Methylmagnesium bromide supplier

Name
METHYLMAGNESIUM BROMIDE
EINECS 200-844-1
CAS No. 75-16-1
Article Data32
CAS DataBase
Density 1.035 g/mL at 25 °C
Solubility vigorous reaction with water
Melting Point 0oC
Formula CH₃BrMg
Boiling Point 78-80 oC
Molecular Weight 119.244
Flash Point -20 oC
Transport Information UN 3399 4.3/PG 1
Appearance Clear brown solution when properly stored
Safety 9-16-26-45-61-36/37/39-62-43-36/37-23
Risk Codes 12-14-19-22-34-66-67-52/53-10-65-63-48/20-14/15-11
Molecular Structure
Hazard Symbols F,C
Synonyms Methylmagnesiumbromide (6CI);Bromomethylmagnesium;
PSA 0.00000
LogP 1.42940

Synthetic route

: 74-95-3
1,2-dibromomethane

A: 187737-37-7
propene

B: 74-85-1
ethene

C: 75-16-1
methylmagnesium bromide

D: 27329-47-1
methylenedimagnesium dibromide

E MgBr2: MgBr2

Conditions

Conditions	Yield
With amalgamated magnesium In diethyl ether; benzene at 0℃; special sealed glass apparatus; Further byproducts given;	A n/a B n/a C n/a D 50% E n/a

...Expand

: 74-83-9
methyl bromide

: 75-16-1
methylmagnesium bromide

Conditions

Conditions	Yield
With magnesium In diethyl ether Thermodynamic data; -ΔH(reaction);
With magnesium at -258.2℃; Product distribution; codeposition with other metals under matrix isolation conditions;
With magnesium In diethyl ether

: 1493-13-6
trifluorormethanesulfonic acid

: E-β-(dibenzylchlorosilyl)styrene

A: 75-16-1
methylmagnesium bromide

B: C15H14ClF3O3SSi

Conditions

Conditions	Yield
In dichloromethane

...Expand

: 1493-13-6
trifluorormethanesulfonic acid

: E-β-(benzyldiphenylsilyl)styrene

A: 75-16-1
methylmagnesium bromide

B: C20H17F3O3SSi

Conditions

Conditions	Yield
In dichloromethane

...Expand

: 74-83-9
methyl bromide

magnesium: magnesium

: 75-16-1
methylmagnesium bromide

Conditions

Conditions	Yield
With diethyl ether

: 87-41-2
2-benzofuran-1(3H)-one

: 75-16-1
methylmagnesium bromide

: 55549-01-4
α,α-dimethyl-o-xylene α,α'-diol

Conditions

Conditions	Yield
at -78 - 20℃;	100%
In tetrahydrofuran; diethyl ether at 30℃; for 12.5h;	88%
unter Wasserabgabe entsteht 1.1-Dimethyl-phthalan;

: 75-16-1
methylmagnesium bromide

: 15174-47-7
α-methyl-trans-cinnamaldehyde

: 87422-10-4
(E)-3-methyl-4-phenyl-but-3-en-2-ol

Conditions

Conditions	Yield
Stage #1: methylmagnesium bromide; α-methyl-trans-cinnamaldehyde In tetrahydrofuran; diethyl ether at 0℃; for 0.5h; Inert atmosphere; Stage #2: With water; ammonium chloride In tetrahydrofuran; diethyl ether	100%
With diethyl ether

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 75-16-1
methylmagnesium bromide

: 60514-82-1
2-(4-iodophenyl)propan-2-ol

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 72h;	100%

: 22725-38-8
3-methoxy-5H-dibenzo[a,d]cyclohepten-5-one

: 75-16-1
methylmagnesium bromide

: 125025-18-5
3-methoxy-5-methyl-5H-dibenzocyclohepten-5-ol

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether for 6h; Ambient temperature;	100%

: 112-45-8
10-Undecenal

: 75-16-1
methylmagnesium bromide

: 21951-49-5
dodec-11-en-2-ol

Conditions

Conditions	Yield
In diethyl ether at -40℃; Grignard reaction;	100%
In tetrahydrofuran at 0℃; Grignard reaction;	90%
In tetrahydrofuran; diethyl ether at -40 - 25℃; for 15h; Inert atmosphere;	83%

: 75-16-1
methylmagnesium bromide

: 82495-72-5
(E)-5-(N-benzyl-p-toluenesulfonamido)-3-methyl-6-phenylhex-3-on-2-one

: 82536-02-5
(E)-5-(N-benzyl-p-toluenefulfonamido)-2,3-dimethyl-6-phenylhex-3-en-2-ol

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether for 1h; -78 deg C -> 0 deg C;	100%

: 75-16-1
methylmagnesium bromide

: 93559-82-1
3-fluoro-5H-dibenzocyclohepten-5-one

: 125025-39-0
3-fluoro-5-methyl-5H-dibenzocyclohepten-5-ol

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether for 6h; Ambient temperature;	100%

