L-Glutamic acid diethyl ester hydrochloride supplier

Name
Diethyl L-glutamate hydrochloride
EINECS 214-270-4
CAS No. 1118-89-4
Article Data11
CAS DataBase
Density 1.08g/cm3
Solubility Soluble in water
Melting Point 108-110 °C
Formula C₉H₁₇NO₄^.HCl
Boiling Point 262 °C at 760 mmHg
Molecular Weight 239.699
Flash Point 86.3 °C
Transport Information
Appearance white crystalline powder
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Glutamicacid, diethyl ester, hydrochloride, L- (7CI,8CI);L-Glutamic acid, diethylester, hydrochloride (9CI);Diethylglutamate hydrochloride;Glutamic acid diethyl ester hydrochloride;NSC 12960;NSC 17007;Diethyl L-glutamate hydrochloride;
PSA 78.62000
LogP 1.72240

Synthetic route

: 56-86-0
L-glutamic acid

: 75-36-5
acetyl chloride

: 1118-89-4
diethyl-L-glutamate hydrochloride

Conditions

Conditions	Yield
In ethanol at 0℃; for 4h; Reflux;	99%

: 64-17-5
ethanol

: 56-86-0
L-glutamic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride	98%
Stage #1: ethanol; L-glutamic acid With bis(trichloromethyl) carbonate at 70 - 75℃; for 5h; Stage #2: With hydrogenchloride at 20 - 25℃; for 0.5h;	98%
Stage #1: ethanol With thionyl chloride at -10 - 10℃; for 1h; Stage #2: L-glutamic acid at 20 - 80℃; for 2h;	77.76%

: 56-86-0
L-glutamic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

Conditions

Conditions	Yield
at 190 - 195℃; unter vermindertem Druck, Kochen der gebildeten (S)-5-Oxo-pyrrolidin-carbonsaeure-(2) mit aethanol.HCl;

: 64-17-5
ethanol

: 1119-33-1
(S)-2-Amino-pentanedioic acid 5-ethyl ester

: 1118-89-4
diethyl-L-glutamate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 20℃; for 25h; Cooling with ice;

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 2,5-difluoro-4-nitrobenzoyl chloride

: 7498-31-9
diethyl N-(2,5-difluoro-4-nitrobenzoyl)-L-glutamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h;	100%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: (4-Chlorocarbonyl-3,5-difluoro-phenyl)-prop-2-ynyl-carbamic acid tert-butyl ester

: 141412-75-1
diethyl N-(4-(N-(tert-butyloxycarbonyl)-N-prop-2-ynylamino)-2,6-difluorobenzoyl)-L-glutamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h;	100%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 4-(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-benzoic acid

: 150585-92-5
diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 18h;	100%

: 38239-45-1
5-bromo-3-methyl-thiophene-2-carboxylic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 160743-92-0
2(S)-{[(5-bromo-3-methylthiophene-2-yl)carbonyl]amino}pentanedioic acid diethyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 18h;	99%

: 5781-53-3
monomethyl oxalyl chloride

: 1118-89-4
diethyl-L-glutamate hydrochloride

: (S)-2-(methoxyoxalyl-amino)pentanedioic acid diethyl ester

Conditions

Conditions	Yield
In toluene	99%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 404586-94-3
1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline

: 130696-54-7
diethyl (tert-butoxycarbonyl)-L-glutamate

Conditions

Conditions	Yield
In diethyl ether Heating;	98%

: 2389-45-9
Boc-Lys(Z)-OH

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 138680-20-3
Boc-Lys(Cbz)-Glu(Et)-OEt

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 20℃; Alkaline conditions;	98%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 16h;	77%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 16450-41-2
L-glutamic acid diethyl ester

Conditions

Conditions	Yield
With potassium carbonate In water for 0.5h;	97.5%
With Amberlyst A21 resin In dichloromethane at 0 - 20℃; for 2h;	94%
With ammonia In diethyl ether; water at 20℃; for 2h;

: 1118-89-4
diethyl-L-glutamate hydrochloride

: C64H36N4O8(2-)*Pd(2+)

: C100H96N8O20(2-)*Pd(2+)

Conditions

Conditions	Yield
With pyridine; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 24h;	96%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 133446-79-4
5-{[(2-Fluoro-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-amino]-methyl}-thiophene-2-carboxylic acid

