• Name

  MAEM

• EINECS 279-540-6
• CAS No. 84994-24-1
• Density 1.63g/cm³
• Solubility
• Melting Point
• Formula C13H10 N4 O3 S2
• Boiling Point 563.2°C at 760 mmHg
• Molecular Weight 350.44
• Flash Point 294.4°C
• Transport Information
• Appearance
• Safety
• Risk Codes  Xi:Irritant;
  
• Molecular Structure
• Hazard Symbols R36/37/38:;
• Synonyms 4-Thiazoleaceticacid, 2-amino-a-(methoxyimino)-,2-benzothiazolyl ester, (Z)-;(Z)-2-[Methoxyimino]-2-(2-aminothiazol-4-yl)acetic acid;(Z)-2-[Methoxyimino]-2-(2-aminothiazol-4-yl)acetic acid 2-benzothiazole ester
• PSA 171.19000
• LogP 3.67310

Synthetic route

84994-24-1

2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester

7-amino-3-[2-(5-methyl-2H-tetrazolyl)methyl]cephalosporanic acid

82547-58-8

cefteram

Conditions

Conditions	Yield
With sodium metabisulfite; triethylamine In methanol; dichloromethane at 0℃; for 3h;	89.1%

7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid

7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid

84994-24-1

2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester

A

104146-53-4

7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt

B

104146-16-9

7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt

Conditions

Conditions

Yield

Stage #1: 7-amino-3-[2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; 7-amino-3-[(E)-2-(4-methyl-5-thiazolyl)vinyl]-3-cephem-4-carboxylic acid; 2-methoxyimino-2-(2-aminothiazol-4-yl)acetic acid S-2-benzothiazole ester With triethylamine In water; acetone at 0 - 15℃; for 3 - 4h; Stage #2: With sodium 2-ethylhexanoic acid In water; acetone at 20 - 25℃; for 1h; Product distribution / selectivity;

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MAEM Chemical Properties

MAEM Uses

MAEM Production