Product Name

  • Name

    METHYL 2-FLUOROACRYLATE

  • EINECS
  • CAS No. 2343-89-7
  • Article Data34
  • CAS DataBase
  • Density 1.057 g/cm3
  • Solubility Slightly soluble in water.
  • Melting Point
  • Formula C4H5FO2
  • Boiling Point 75.9 °C at 760 mmHg
  • Molecular Weight 104.081
  • Flash Point 1.1 °C
  • Transport Information UN 1993
  • Appearance
  • Safety 16-26-36
  • Risk Codes 10-36/37/38
  • Molecular Structure Molecular Structure of 2343-89-7 (METHYL 2-FLUOROACRYLATE)
  • Hazard Symbols IrritantXi
  • Synonyms Acrylicacid, 2-fluoro-, methyl ester (6CI,7CI,8CI);Methyl a-fluoroacrylate;a-Fluoroacrylic acid methyl ester;
  • PSA 26.30000
  • LogP 0.64260

Synthetic route

Methyl 2-Fluoro-3-(4-toluenesulfonyloxy)propanoate
85345-88-6

Methyl 2-Fluoro-3-(4-toluenesulfonyloxy)propanoate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With potassium phtalimide at -78 - 150℃; under 0.01 Torr;97%
Methyl 3-chloro-2-fluoropropanoate
55900-27-1

Methyl 3-chloro-2-fluoropropanoate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; sodium phosphate In 1-methyl-pyrrolidin-2-one at 150℃; under 112.511 - 225.023 Torr;95%
With dimethyl amine In diethyl ether; benzene
methanol
67-56-1

methanol

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With thionyl chloride at 5 - 35℃; for 2h; Concentration; Reagent/catalyst;93%
dimethyl 2-fluoro-2-chloromethylmalonate

dimethyl 2-fluoro-2-chloromethylmalonate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; sodium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; under 225.023 Torr; for 4h;92%
methanol
67-56-1

methanol

1-chloro-1-fluoroethane
2317-91-1

1-chloro-1-fluoroethane

carbon monoxide
201230-82-2

carbon monoxide

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With dichloro[ferrocene-1,1'-diylbis(diisopropylphosphine-P)]palladium(II); triethylamine at 100℃; under 5250.53 Torr; for 8h; Reagent/catalyst; Autoclave;91.8%
With bis(tri-t-butylphosphine)palladium(0) at 100℃; for 18h; Reagent/catalyst; Time; Autoclave;77.4%
methanol
67-56-1

methanol

1-bromo-1-fluoroethylene
420-25-7

1-bromo-1-fluoroethylene

carbon monoxide
201230-82-2

carbon monoxide

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; lithium carbonate; triethylamine at 90℃; for 6h; Reagent/catalyst; Temperature; Autoclave;90.7%
With dichloro[4,5-bis(diphenylphosphino)-9,9’-dimethylxanthene]palladium(II); triethylamine at 100℃; under 7500.75 Torr; for 8h; Reagent/catalyst; Autoclave;90.1%
With bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; lithium carbonate at 90℃; under 7500.75 Torr; for 6h; Reagent/catalyst; Autoclave;71.8 g
1-chloro-1-fluoro-2,2-dimethoxycyclopropane

1-chloro-1-fluoro-2,2-dimethoxycyclopropane

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; methoxybenzene at 120 - 130℃; under 500 Torr; Reagent/catalyst; Temperature;89.5%
With 2,6-di-tert-butyl-4-methyl-phenol at 145℃; under 360 Torr;12.3 g
methyl 3-bromo-2-fluoro-2-chloropropanoate
2365-93-7

methyl 3-bromo-2-fluoro-2-chloropropanoate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 10H-phenothiazine; sulfuric acid; zinc In water at 82 - 86℃; for 0.333333h;85%
With hydrogen sulfide; sodium N-nitroso-N-phenylhydroxylaminate; zinc In water at 100℃;82%
With zinc80%
With sulfuric acid; zinc
C13H13FO6

C13H13FO6

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 10H-phenothiazine In sulfolane at 180℃; for 6h;83.9%
C14H15FO6