: 75-16-1
methylmagnesium bromide

: 124098-64-2
6-(benzyloxy)-2,4-dimethylfuro<2,3-b>pyridine-5-carboxaldehyde

: 124098-67-5
5-(1-hydroxyethyl)-6-(benzyloxy)-2,4-dimethylfuro<2,3-b>pyridine

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether at 0℃; for 0.25h;	100%

: 75-16-1
methylmagnesium bromide

: 80783-99-9, 124931-15-3, 113474-86-5
N-methoxy-N-methylcinnamamide

: 1896-62-4
(E)-benzalacetone

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃;	100%
In tetrahydrofuran; diethyl ether at 0 - 20℃; for 2h;	98%
Stage #1: N-methoxy-N-methylcinnamamide With methyl 4-bromocinnamate; triethylsilyl trifluoromethyl sulfonate; triethylphosphine In toluene at 110℃; for 5h; Inert atmosphere; Stage #2: methylmagnesium bromide In tetrahydrofuran; toluene at -78℃; Inert atmosphere; Stage #3: With tetrabutyl ammonium fluoride In tetrahydrofuran; toluene for 0.5h; Inert atmosphere;	83%

: 75-16-1
methylmagnesium bromide

: Benzoic acid (2S,3S)-2-formyl-1-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl ester

: Benzoic acid (2R,3S)-2-(1-hydroxy-ethyl)-1-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl ester

Conditions

Conditions	Yield
In tetrahydrofuran at -45℃;	100%

: 75-16-1
methylmagnesium bromide

: 134197-98-1
(E)-3-(furan-2-yl)-N-methoxy-N-methylprop-2-enamide

: 623-15-4
(E)-4-(furan-2-yl)but-3-en-2-one

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃;	100%

: 75-16-1
methylmagnesium bromide

: 134197-97-0
(E)-N-methoxy-N-methyl-3-(thiophen-2-yl)acrylamide

: 874-83-9, 33603-63-3
(E)-4-(2-thienyl)but-3-en-2-one

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃;	100%

: 75-16-1
methylmagnesium bromide

: 134197-91-4
(1S,3R)-2,2-Dimethyl-3-phenyl-cyclopropanecarboxylic acid methoxy-methyl-amide

: 134197-90-3
[(1RS,3SR)-2,2-dimethyl-3-phenylcyclopropyl]ethanone

Conditions

Conditions	Yield
	100%

: 75-16-1
methylmagnesium bromide

: 134197-96-9
(E)-N-Methoxy-3-(6-methoxy-naphthalen-2-yl)-N-methyl-acrylamide

: 127053-22-9
4-(6'-methoxy-2'-naphthyl)-3-buten-2-one

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃;	100%

: 75-16-1
methylmagnesium bromide

: 134197-94-7
(E)-N-Methoxy-N-methyl-3-(3-phenoxy-phenyl)-acrylamide

: 121488-67-3
(E)-1-(3-Phenoxyphenyl)buten-3-one

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃;	100%

: 75-16-1
methylmagnesium bromide

: 134197-95-8
(E)-3-(4-(benzyloxy)phenyl)-N-methoxy-N-methylacrylamide

: 75676-91-4
1-(4-benzyloxyphenyl)but-1-en-3-one

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃;	100%

: 75-16-1
methylmagnesium bromide

: 134197-93-6
(E)-N-Methoxy-N-methyl-3-[4-(1-phenyl-ethoxy)-phenyl]-acrylamide

: 134197-92-5
(E)-4-[4-(1-Phenyl-ethoxy)-phenyl]-but-3-en-2-one

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃;	100%

: 75-16-1
methylmagnesium bromide

: 122421-16-3
2-<(trimethylsilyl)methyl>-2-butenal

: 141023-16-7
(Z)-3-((trimethylsilyl)methyl)pent-3-en-2-ol

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether for 0.333333h; Ambient temperature;	100%

: 75-16-1
methylmagnesium bromide

: 136964-79-9
C26H24O2S

: 79979-60-5
11-methyl-12-phenyl-9,10-dihydro-9,10-etheno-anthracene

Conditions

Conditions	Yield
palladium(II) acetylacetonate In tetrahydrofuran Heating;	100%

: 75-16-1
methylmagnesium bromide

: 134454-00-5
Methyl (1R,2S)-2-<2-(3-Isopropylphenyl)ethyl>-1-methyl-3-oxo-1-cyclohexanecarboxylate

: 134365-17-6
Methyl (1R,2S,3R)-1,3-Dimethyl-1-hydroxy-2<2-(3-isopropylphenyl)-ethyl>cyclohexanecarboxylate

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 2h;	100%

: 75-16-1
methylmagnesium bromide

: 141807-44-5, 126613-06-7, 128544-05-8, 128575-34-8
(+/-)-2,2'-bis(trifluoromethanesulfonyloxy)-1,1-binaphthyl

: 60536-98-3, 19634-89-0, 32587-64-7, 32834-84-7
2,2'-dimethyl-1,1'-binaphthyl

Conditions

Conditions	Yield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In diethyl ether at 0℃; for 24h; Reflux;	100%
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In diethyl ether at 20℃;	99%
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In diethyl ether at 20℃; for 1h; Substitution;	99%

