• Name

  Methyl benzoylformate

• EINECS 239-263-3
• CAS No. 15206-55-0
• Article Data291
• CAS DataBase
• Density 1.164 g/cm³
• Solubility 2g/L at 20℃
• Melting Point 16 °C
• Formula C₉H₈O₃
• Boiling Point 247 °C at 760 mmHg
• Molecular Weight 164.161
• Flash Point 103.8 °C
• Transport Information
• Appearance light yellow liquid
• Safety 24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Benzeneacetic acid,R-oxo-,methyl ester;Phenylglyoxylic acid, methyl ester;methyl 2-oxo-2-phenyl-acetate;Benzeneacetic acid, .alpha.-oxo-, methyl ester;Glyoxylic acid, phenyl-, methyl ester;Methyl-α-oxo-phenylacetate;Vicure 55;
• PSA 43.37000
• LogP 1.04230

Synthetic route

4358-87-6

(RS)-methyl mandelate

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; oxygen; copper(I) bromide dimethylsulfide complex In chlorobenzene at 90℃; for 7h;	100%
With sodium hydrogencarbonate; sodium bromide In dichloromethane at 20℃; Electrochemical reaction;	99%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; calcium methylate In acetonitrile at 0 - 20℃;	99%

4249-72-3

2-phenoxy-1-phenylethanol

A

93-58-3

benzoic acid methyl ester

B

15206-55-0

methyl 2-oxo-2-phenylacetate

C

108-95-2

phenol

Conditions

Conditions	Yield
With oxygen In methanol at 80 - 120℃;	A 66% B 34% C 100%

...Expand

67-56-1

methanol

21132-27-4

2-(4-methoxyphenyl)-4-phenyl-1,3-dithiol-1-ium-5-olate

A

15206-55-0

methyl 2-oxo-2-phenylacetate

B

15088-73-0

4-methoxybenzoic dithioperoxyanhydride

Conditions

Conditions	Yield
With 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; oxygen In methanol; benzene for 1h; Irradiation;	A 43% B 99%

...Expand

67-56-1

methanol

20850-89-9

2,5-diphenyl-1,3-dithiolylium-4-olate

A

15206-55-0

methyl 2-oxo-2-phenylacetate

B

644-32-6

dibenzoyl disulfide

Conditions

Conditions	Yield
With 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; oxygen In methanol; benzene at 10℃; for 1.25h; Irradiation;	A 28% B 99%

...Expand

21132-27-4

2-(4-methoxyphenyl)-4-phenyl-1,3-dithiol-1-ium-5-olate

A

15206-55-0

methyl 2-oxo-2-phenylacetate

B

15088-73-0

4-methoxybenzoic dithioperoxyanhydride

Conditions

Conditions	Yield
With 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; oxygen In methanol; benzene for 1h; Irradiation;	A 43% B 99%

20850-89-9

2,5-diphenyl-1,3-dithiolylium-4-olate

A

15206-55-0

methyl 2-oxo-2-phenylacetate

B

644-32-6

dibenzoyl disulfide

Conditions

Conditions	Yield
With 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; oxygen In methanol; benzene at 10℃; for 1.25h; Irradiation;	A 28% B 99%

614-27-7

methyl 3-oxo-3-phenylpropionate

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
With aluminum (III) chloride; Oxone In water at 20℃; for 24h;	98%
With iodine; dimethyl sulfoxide; copper(ll) bromide for 8h; Schlenk technique; Heating;	81%

51863-47-9

(diethoxyphosphoryl)-phenyl-acetic acid methyl ester

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
Stage #1: (diethoxyphosphoryl)-phenyl-acetic acid methyl ester With sodium t-butanolate In N,N-dimethyl-formamide at 25℃; for 0.0833333h; Inert atmosphere; Stage #2: With oxygen In N,N-dimethyl-formamide at 25℃; for 8h; stereoselective reaction;	96%

67-56-1

methanol

611-73-4

Benzoylformic acid

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
With hydrogen-type cation exchange resin at 80℃; under 675.068 Torr; for 2h; Pressure; Temperature;	95.5%
With sulphate-doped anatase In cyclohexane Concentration; Reflux; Industrial scale;	92.5%
With chloro-trimethyl-silane In tetrahydrofuran at 22℃; for 72h;	89%

613-90-1

benzoyl cyanide

67-56-1

methanol

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
Stage #1: benzoyl cyanide With sulfuric acid; tetrabutylammomium bromide; ammonium chloride In para-xylene at 20 - 40℃; for 2h; Stage #2: methanol In para-xylene at 40 - 90℃; for 3.5h; Reagent/catalyst; Temperature; Solvent;	95%
With hydrogenchloride Behandeln mit Wasser;
With sulfuric acid; acetic anhydride; sodium bromide 1.) 70 deg C; Yield given. Multistep reaction;
at 55 - 65℃; for 1h;	449 g

67-56-1

methanol

1074-12-0

phenylglyoxal hydrate

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
With iodine; potassium carbonate In toluene at 20℃; for 1h; Green chemistry;	95%
With 2-Picolinic acid; copper(l) iodide; oxygen at 20℃; for 12h; Irradiation;	90%
With 2,2,6,6-tetramethyl-piperidine; 4-nitro-phenol; oxygen; potassium iodide for 11.5h; Electrochemical reaction;	67%
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide In acetonitrile at 80℃; for 8h;	56%
With 1,3-bis(2,4,6-trimethylphenyl)imidazolinium-2-carboxylate; carbon dioxide In tetrahydrofuran at -70 - 60℃; under 7500.75 Torr; Product distribution / selectivity; Inert atmosphere; Sealed tube;	31%

186581-53-3, 908094-01-9

diazomethane

611-71-2, 611-72-3, 17199-29-0, 90-64-2

MANDELIC ACID

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
With 2-azatricyclo[3.3.1.13,7]dec-2-yloxidanyl; sodium nitrite In aq. phosphate buffer; water; acetonitrile at 25℃; for 2h; chemoselective reaction;	95%

67-56-1

methanol

582-24-1

1-phenyl-2-hydroxyethanone

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
With oxygen at 70℃; for 12h; Schlenk technique; Sealed tube;	95%

32569-87-2

4-methoxyl-phenylacetylene

15206-55-0

methyl 2-oxo-2-phenylacetate

Conditions

Conditions	Yield
With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); 2,3-dichloropyridine N-oxide at 20℃; for 10.1667h;	95%

67-56-1

methanol

Conditions

Conditions	Yield
With pyridine In benzene at 0℃; for 0.5h;	94%

Methyl benzoylformate Chemical Properties

Methyl benzoylformate Safety Profile