbituric acid

L-5-HTP
4350-09-8

L-5-HTP

5-hydroxy-L-tryptophan 1,3-dimethylbarbituric acid complex

5-hydroxy-L-tryptophan 1,3-dimethylbarbituric acid complex

Conditions
ConditionsYield
In water at 100℃; for 0.5h;77%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-5-HTP
4350-09-8

L-5-HTP

(S)-2-((tert-butoxycarbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
119768-45-5

(S)-2-((tert-butoxycarbonyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 20℃; for 2h;76%
Stage #1: di-tert-butyl dicarbonate; L-5-HTP With sodium hydrogencarbonate In water at 0 - 35℃; for 24h;
Stage #2: With citric acid In water pH=6;		58.16%
With triethylamine In 1,4-dioxane at 20℃;
[Ru(η(6)-cymene)(acetone)3](CF3SO3)2

[Ru(η(6)-cymene)(acetone)3](CF3SO3)2

trifluoroacetic acid
76-05-1

trifluoroacetic acid

L-5-HTP
4350-09-8

L-5-HTP

[(η6-p-cymene)Ru(η6-5-hydroxytryptophan)](CF3SO3)2*CF3COOH

[(η6-p-cymene)Ru(η6-5-hydroxytryptophan)](CF3SO3)2*CF3COOH

Conditions
ConditionsYield
In trifluoroacetic acid ligand was added to Ru-complex in CF3COOH, stirred for 12 h at 50°C; pptd. with Et2O, dried in vac.; elem. anal.;75%
...Expand
p-chlorphenylisocyanate
104-12-1

p-chlorphenylisocyanate

L-5-HTP
4350-09-8

L-5-HTP

2-(3-(4-chlorophenyl)ureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

2-(3-(4-chlorophenyl)ureido)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid

Conditions
ConditionsYield
With pyridine; triethylamine In tetrahydrofuran for 3.5h;75%

L-5-Hydroxytryptophan Chemical Properties

Molecular Formula: C11H12N2O3
Molecular Weight: 220.22
EINECS: 224-411-1
Flash piont: 175 °F
Refractive index: n20/D 1.4850(lit.)
Melting Point: 270 °C (dec.)(lit.)
Density: 0.902 g/mL at 25 °C(lit.)
Appearance: White to pale grey powder
Alpha: -32.5 º (c=1,H2O on dry basis)
Melting point: 270 °C (dec.)(lit.)
Storage tempreture: 2-8 °C
Water solubility: 10 mg/mL
Appearance: Colorless to pale pink crystals
Structure of L-5-Hydroxytryptophan (CAS NO.4350-09-8):
                      
IUPAC Name: (2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
Canonical SMILES: C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
Isomeric SMILES: C1=CC2=C(C=C1O)C(=CN2)C[C@@H](C(=O)O)N
InChI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
InChIKey: LDCYZAJDBXYCGN-VIFPVBQESA-N
Product Category of L-5-Hydroxytryptophan (CAS NO.4350-09-8): Pharmaceutical Raw Materials;Indoles and derivatives;Tryptophan [Trp, W];Biochemistry;Biological-modified Amino Acids;Indoles;Tryptophans;Natural Plant Extract;Biochemicals Found in Plants;Nutrition Research;Tryptophan Derivatives;Unnatural Amino Acid Derivatives

L-5-Hydroxytryptophan Uses


 L-5-Hydroxytryptophan (CAS NO.4350-09-8) is used as an antidepressant, appetite suppressant, and sleep aid.

L-5-Hydroxytryptophan Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 298mg/kg (298mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
mouse LD50 intravenous 375mg/kg (375mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
BEHAVIORAL: EXCITEMENT		 Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
mouse LD50 oral 1708mg/kg (1708mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
mouse LD50 subcutaneous 418mg/kg (418mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: TREMOR		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rabbit LD50 oral 285mg/kg (285mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rat LD50 intraperitoneal 91mg/kg (91mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA		 Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
rat LD50 intravenous 27mg/kg (27mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rat LD50 oral 243mg/kg (243mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA		 Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
rat LD50 subcutaneous 149mg/kg (149mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.

L-5-Hydroxytryptophan Safety Profile

Safety Information of L-5-Hydroxytryptophan (CAS NO.4350-09-8):
Hazard Codes: XnIrritantXiIrritant
Risk Statements: 22-36/37/38-65-20/21/22-20/21
 R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R65: Harmful: may cause lung damage if swallowed. 
R20/21: Harmful by inhalation and in contact with skin.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36-26
S36:Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YN7110000
HazardClass: 6.1
PackingGroup: III
HS Code: 29339990

L-5-Hydroxytryptophan Specification

 L-5-Hydroxytryptophan , its cas register number is 4350-09-8. It also can be called 5-Hydroxy-L-tryptophan ; Oxitriptan ; Tript-OH ; and L-Tryptophan, 5-hydroxy- . L-5-Hydroxytryptophan (CAS NO. 4350-09-8) is a naturally occurring amino acid, and is a precursor to the neurotransmitter serotonin and an intermediate in tryptophan metabolism. It is marketed in the United States and other countries as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid. However, according to a 2001 meta-analysis, no sufficient high quality research has been done to establish its effectiveness for treatment of clinical depression or dysthymia.

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