N-Benzyl-N-phenylhydrazine hydrochloride supplier

Name
1-BENZYL-1-PHENYLHYDRAZINE HYDROCHLORIDE
EINECS 227-195-7
CAS No. 5705-15-7
Density 1.13 g/cm³
Solubility
Melting Point 178-181°C
Formula C₁₃H₁₄N₂^.HCl
Boiling Point 346.6 °C at 760 mmHg
Molecular Weight 234.728
Flash Point 186.3 °C
Transport Information
Appearance
Safety 26-36/37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols R36/37/38:Irritating to eyes, respiratory system and skin.;
Synonyms Hydrazine,1-benzyl-1-phenyl-, hydrochloride (6CI,7CI);Hydrazine, 1-benzyl-1-phenyl-,monohydrochloride (8CI);Hydrazine, 1-phenyl-1-(phenylmethyl)-,monohydrochloride (9CI);1-Benzyl-1-phenylhydrazine hydrochloride;N-Benzyl-N-phenylhydrazine hydrochloride;N-Phenyl-N-benzylhydrazinehydrochloride;a-Benzyl-a-phenylhydrazine hydrochloride;1-Benzyl-1-phenylhydrazine HCl;
PSA 29.26000
LogP 4.06920

Synthetic route

: C13H17NO2

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: C26H26N2O

Conditions

Conditions	Yield
With pyridine; pyridine hydrochloride at 100℃; for 23h; Inert atmosphere;	98%

: 1254982-53-0
C14H17NO2

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 1254982-27-8
5-(1-benzyl-1H-indol-3-yl)-2-(benzyloxy)pentanenitrile

Conditions

Conditions	Yield
With acetic acid at 100℃; for 1h; Fischer indole synthesis; Inert atmosphere;	89%

: 65755-81-9
1-phenyl-2-(2-propenyloxy)ethanone

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: C24H21NO

Conditions

Conditions	Yield
With L-Tartaric acid at 70℃; for 4h;	87%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 89587-12-2
α-dimethylaminomethylene-N-phenyl-γ-butyrolactam

A: 89587-10-0
2,3,4,9-Tetrahydro-2-phenyl-1H-pyrido<3,4-b>indol-1-one

B: 89587-08-6
9-benzyl-2-phenyl-1-oxo-1,2,3,4-tetrahydro-β-carboline

Conditions

Conditions	Yield
In hydrogenchloride; isopropyl alcohol for 3h; Heating;	A 3% B 86%

...Expand

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 89587-11-1
α-dimethylaminomethylene-γ-butyrolactam

A: 17952-82-8
1,2,3,4-tetrahydronorharman-1-one

B: 34034-29-2
9-benzyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-one

Conditions

Conditions	Yield
With hydrogenchloride In isopropyl alcohol for 3h; Heating;	A 5% B 82%

...Expand

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 59157-01-6
3-<(N,N-dimethylamino)methylene>-1-methyl-2-pyrrolidinone

A: 59156-98-8
Strychnocarpine

B: 59156-99-9
2,3,4,9-Tetrahydro-2-methyl-9-(phenylmethyl)-1H-pyrido<3,4-b>indol-1-one

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol for 3h; Heating;	A n/a B 80%

...Expand

: 13042-80-3
3,4-dihydro-2H-thiopyran

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 128083-15-8
1-(2-tetrahydrothiopyranylthio)-3-(1-benzyl-3-indolyl)propane

Conditions

Conditions	Yield
With water In 1,4-dioxane for 4h; Heating;	79%

: 53526-25-3
hexyl 6-methoxy-2-naphthyl ketone

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 481631-58-7
1-benzyl-2-(6-methoxynaphthalen-2-yl)-3-pentyl-1H-indole

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 70 - 80℃; for 7h; Fischer Indole Synthesis; Heating / reflux;	78%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 180403-47-8
3-[1-Dimethylamino-meth-(Z)-ylidene]-dihydro-thiophen-2-one

: 9-Benzyl-4,9-dihydro-3H-thiopyrano[3,4-b]indol-1-one

Conditions

Conditions	Yield
With trifluoroacetic acid In 1,4-dioxane for 8h; Heating;	77%

: 6461-87-6
2-formyltetramethylene Sulfone

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 2-formyltetramethylene sulfone 1-benzyl-1-phenylhydrazone

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol for 3h; Reflux;	76%
With hydrogenchloride In water; isopropyl alcohol for 3h; Reflux;	76%

: 2386-26-7
ethyl 4-acetyl-3,5-dimethylpyrrole-2-carboxylate

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 87650-54-2
2,4-dimethyl-3-acetyl-5-ethoxycarbonylpyrrole N-benzyl-N-phenylhydrazone hydrochloride