: 133447-08-2
(S)-2-[(5-{[(2-Fluoro-ethyl)-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-yl)-amino]-methyl}-thiophene-2-carbonyl)-amino]-pentanedioic acid diethyl ester

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl-formamide for 16h; Ambient temperature;	95%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 5222-73-1
3,4-dimethoxy-3-cyclobutene-1,2-dione

: (S)-diethyl 2-((2-methoxy-3,4-dioxocyclobut-1-en-1-yl)amino)pentanedioate

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; for 24h;	95%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 137281-39-1
4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

: 146943-43-3
N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; sodium hydroxide In ethanol; water at 40℃; for 3h;	94.5%
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine at 20℃; Condensation;	62%
Stage #1: 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: diethyl-L-glutamate hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 3.5h;	62%
With 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-methylmorpholine N-oxide In N,N-dimethyl-formamide at 25℃; for 1.5h; Large scale;
With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 6h;

: 75-44-5
phosgene

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 145080-95-1
(S)-(-)-2-isocyanatoglutaric acid diethyl ester

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran; dichloromethane at 0℃; for 2h;	94%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 100-44-7
benzyl chloride

: 96-34-4
methyl chloroacetate

: N-methoxycarbonylmethyl-N-benzyl-L-glutamic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: diethyl-L-glutamate hydrochloride; methyl chloroacetate With potassium carbonate; potassium iodide In acetonitrile at 20 - 80℃; Stage #2: benzyl chloride In acetonitrile at 80℃;	93.5%

...Expand

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 83314-83-4
diethyl N-(p-nitrobenzyl)-L-glutamate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 72h; Ambient temperature;	92%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 103868-02-6
5-Nitroindole-2-carbonyl chloride

: 109707-70-2
Diethyl L-glutamate

Conditions

Conditions	Yield
With triethylamine In chloroform; ethyl acetate at 20℃; for 0.5h;	91.9%

: 2-[9,10-dioxo-4-(p-tolylamino)-9,10-dihydroanthracen-1-oxyl]acetic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: (S)-diethyl 2-{2-[9,10-dioxo-4-(p-tolylamino)-9,10-dihydroanthracen-1-oxyl]acetamido}pentanedioate

Conditions

Conditions	Yield
With 4-methyl-morpholine In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;	91.9%

: 81338-13-8
3-(N-ethyl-N-{4'-[(4''-nitrophenyl)azo]phenyl}amino)propanoic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1174937-08-6
C26H33N5O7

Conditions

Conditions	Yield
Stage #1: 3-(N-ethyl-N-{4'-[(4''-nitrophenyl)azo]phenyl}amino)propanoic acid With triethylamine In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: With chloroformic acid ethyl ester In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #3: diethyl-L-glutamate hydrochloride With triethylamine In tetrahydrofuran at 20℃; Inert atmosphere;	91%

: 16694-18-1
4-bromo-thiophene-2-carboxylic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1286279-56-8
(S)-2-[(4-bromothiophene-2-carbonyl)amino]pentanedioic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: 4-bromo-thiophene-2-carboxylic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: diethyl-L-glutamate hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 12h;	91%

: 7311-64-0
3-bromothiophene-2-carboxylic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1286279-52-4
(S)-2-[(3-bromothiophene-2-carbonyl)amino]pentanedioic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: 3-bromothiophene-2-carboxylic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: diethyl-L-glutamate hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 12h;	91%

: 696-59-3
cis,trans-2,5-dimethoxytetrahydrofuran

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 157034-04-3
(2S)-(-)-diethyl-2-(pyrrol-1-yl)-pentanedioate

Conditions

Conditions	Yield
In water; 1,2-dichloro-ethane at 80℃; for 2h;	90%
In water; 1,2-dichloro-ethane at 80℃; for 0.75h;	81%
In water; 1,2-dichloro-ethane at 80℃; for 0.75h;	81%
In water; 1,2-dichloro-ethane at 80℃; for 0.833333h;	80%
In water at 80℃; for 0.5h;	62%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 5-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-methyl]-pyridine-2-carboxylic acid

: 133447-11-7
(S)-2-({5-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-methyl]-pyridine-2-carbonyl}-amino)-pentanedioic acid diethyl ester