C14H15FO6

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 4-methoxy-phenol at 170℃; for 9h;81.2%
C14H25FO5

C14H25FO5

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 10H-phenothiazine at 170℃; for 15h;81.2%
formaldehyd
50-00-0

formaldehyd

methyl fluoroacetate
453-18-9

methyl fluoroacetate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
Stage #1: methyl fluoroacetate With Dimethyl oxalate; sodium methylate In dimethyl sulfoxide at 15 - 25℃; for 1h; Inert atmosphere;
Stage #2: formaldehyd With 2,6-di-tert-butyl-4-methyl-phenol In dimethyl sulfoxide at 20 - 35℃; for 1h; Temperature; Reagent/catalyst; Inert atmosphere;
79.3%
Stage #1: methyl fluoroacetate With Dimethyl oxalate; sodium methylate In methanol; pentane at 20 - 25℃; for 24.25h; Claisen Condensation;
Stage #2: formaldehyd In pentane at 5 - 10℃; for 5h; Concentration; Reagent/catalyst; Temperature; Time;
58%
methyl 2R,3S-2,3-difluoro-2,3-dichloropropionate
67832-56-8, 76497-87-5, 76548-29-3

methyl 2R,3S-2,3-difluoro-2,3-dichloropropionate

A

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

B

methyl Z-α,β-difluoropropenoate
1660-56-6

methyl Z-α,β-difluoropropenoate

Conditions
ConditionsYield
With sulfuric acid; zinc at 100℃;A 10%
B 75%
methyl α,β-dibromo-α-fluoropropionate
380-26-7

methyl α,β-dibromo-α-fluoropropionate

A

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

B

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

Conditions
ConditionsYield
With thiourea; zinc In diphenylether at 95℃; under 20 Torr;A 74%
B n/a
C13H15FO7S

C13H15FO7S

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol In sulfolane at 140℃; for 17h;73.8%
methyl α-bromo-α-fluoropropionate

methyl α-bromo-α-fluoropropionate

A

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

B

methyl 2,2-difluoropropanoate
38650-84-9

methyl 2,2-difluoropropanoate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; hydrogen fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 50℃; for 48h; Solvent; Temperature; Reagent/catalyst; Cooling with ice;A 23%
B 73%
methanol
67-56-1

methanol

1-bromo-1-fluoroethylene
420-25-7

1-bromo-1-fluoroethylene

carbon monoxide
201230-82-2

carbon monoxide

A

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

B

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With dichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); triethylamine at 100℃; under 7500.75 Torr; for 13h; Autoclave;A 14.1%
B 70.9%
methyl α-bromo-α-fluoropropionate

methyl α-bromo-α-fluoropropionate

A

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

B

2,2-difluoropropanoic acid
373-96-6

2,2-difluoropropanoic acid

C

methyl 2,2-difluoropropanoate
38650-84-9

methyl 2,2-difluoropropanoate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; hydrogen fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 72h; Reagent/catalyst; Solvent; Temperature; Cooling with ice;A 18%
B 5%
C 70%
dimethyl 2-fluoro-2-(hydroxymethyl)malonate
107843-23-2

dimethyl 2-fluoro-2-(hydroxymethyl)malonate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With sulfolane; potassium fluoride; 2,6-di-tert-butyl-4-methyl-phenol at 90 - 105℃; under 760.051 Torr; for 1.25h;70%
With 2,6-di-tert-butyl-4-methyl-phenol; sodium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; under 225.023 Torr;24 g
methyl (2R,3R)-2,3-difluoro-2,3-dichloropropionate
76548-29-3

methyl (2R,3R)-2,3-difluoro-2,3-dichloropropionate

A

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

B

methyl Z-α,β-difluoropropenoate
1660-56-6

methyl Z-α,β-difluoropropenoate

C

methyl α,β-difluoroacrylate
76474-26-5

methyl α,β-difluoroacrylate

Conditions
ConditionsYield
With sulfuric acid; zinc at 100℃;A 10%
B 64%
C 10%
2,3-Dichlor-2-fluor-propansaeuremethylester
53510-07-9

