• Name

  (1-METHYL-1H-IMIDAZOL-4-YL)-ACETIC ACID

• EINECS
• CAS No. 2625-49-2
• Density 1.27 g/cm³
• Solubility
• Melting Point 187-189 °C
• Formula C₆H₈N₂O₂
• Boiling Point 384.4 °C at 760mmHg
• Molecular Weight 140.142
• Flash Point 186.3 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Imidazole-4-aceticacid, 1-methyl- (6CI,7CI,8CI);(1-Methyl-1H-imidazol-4-yl)acetic acid;(1-Methylimidazol-4-yl)acetic acid;1-Methylimidazole-4-acetic acid;1-Methylimidazoleacetic acid;N-Methylimidazole-4-acetic acid;N-Methylimidazoleacetic acid;NSC 66355;
• PSA 55.12000
• LogP 0.04720

Synthetic route

<1-methyl-imidazolyl-(4)>-acetic acid nitrile

<1-methyl-imidazolyl-(4)>-acetic acid nitrile

2625-49-2

1-methyl-4-imidazoleacetic acid

Conditions

Conditions	Yield
With sodium hydroxide

2625-49-2

1-methyl-4-imidazoleacetic acid

2-Amino-5-(4-methyl-phenyl)-thiophene-3-carboxylic Acid Amide

C18H16N4OS

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In chloroform at 120℃; Microwave irradiation;	92%

4-cyano-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-yl-phenyl)-amide trifluoroacetic acid salt

2625-49-2

1-methyl-4-imidazoleacetic acid

4-cyano-1H-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-{1-[2-(1-methyl-1H-imidazol-4-yl)acetyl]piperidin-4-yl}phenyl)amide trifluoroacetic acid salt

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 10h;	66%

871235-34-6

4-(2,4-dichloro-benzyloxy)-2-piperazin-1-yl-pyrimidine

2625-49-2

1-methyl-4-imidazoleacetic acid

1-{4-[4-(2,4-dichloro-benzyloxy)-pyrimidin-2-yl]-piperazin-1-yl}-2-(1-methyl-1H-imidazol-4-yl)-ethanone

Conditions

Conditions	Yield
With 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide

2625-49-2

1-methyl-4-imidazoleacetic acid

79-37-8

oxalyl dichloride

(4-Ethynyl-2-phenylbenzoyl)methionine methyl ester

{4-[4-(1-Methylimidazol-4-yl)-3-keto-1-butynyl]-2-phenylbenzoyl}-methionine methyl ester

Conditions

Conditions	Yield
With triethylamine; copper(I) iodide In dichloromethane; N,N-dimethyl-formamide
With triethylamine; copper(I) iodide In dichioromethane; dichloromethane; N,N-dimethyl-formamide

...Expand

2625-49-2

1-methyl-4-imidazoleacetic acid

6918-93-0

4-amino-3-benzoyl-benzonitrile

1024606-40-3

C20H13ClN4

Conditions

Conditions	Yield
With trichlorophosphate at 105℃;

2625-49-2

1-methyl-4-imidazoleacetic acid

1222196-35-1

(S)-2-amino-3-benzyloxy-N-(4-phenoxyphenyl)propanamide

1221879-24-8

(S)-3-(benzyloxy)-2-(2-(1-methyl-1H-imidazol-4-yl)-acetamido)-N-(4-phenoxyphenyl)propanamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃;

(2S,2'S)-tert-butyl 2,2'-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(azanediyl)bis(oxomethylene)dipyrrolidine-1-carboxylate

2625-49-2

1-methyl-4-imidazoleacetic acid

C36H40N8O4

Conditions

Conditions	Yield
Stage #1: (2S,2'S)-tert-butyl 2,2'-N,N'-(4,4'-((E)-ethene-1,2-diyl)bis(4,1-phenylene))bis(azanediyl)bis(oxomethylene)dipyrrolidine-1-carboxylate With hydrogenchloride In 1,4-dioxane; methanol at 0 - 20℃; Stage #2: 1-methyl-4-imidazoleacetic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;

2625-49-2

1-methyl-4-imidazoleacetic acid

60-33-3

linoleic acid

491-19-0, 3169-91-3, 3169-92-4, 3999-31-3, 39798-06-6, 39999-42-3, 41935-96-0, 41936-38-3, 51607-76-2, 51607-78-4, 53448-53-6, 58716-62-4, 106248-68-4, 106707-70-4, 120442-63-9

(±)-1,4-anhydroxylitol

C47H76N2O7

Conditions

Conditions

Yield

Stage #1: 1-methyl-4-imidazoleacetic acid; (±)-1,4-anhydroxylitol With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere; Stage #2: linoleic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;

...Expand

Methylimidazoleacetic acid Specification