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl-formamide for 16h; Ambient temperature;	90%

: 24424-99-5
di-tert-butyl dicarbonate

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 130696-54-7
diethyl (tert-butoxycarbonyl)-L-glutamate

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 0 - 55℃; for 15.25h;	90%
With triethylamine at 20℃; for 48h; Acylation;	34%
With triethylamine; dmap In acetonitrile at 20℃;

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1079-66-9
chloro-diphenylphosphine

: 368879-75-8
(S)-N-diphenylphosphinoglutamic acid diethyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 5℃; for 3h;	90%
With triethylamine

: 1118-89-4
diethyl-L-glutamate hydrochloride

: C22H26N4O5

: 425663-99-6
(R,S)-N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 6h;	90%

: 1174937-13-3
2-{p-[2'-methoxy-4'-(p-nitrophenylazo)phenylazo]phenoxy}-acetic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1174937-14-4
N-(2-{4-[2'-methoxy-4'-(p-nitrophenylazo)phenylazo]phenoxy}-acetyl)-glutamic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: 2-{p-[2'-methoxy-4'-(p-nitrophenylazo)phenylazo]phenoxy}-acetic acid With triethylamine In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: With chloroformic acid ethyl ester In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #3: diethyl-L-glutamate hydrochloride With triethylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	90%

: 100523-84-0
2-bromothiophene-4-carboxylic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1286279-58-0
(S)-2-[(5-bromothiophene-3-carbonyl)amino]pentanedioic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: 2-bromothiophene-4-carboxylic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: diethyl-L-glutamate hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 12h;	90%

: 24287-95-4
2-bromothiophene-3-carboxylic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 1286279-50-2
(S)-2-[(2-bromothiophene-3-carbonyl)amino]pentanedioic acid diethyl ester

Conditions

Conditions	Yield
Stage #1: 2-bromothiophene-3-carboxylic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: diethyl-L-glutamate hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 12h;	90%

L-Glutamic acid diethyl ester hydrochloride Specification

L-Glutamic acid diethyl ester hydrochloride, with the CAS register number 1118-89-4, could also be known to us as diethylester, hydrochloride,l-glutamicaci; diethyll-glutaminatehydrochloride; l-glutamic acid alpha,gamma-diester hydrochloride; l-glutamic acid alpha, gamma-diethyl ester hydrochloride; glutamic acid(oet)-oet hcl; h-glu(oet)-oet hcl ,etc. It is a white crystalline powder and if you need the safety information, you could refer to the WGK Germany 3 to get some. As for its usage, it is uaually used in the organic synthesis and pharmaceutical intermediates. The product categories of this chemical are as below: glutamic acid [glu, e], amino acids and derivatives, amino acid ethyl esters, biochemistry, amino hydrochloride, glutamic acidneurotransmitters, excitatory amino acids, neurotransmitters, peptide synthesis.

Physical properties about L-Glutamic acid diethyl ester hydrochloride are: (1)#H bond acceptors: 5; (2)#H bond donors: 2; (3)#Freely Rotating Bonds: 9; (4)Polar Surface Area: 55.84; (5)Index of Refraction: 1.452; (6)Molar Refractivity: 50.78 cm³; (7)Molar Volume: 188.1 cm³; (8)Polarizability: 20.13 ×10-24cm³; (9)Surface Tension: 37.6 dyne/cm; (10)Density: 1.08 g/cm³; (11)Flash Point: 86.3 °C; (12)Enthalpy of Vaporization: 49.97 kJ/mol; (13)Boiling Point: 262 °C at 760 mmHg; (14)Vapour Pressure: 0.0112 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C9H17NO4.ClH/c1-3-13-8(11)6-5-7(10)9(12)14-4-2;/h7H,3-6,10H2,1-2H3;1H/t7-;/m0./s1;
(2)InChIKey=WSEQLMQNPBNMSL-FJXQXJEOSA-N;
(3)SmilesO(C(=O)[C@H](CCC(OCC)=O)N)CC.Cl

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)		Pharmaceutical Chemistry Journal Vol. 25, Pg. 246, 1991.

Product Name

Diethyl L-glutamate hydrochloride

Synthetic route

L-Glutamic acid diethyl ester hydrochloride Specification

Related Products

Hot Products