N-Acetyl-L-aspartic acid supplier

Name
N-Acetyl-L-aspartic acid
EINECS 213-643-9
CAS No. 997-55-7
Article Data12
CAS DataBase
Density 1.422 g/cm³
Solubility
Melting Point 137-140 °C(lit.)
Formula C₆H₉NO₅
Boiling Point 425.3 °C at 760 mmHg
Molecular Weight 175.141
Flash Point 211 °C
Transport Information
Appearance White powder
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Asparticacid, N-acetyl-, L- (8CI);Acetyl-L-aspartic acid;Acetylaspartic acid;L-N-Acetylaspartic acid;N-Acetyl-S-aspartic acid;N-Acetylaspartic acid;
PSA 103.70000
LogP -0.55870

Synthetic route

: 56-84-8
L-Aspartic acid

: 108-24-7
acetic anhydride

: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
In water for 0.0666667h; Irradiation;	99%

: 41148-79-2
(S)-N-acetyl-L-aspartic anhydride

: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
With water

: 5269-42-1
L-Aspartic acid bis(trimethylsilyl) ester

: 75-36-5
acetyl chloride

: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
Stage #1: L-Aspartic acid bis(trimethylsilyl) ester; acetyl chloride With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In dichloromethane at 20℃; Stage #2: With methanol In dichloromethane at 20℃;

: 19146-51-1
(S)-N-Acetylaminobutyric acid

: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
With hydrogen peroxide; trifluoroacetic acid In water-d2 Kinetics; Photolysis;

: 3106-85-2
N-acetyl-L-aspartyl-L-glutamate

A: 56-86-0
L-glutamic acid

B: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
With glutamate carboxypeptidase II; TACN*Zn(II) complex; 2-hydroxypropyl-p-nitrophenyl phosphate at 40℃; pH=7; Kinetics; aq. buffer; Enzymatic reaction;

: 56-84-8
L-Aspartic acid

: 17336-14-0
2-acetyloxy-5-nitrobenzoic acid

: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
In water at 25℃; Kinetics; Concentration;

: 56-84-8
L-Aspartic acid

: 1734-62-9
2-acetoxy-5-chloro-benzoic acid

: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
In water at 25℃; Kinetics; Concentration;

: 56-84-8
L-Aspartic acid

: 50-78-2
aspirin

: 997-55-7
N-Acetyl-L-aspartic acid

Conditions

Conditions	Yield
In water at 25℃; Kinetics; Concentration;

: 997-55-7
N-Acetyl-L-aspartic acid

: 41148-79-2
(S)-N-acetyl-L-aspartic anhydride

Conditions

Conditions	Yield
With acetic anhydride at 20 - 80℃; for 5h;	88%

: 997-55-7
N-Acetyl-L-aspartic acid

: 3-amino-7-methyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one dihydrochloride

: 1357057-62-5
N-acetyl-L-aspartic acid (3S)-3-amino-7-methyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one salt

Conditions

Conditions	Yield
Stage #1: 3-amino-7-methyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one dihydrochloride With sodium hydroxide In dichloromethane at 20℃; for 0.5h; Stage #2: N-Acetyl-L-aspartic acid In ethanol at 60℃; for 1h;	83%

: 50-00-0
formaldehyd

: 997-55-7
N-Acetyl-L-aspartic acid

: 1316250-66-4
(S)-3-acetyl-5-oxo-4-oxazolidineacetic acid

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 80℃; for 0.25h; Microwave irradiation;	75%

: 997-55-7
N-Acetyl-L-aspartic acid

: 23541-50-6
daunomycin hydrochloride

: 3'-N-[(N-acetyl)-β-aspartyl]-daunomycin

Conditions

Conditions	Yield
With 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 4h;	74%

: 997-55-7
N-Acetyl-L-aspartic acid

: 56-81-5
glycerol

A: 388587-59-5
rac-1-O-(Nα-acetyl-L-aspartyl-1-yl)glycerol

B: rac-2-O-(Nα-Ac-L-aspart-1-yl)glycerol

Conditions

Conditions	Yield
With Novozym 435 In various solvent(s) at 50℃; for 24h;	A 73% B n/a

...Expand

: 997-55-7
N-Acetyl-L-aspartic acid

: 25316-40-9
doxorubicin hydrochloride

: 3'-N-[(N-acetyl)-β-aspartyl]-doxorubicin

Conditions

Conditions	Yield
With 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 5h;	71%

: 997-55-7
N-Acetyl-L-aspartic acid

: 25316-40-9
doxorubicin hydrochloride

: 3'-N,14-bis[(N-acetyl)-β-aspartyl]-doxorubicin

Conditions

Conditions	Yield
With 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 10h;	67%

: 997-55-7
N-Acetyl-L-aspartic acid

: 29742-67-4
14-bromodaunorubicin hydrochloride

: daunomycin-14-(N-acetyl)-β-aspartate hydrochloride

Conditions

Conditions	Yield
With triethylamine In acetone at 20℃; for 8h;	61%

: 997-55-7
N-Acetyl-L-aspartic acid

: 43200-80-2
zopiclon

A: 1107971-11-8
(R)-zopiclone N-acetyl-L-aspartate

B: 1107971-15-2
(S)-zopiclone N-acetyl-L-aspartate

Conditions

Conditions	Yield
In methanol; toluene at 20℃; for 1.21667h; Product distribution / selectivity; Heating / reflux;	A 46% B 43%
In methanol; toluene at 20℃; for 1.21667h; Product distribution / selectivity; Heating / reflux;	A 46% B 43%