2,3-Dichlor-2-fluor-propansaeuremethylester

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With sulfuric acid; water; zinc at 100 - 110℃;52%
2,3-difluoropropionic acid methyl ester
4447-55-6

2,3-difluoropropionic acid methyl ester

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With sodium fluoride at 30℃; for 3h;46.9%
methanol
67-56-1

methanol

Vinylidene fluoride
75-38-7

Vinylidene fluoride

carbon monoxide
201230-82-2

carbon monoxide

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
Stage #1: methanol With bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine; lithium iodide In 1,4-dioxane at -78 - 30℃; for 1.5h; Autoclave; Sealed tube; Inert atmosphere;
Stage #2: Vinylidene fluoride; carbon monoxide In 1,4-dioxane at 90℃; under 3000.3 Torr; for 24h; Concentration; Solvent; Temperature; Autoclave; Sealed tube;
5%
methyl 3-bromo-2-fluoropropionate
399-86-0

methyl 3-bromo-2-fluoropropionate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With dimethyl amine In diethyl ether; benzene
cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

A

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

(1S,2R,4S)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester

(1S,2R,4S)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester

(1R,2R,4R)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester

(1R,2R,4R)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With thiourea; zinc 1.) diphenyl ether, 95 deg C, 20 Torr, 2.) room temperature; Yield given. Multistep reaction. Yields of byproduct given;
methyl α-bromo-α-fluoropropionate

methyl α-bromo-α-fluoropropionate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 10H-phenothiazine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 70℃; for 5h; Product distribution / selectivity;
formaldehyd
50-00-0

formaldehyd

C6H6FO5(1-)*Na(1+)

C6H6FO5(1-)*Na(1+)

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
Stage #1: C6H6FO5(1-)*Na(1+) In dimethyl sulfoxide for 0.333333h; Molecular sieve;
Stage #2: formaldehyd In dimethyl sulfoxide at 40℃; for 1.5h; Molecular sieve;
19 g
1,1-dimethoxyethylene
922-69-0

1,1-dimethoxyethylene

Dichlorofluoromethane
75-43-4

Dichlorofluoromethane

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
Stage #1: 1,1-dimethoxyethylene; Dichlorofluoromethane With tetrabutylammomium bromide; potassium hydroxide In hexane; water at 5 - 10℃;
Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol at 0 - 145℃; under 360 Torr;
dimethyl 2-fluoro-2-chlorosulfinyloxymethylmalonate

dimethyl 2-fluoro-2-chlorosulfinyloxymethylmalonate

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methyl-phenol; sodium carbonate In 1-methyl-pyrrolidin-2-one at 130℃; under 225.023 Torr; for 4h;
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

3-methoxy-1-iodobenzene
766-85-8

3-methoxy-1-iodobenzene

(Z)-methyl 2-fluoro-3-(3-methoxyphenyl)acrylate

(Z)-methyl 2-fluoro-3-(3-methoxyphenyl)acrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;99%
ortho-methylphenyl iodide
615-37-2

ortho-methylphenyl iodide

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

(Z)-methyl 2-fluoro-3-(2-methylphenyl)acrylate

(Z)-methyl 2-fluoro-3-(2-methylphenyl)acrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;99%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

o-iodo-methyl-benzoic acid
610-97-9

o-iodo-methyl-benzoic acid

(Z)-methyl 2-(2-fluoro-3-methoxy-3-oxoprop-1-en-1-yl)benzoate

(Z)-methyl 2-(2-fluoro-3-methoxy-3-oxoprop-1-en-1-yl)benzoate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;99%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

2-iodonaphthalene
612-55-5

2-iodonaphthalene

(Z)-methyl 2-fluoro-3-(naphth-2-yl)acrylate
1075204-23-7

(Z)-methyl 2-fluoro-3-(naphth-2-yl)acrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;99%
iodobenzene
591-50-4

iodobenzene

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

methyl (Z)-2-fluoro-3-phenylpropenoate
370-07-0, 56695-79-5, 56695-78-4

methyl (Z)-2-fluoro-3-phenylpropenoate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Reagent/catalyst; Temperature; Heck Reaction; stereospecific reaction;99%
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Sealed tube; Inert atmosphere;
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

