• Name

  Loperamide hydrochloride

• EINECS 252-082-4
• CAS No. 34552-83-5
• Density ==
• Solubility
• Melting Point 223-225 °C
• Formula C₂₉H₃₃ClN₂O₂^.HCl
• Boiling Point 647.2 °C at 760 mmHg
• Molecular Weight 513.507
• Flash Point 345.2 °C
• Transport Information UN 2811 6.1/PG 3
• Appearance White solid
• Safety 45
• Risk Codes 25
• Molecular Structure
• Hazard Symbols T
• Synonyms Imodium;1-Piperidinebutanamide,4-(4-chlorophenyl)-4- hydroxy-N,N-dimethyl-R,R-diphenyl-,monohydrochloride;Imodium (TN);Lopemin;Prestwick_302;4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-N,N-dimethyl-2,2-diphenyl-butanamide hydrochloride;R 18553;Loperamide hydrochloride (JAN/USP);Loperamide HCl;
• PSA 43.78000
• LogP 5.82790

Synthetic route

39512-49-7

4-(4-chlorophenyl)-4-hydroxypiperidine

37743-18-3

N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide

34552-83-5

loperamide hydrochloride

Conditions

Conditions	Yield
Stage #1: 4-(4-chlorophenyl)-4-hydroxypiperidine With sodium carbonate; potassium iodide In 1,3-dioxolane-4-methanol for 0.25h; Stage #2: N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide In 1,3-dioxolane-4-methanol at 60℃; for 2h; Stage #3: With hydrogenchloride In 1,3-dioxolane-4-methanol; isopropyl alcohol for 0.333333h;	67%

39512-49-7

4-(4-chlorophenyl)-4-hydroxypiperidine

37743-18-3

N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide

108-10-1

4-methyl-2-pentanone

34552-83-5

loperamide hydrochloride

Conditions

Conditions	Yield
With potassium iodide; sodium carbonate In hydrogenchloride; isopropyl alcohol; acetone; toluene

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34552-83-5

loperamide hydrochloride

74-88-4

methyl iodide

C31H38ClN2O2(1+)*I(1-)

C31H38ClN2O2(1+)*I(1-)

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; sodium hydroxide In dichloromethane; water at 20℃; Inert atmosphere;	A 14% B 44%

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LOPERAMIDE HYDROCHLORIDE Chemical Properties

The Molecular formula of LOPERAMIDE HYDROCHLORIDE(34552-83-5): C₂₉H₃₄Cl₂N₂O₂
The Molecular Weight of LOPERAMIDE HYDROCHLORIDE(34552-83-5): 513.5
The Molecular Structure of LOPERAMIDE HYDROCHLORIDE(34552-83-5): 
EINECS: 252-082-4
Melting point: 223-225^°C
Boiling Point: 647.2 °C at 760 mmHg  
Flash Point: 345.2 °C 
Enthalpy of Vaporization: 100.3 kJ/mol 
Vapour Pressure: 1.23E-17 mmHg at 25°C 
Appearance: White Solid
IUPAC Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Synonyms: 4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINEBUTANAMIDE HYDROCHLORIDE;4-(4-chlorophenyl)-4-hydroxy-n,n-dimethyl-alpha,alpha-;LOPERAMIDE HYDROCHLORIDE;4-(4-CHLOROPHENYL)-4-HYDROXY-N,N-DIMETHYL-ALPHA,ALPHA-DIPHENYL-1-PIPERIDINBUTYRAMIDE HYDROCHLORIDE;LABOTEST-BB LT00134703;LOSERAMIN;LOPERAMIDE HCL;

LOPERAMIDE HYDROCHLORIDE Uses

LOPERAMIDE HYDROCHLORIDE Toxicity Data With Reference

LOPERAMIDE HYDROCHLORIDE Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl⁻, NO_x, and HCl.}
The Hazard Codes of LOPERAMIDE HYDROCHLORIDE(34552-83-5):  T
HazardClass: 6.1(b)
The Risk Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
25:  Toxic if swallowed
The Safety Statements information of LOPERAMIDE HYDROCHLORIDE(34552-83-5):
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TM4960000
PackingGroup: III