...Expand

: 997-55-7
N-Acetyl-L-aspartic acid

: 1044870-39-4
2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one

: 4-(2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]butyl)-4-oxo-2-acetaminobutyric acid

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetone at 0 - 20℃; for 24h;	45%

: 997-55-7
N-Acetyl-L-aspartic acid

: 43200-80-2
zopiclon

: 1107971-11-8
(R)-zopiclone N-acetyl-L-aspartate

Conditions

Conditions	Yield
In methanol; xylene at 20℃; for 1.16667h; Product distribution / selectivity; Heating / reflux;	41%
In methanol; xylene at 20℃; for 1.16667h; Product distribution / selectivity; Heating / reflux;	41%

: 997-55-7
N-Acetyl-L-aspartic acid

: C16H22F3NO4

: C38H49F6N3O11

Conditions

Conditions	Yield
Stage #1: N-Acetyl-L-aspartic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Stage #2: C16H22F3NO4 In dichloromethane at 20℃; for 2h;	38%

: 997-55-7
N-Acetyl-L-aspartic acid

: 141473-49-6
tetraethyl 3-aminopropylidene-1,1-bisphosphonate

: [3-{2-acetylamino-3-[3,3-bis-(diethoxy-phosphoryl)-propylcarbamoyl]-propionylamino}-1-(diethoxy-phosphoryl)-propyl]-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 20℃;

: 997-55-7
N-Acetyl-L-aspartic acid

: {3-[2-acetylamino-3-(3,3-bis-phosphono-propylcarbamoyl)-propionylamino]-1-phosphono-propyl}-phosphonic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: BOP; triethylamine / CH2Cl2 / 20 °C 2: TMSBr / CH2Cl2 / 20 °C View Scheme

: 997-55-7
N-Acetyl-L-aspartic acid

: cis-(+/-)-2-phenylpiperidin-3-ylamine

: C23H30N4O8

Conditions

Conditions	Yield
In methanol at 20 - 50℃; for 2.16667h;	n/a

: 997-55-7
N-Acetyl-L-aspartic acid

: 56-35-9
bis(tri-n-butyltin)oxide

: N-acetyl-L-OCOCH2CHNHCOO-bis(tri-n-butyltin)

Conditions

Conditions	Yield
In toluene byproducts: H2O; azeotropic dehydration with toluene; recrystn. (benzene) or sublimation;

: copper(II) acetate hydrate

: 997-55-7
N-Acetyl-L-aspartic acid

: (Cu(OOCCH(NHCOCH3)CH2COO)(H2O))2*2H2O

Conditions

Conditions	Yield
In water reaction of Cu(ac)2 with N-acetyl-L-aspartic acid in water; concn. of the soln. at 50°C, elem. anal.;

: 997-55-7
N-Acetyl-L-aspartic acid

: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With recombinant Streptomyces mobaraensis aminoacylase; water at 37℃; pH=7.5; aq. buffer; Enzymatic reaction;
With E. coli BL21 Star (DE3) S30 extract In aq. buffer at 37℃; for 6h; pH=7.5;

: 997-55-7
N-Acetyl-L-aspartic acid

: C12H17NO7

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene / 0.25 h / 80 °C / Microwave irradiation 2: 4-methyl-morpholine / tetrahydrofuran / -15 °C / Inert atmosphere View Scheme

: 997-55-7
N-Acetyl-L-aspartic acid

: C7H11NO4

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / toluene / 0.25 h / 80 °C / Microwave irradiation 2: 4-methyl-morpholine / tetrahydrofuran / -15 °C / Inert atmosphere 3: sodium tetrahydroborate / tetrahydrofuran View Scheme

N-Acetyl-L-aspartic acid Chemical Properties

Molecular Structure:

Molecular Formula: C₆H₉NO₅
Molecular Weight: 175.1394
IUPAC Name: (2S)-2-Acetamidobutanedioate
Synonyms of N-Acetyl-L-aspartic acid (CAS NO.997-55-7): N-Acetylaspartate ; 4-04-00-03015 (Beilstein Handbook Reference) ; Acetyl-L-aspartic acid ; Acetylaspartic acid ; BRN 1726198 ; EINECS 213-643-9 ; L-N-Acetylaspartic acid ; N-Acetylaspartic acid ; NSC 128610 ; Aspartic acid, N-acetyl-, L- (8CI) ; L-Aspartic acid, N-acetyl-
CAS NO: 997-55-7
Classification Code: Drug / Therapeutic Agent
Melting point: 137-140 °C
Index of Refraction: 1.505
Molar Refractivity: 36.55 cm³
Molar Volume: 123.1 cm³
Surface Tension: 61.5 dyne/cm
Density: 1.422 g/cm³
Flash Point: 211 °C
Enthalpy of Vaporization: 74.57 kJ/mol
Boiling Point: 425.3 °C at 760 mmHg
Vapour Pressure of N-Acetyl-L-aspartic acid (CAS NO.997-55-7): 2E-08 mmHg at 25°C

N-Acetyl-L-aspartic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	2660mg/kg (2660mg/kg)		Pharmaceutical Chemistry Journal Vol. 25, Pg. 569, 1991.

N-Acetyl-L-aspartic acid Safety Profile

Safety Statements of N-Acetyl-L-aspartic acid (CAS NO.997-55-7): 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: CI9098600

Product Name

N-Acetyl-L-aspartic acid

Synthetic route

N-Acetyl-L-aspartic acid Chemical Properties

N-Acetyl-L-aspartic acid Toxicity Data With Reference

N-Acetyl-L-aspartic acid Safety Profile

Related Products

Hot Products