(Z)-methyl 3-(4-fluorophenyl)-2-fluoroacrylate

(Z)-methyl 3-(4-fluorophenyl)-2-fluoroacrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;99%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

4-Iodobenzotrifluoride
455-13-0

4-Iodobenzotrifluoride

methyl Z-2-fluoro-3-(4-trifluoromethylphenyl)prop-2-enoate
126976-31-6

methyl Z-2-fluoro-3-(4-trifluoromethylphenyl)prop-2-enoate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;99%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

2-6-dimethoxybenzoic acid
1466-76-8

2-6-dimethoxybenzoic acid

(Z)-methyl 2-fluoro-3-(2,6-dimethoxyphenyl)acrylate

(Z)-methyl 2-fluoro-3-(2,6-dimethoxyphenyl)acrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; diastereoselective reaction;98%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

octadec-1-ene
112-88-9

octadec-1-ene

methyl (Z)-2-fluorononadec-2-enoate

methyl (Z)-2-fluorononadec-2-enoate

Conditions
ConditionsYield
With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) In dichloromethane at 80℃; for 15h; Cross Metathesis; Inert atmosphere; Sealed tube; diastereoselective reaction;98%
propylamine
107-10-8

propylamine

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

N-(n-propyl)-α-fluoroacrylamide
1378386-19-6

N-(n-propyl)-α-fluoroacrylamide

Conditions
ConditionsYield
In methanol at 20℃; for 24h;96.14%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine
93102-05-7

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

methyl 1-benzyl 3-fluoropyrrolidine-3-carboxylate
1279669-60-1

methyl 1-benzyl 3-fluoropyrrolidine-3-carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 4h;95%
With trifluoroacetic acid In dichloromethane at 20℃; for 4h; Inert atmosphere;80%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

1-(1,1-dimethylethyl)-1H-indole-1,2-dicarboxylic acid 2-methyl ester
163229-48-9

1-(1,1-dimethylethyl)-1H-indole-1,2-dicarboxylic acid 2-methyl ester

C19H22FNO6

C19H22FNO6

Conditions
ConditionsYield
With [Ir(dF(Me)ppy)2dtbbpy]PF6 In tetrahydrofuran at 28℃; Inert atmosphere; Glovebox; Irradiation;93%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

(R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine
133407-38-2

(R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine

methyl 3-fluoro-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate
1461698-11-2

methyl 3-fluoro-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;92%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

2-Methoxybenzoic acid
579-75-9

2-Methoxybenzoic acid

methyl (2Z)-2-fluoro-3-(2-methoxyphenyl)acrylate

methyl (2Z)-2-fluoro-3-(2-methoxyphenyl)acrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 120℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Time; Sealed tube; diastereoselective reaction;92%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

N-methylaniline
100-61-8

N-methylaniline

3-fluoro-1-phenylpyrrolidin-2-one

3-fluoro-1-phenylpyrrolidin-2-one

Conditions
ConditionsYield
With Quinuclidine; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In acetonitrile for 16h; Sealed tube; Inert atmosphere; Irradiation;92%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride
677728-84-6

3,5-difluoro-N-hydroxybenzenecarboximidoyl chloride

methyl 3-(3,5-difluorophenyl)-5-fluoro-4,5-dihydro-1,2-oxazole-5-carboxylate

methyl 3-(3,5-difluorophenyl)-5-fluoro-4,5-dihydro-1,2-oxazole-5-carboxylate

Conditions
ConditionsYield
With sodium hydrogencarbonate In isopropyl alcohol at 40℃; for 1h;91%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

4-iodobenzonitrile
3058-39-7

4-iodobenzonitrile

methyl Z-3-(4-cyanophenyl)-2-fluoroprop-2-enoate
126976-32-7

methyl Z-3-(4-cyanophenyl)-2-fluoroprop-2-enoate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; stereospecific reaction;90%
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Sealed tube; Inert atmosphere;
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

1,4-bromoiodobenzene
589-87-7

1,4-bromoiodobenzene

(Z)-methyl 3-(4-bromophenyl)-2-fluoroacrylate

(Z)-methyl 3-(4-bromophenyl)-2-fluoroacrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane at 90℃; for 4h; Heck Reaction; chemoselective reaction;89%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