: 75-16-1
methylmagnesium bromide

: 154811-20-8
8-oxabicyclo<3.2.1>oct-6-en-2-one

: (1R,2R,5R)-2-Methyl-8-oxa-bicyclo[3.2.1]oct-6-en-2-ol

Conditions

Conditions	Yield
In diethyl ether at 0℃;	100%
In diethyl ether at 0℃;

: 1121-60-4
pyridine-2-carbaldehyde

: 75-16-1
methylmagnesium bromide

: 20988-55-0, 18728-61-5, 27911-63-3, 59042-90-9
1-(pyridine-2-yl)ethanol

Conditions

Conditions	Yield
In diethyl ether at 0℃; for 2h;	100%
In diethyl ether at 0 - 5℃; for 2h; Inert atmosphere;	61%
Yield given;

: 75-16-1
methylmagnesium bromide

: 161659-30-9
(3aS,5R,5aR,6aS,9aS,9bS,9cS)-5-Methoxy-1,1,8,8,9c-pentamethyl-decahydro-4,7,9-trioxa-cyclopenta[e]acenaphthylen-6-one

: 161659-31-0
1,2,3,3aβ,5aβ,6,6aα,9aα,9bα,9c-decahydro-6α-hydroxy-5β-methoxy-1,1,6β,8,8,9cβ-hexamethyl-5H-furo<4',3',2':4,5>naphtho<1,2-d><1,3>dioxolane

Conditions

Conditions	Yield
In diethyl ether for 1h; Ambient temperature;	100%

: 75-16-1
methylmagnesium bromide

: 157396-11-7
7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one

: 146564-05-8
1-Benzenesulfonyl-7-(4-chloro-phenylsulfanyl)-4-methyl-4,5,6,7-tetrahydro-1H-indol-4-ol

Conditions

Conditions	Yield
In tetrahydrofuran for 4h; Ambient temperature;	100%

: 75-16-1
methylmagnesium bromide

: 161227-56-1
Bis-(1-triisopropylsilanyl-1H-pyrrol-3-yl)-methanone

: 161227-57-2
C28H50N2Si2

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether for 2h; Ambient temperature;	100%

: 75-16-1
methylmagnesium bromide

: 2-Benzyl-6-methyl-1-phenyl-3,4-dihydro-isoquinolinium; iodide

: 174784-47-5
2-benzyl-1,6-dimethyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
In tetrahydrofuran for 1h; Ambient temperature;	100%

: 75-16-1
methylmagnesium bromide

: 2-Benzyl-1-cyclohexyl-3,4-dihydro-isoquinolinium; bromide

: 126115-25-1
2-benzyl-1-cyclohexyl-1-methyl-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
In tetrahydrofuran for 1h; Ambient temperature;	100%

: 75-16-1
methylmagnesium bromide

: (1S,2R,5S)-2-Benzyloxy-1,5-dimethyl-8-oxa-bicyclo[3.2.1]octan-6-one

: (1R,2S,5R,6R)-2-Benzyloxy-1,5,6-trimethyl-8-oxa-bicyclo[3.2.1]octan-6-ol

Conditions

Conditions	Yield
In diethyl ether	100%

: 75-16-1
methylmagnesium bromide

: 91103-47-8
N-(tert-butoxycarbonyl)-D-alanine methyl ester

: 186466-64-8
((R)-2-hydroxy-1,2-dimethyl-propyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: methylmagnesium bromide; N-(tert-butoxycarbonyl)-D-alanine methyl ester In tetrahydrofuran at 0 - 20℃; for 16h; Stage #2: With water In tetrahydrofuran Cooling with ice;	100%
Stage #1: methylmagnesium bromide; N-(tert-butoxycarbonyl)-D-alanine methyl ester In tetrahydrofuran at 0 - 20℃; for 3h; Stage #2: With water; ammonium chloride In tetrahydrofuran	99%
In tetrahydrofuran; diethyl ether at 0 - 25℃; for 2h;	99%

Methylmagnesium bromide Chemical Properties

MF: CH₃BrMg
MW: 119.24
density 1.035 g/mL at 25 °C
Fp 77 °F
storage temp. water-free area
Sensitive Air & Moisture Sensitive

Methylmagnesium bromide Toxicity Data With Reference

RTECS OM3700000

Methylmagnesium bromide Consensus Reports

Reported in EPA TSCA Inventory.

Methylmagnesium bromide Safety Profile

May ignite spontaneously in air. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. See also ETHERS, MAGNESIUM COMPOUNDS, and BROMIDES.

Methylmagnesium bromide Standards and Recommendations

DOT Classification: 4.3; Label: Dangerous When Wet, Flammable Liquid

Product Name

METHYLMAGNESIUM BROMIDE

Synthetic route

Methylmagnesium bromide Chemical Properties

Methylmagnesium bromide Toxicity Data With Reference

Methylmagnesium bromide Consensus Reports

Methylmagnesium bromide Safety Profile

Methylmagnesium bromide Standards and Recommendations

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