(Z)-methyl 2-fluoro-3-(2,4,6-trimethylphenyl)acrylate

(Z)-methyl 2-fluoro-3-(2,4,6-trimethylphenyl)acrylate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; silver carbonate In 1,4-dioxane; dimethyl sulfoxide at 120℃; for 12h; Sealed tube; diastereoselective reaction;89%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

Conditions
ConditionsYield
Stage #1: methyl 2-fluoroprop-2-enoate With sodium hydroxide In ethanol; water for 0.5h; pH=11; Inert atmosphere;
Stage #2: With hydrogenchloride In diethyl ether; water Inert atmosphere;
87%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

4-Phenyl-1-butene
768-56-9

4-Phenyl-1-butene

A

(Z)-methyl 2-fluoro-4-phenyl-2-butenoate
113924-47-3

(Z)-methyl 2-fluoro-4-phenyl-2-butenoate

B

methyl (Z)-2-fluoro-5-phenylpent-2-enoate

methyl (Z)-2-fluoro-5-phenylpent-2-enoate

Conditions
ConditionsYield
With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) In chloroform at 80℃; for 15h; Reagent/catalyst; Solvent; Cross Metathesis; Inert atmosphere; Sealed tube; diastereoselective reaction;A n/a
B 87%
methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

1-(but-3-en-1-yl)-2-methoxybenzene
63667-83-4

1-(but-3-en-1-yl)-2-methoxybenzene

methyl (Z)-2-fluoro-5-(2-methoxyphenyl)pent-2-enoate

methyl (Z)-2-fluoro-5-(2-methoxyphenyl)pent-2-enoate

Conditions
ConditionsYield
With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) In dichloromethane at 80℃; for 15h; Cross Metathesis; Inert atmosphere; Sealed tube; diastereoselective reaction;87%
1-Decene
872-05-9

1-Decene

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

methyl (Z)-2-fluoroundeca-2-enoate

methyl (Z)-2-fluoroundeca-2-enoate

Conditions
ConditionsYield
With [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro-(3-phenyl-1H-inden-1-ylidene)(tricyclohexylphosphine)ruthenium(II) In dichloromethane at 80℃; for 15h; Cross Metathesis; Inert atmosphere; Sealed tube; diastereoselective reaction;87%

Methyl 2-fluoroacrylate Specification

The cas register number of Methyl 2-fluoroacrylate is 2343-89-7. In addition, the molecular formula is C4H5FO2 and the molecular weight is 104.08. The systematic name about this chemical is methyl 2-fluoroprop-2-enoate. Besides, it is a irritating chemical and should be stored in a cool and dry place.

Physical properties about Methyl 2-fluoroacrylate are: (1)ACD/LogP: 0.68; (2)ACD/LogD (pH 5.5): 0.68; (3)ACD/LogD (pH 7.4): 0.68; (4)ACD/BCF (pH 5.5): 1.95; (5)ACD/BCF (pH 7.4): 1.95; (6)ACD/KOC (pH 5.5): 56.12; (7)ACD/KOC (pH 7.4): 56.12; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 2; (10)Polar Surface Area: 26.3 Å2; (11)Index of Refraction: 1.366; (12)Molar Refractivity: 22.08 cm3; (13)Molar Volume: 98.3 cm3; (14)Polarizability: 8.75 ×10-24cm3; (15)Surface Tension: 21 dyne/cm; (16)Density: 1.057 g/cm3; (17)Flash Point: 1.1 °C; (18)Enthalpy of Vaporization: 31.7 kJ/mol; (19)Boiling Point: 75.9 °C at 760 mmHg; (20)Vapour Pressure: 103 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable and it is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. And you should keep away from sources of ignition. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: F/C(=C)C(=O)OC 
(2)Std. InChI: InChI=1S/C4H5FO2/c1-3(5)4(6)7-2/h1H2,2H3
(3)Std. InChIKey: ZTZJVAOTIOAZGZ-UHFFFAOYSA-N

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