Conditions

Conditions	Yield
In ethanol for 5h; Heating;	75%

: 3986-95-6
diethyl (3-oxopropyl)phosphonate

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 119592-33-5
(1-Benzyl-1H-indol-3-ylmethyl)-phosphonic acid diethyl ester

Conditions

Conditions	Yield
In ethanol Heating;	72%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 72740-33-1
α,α'-hydroxybis(1-methyl-3-methylene-2-piperidone)

: 122510-78-5
10-benzyl-2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one

Conditions

Conditions	Yield
With sulfuric acid In ethanol; water for 4h; Heating;	70%

: 58486-00-3
1-benzylpyrrolidine-2,3-dione

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 2-dibenzyl-1,4-dihydropyrrolo[3,4-b]indol-3(2H)-one

Conditions

Conditions	Yield
Stage #1: 1-benzylpyrrolidine-2,3-dione; N-benzyl-N-phenylhydrazine hydrochloride With acetic acid at 80℃; for 0.333333h; Stage #2: With hydrogenchloride In water at 80℃; for 2.5h;	66%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 59157-00-5
1-Methyl-3-formyl-2-pyrrolidone

: 59156-99-9
2,3,4,9-Tetrahydro-2-methyl-9-(phenylmethyl)-1H-pyrido<3,4-b>indol-1-one

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol for 3h; Heating;	62%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 39654-67-6
N-methyl-α-dimethylaminomethylenesuccinimide

A: 111725-63-4
2-Methyl-4,9-dihydro-β-carboline-1,3-dione

B: 111725-61-2
9-Benzyl-2-methyl-4,9-dihydro-β-carboline-1,3-dione

Conditions

Conditions	Yield
With hydrogenchloride In acetic acid for 3h; Heating;	A 13% B 61%

...Expand

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 111725-60-1
N-methyl-α-dimethylaminomethyleneglutarimide

A: 111725-67-8
2-methyl-1,3-dioxo-1,2,3,4,5,10-hexahydroazepino<3,4-b>indole

B: 111725-64-5
2-methyl-10-benzyl-1,3-dioxo-1,2,3,4,5,10-hexahydroazepino<3,4-b>indole

Conditions

Conditions	Yield
With hydrogenchloride In acetic acid for 3h; Heating;	A 7% B 61%

...Expand

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 63352-50-1
α-dimethylaminomethylene-N-butyl-γ-butyrolactam

A: 74300-22-4
9-Benzyl-2-butyl-2,3,4,9-tetrahydro-β-carbolin-1-one

B: 74300-21-3
2-n-butyl-1-oxo-1,2,3,4-tetrahydro-β-carboline

Conditions

Conditions	Yield
With hydrogenchloride In methanol; isopropyl alcohol for 3h; Heating;	A 60% B n/a

...Expand

: 931-20-4
1-methylpiperidin-2-one

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 122510-78-5
10-benzyl-2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one

Conditions

Conditions	Yield
Stage #1: 1-methylpiperidin-2-one; N,N-dimethyl-formamide With trichlorophosphate In benzene for 5.5h; Vilsmeier Reaction; Reflux; Stage #2: N-benzyl-N-phenylhydrazine hydrochloride In ethanol for 2h; Reflux;	60%
Stage #1: 1-methylpiperidin-2-one; N,N-dimethyl-formamide With trichlorophosphate In benzene for 5.5h; Vilsmeier Reaction; Reflux; Stage #2: N-benzyl-N-phenylhydrazine hydrochloride In ethanol for 2h; Reflux;	60%

...Expand

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 52649-04-4
Ethyl β-(2,4-dimethyl-5-carboethoxypyrrolyl-3)-β-ketopropionate

: 87650-54-2
2,4-dimethyl-3-acetyl-5-ethoxycarbonylpyrrole N-benzyl-N-phenylhydrazone hydrochloride

Conditions

Conditions	Yield
In ethanol for 11h; Heating; than standing for 2 days;	59%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 1885-14-9
phenyl chloroformate

: phenyl 2-benzyl-2-phenylhydrazine-1-carboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃; for 2h;	59%

: 66003-76-7
Diphenyliodonium triflate

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 102174-16-3
N′-benzyl-N′-phenylbenzenesulfonohydrazide

Conditions

Conditions	Yield
With potassium pyrosulfite; C34H30N2O4 In dimethyl sulfoxide; acetonitrile at 20℃; for 2h; Inert atmosphere; Schlenk technique; Irradiation;	59%

: 89910-21-4
α-hydroxymethylene-N-methyl-δ-valerolactam

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

A: 122510-78-5
10-benzyl-2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one

B: 30264-08-5
2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one

Conditions

Conditions	Yield
With sulfuric acid In ethanol; water for 4h; Heating;	A 57% B 8%

...Expand

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 1431570-01-2
methyl 1-benzyl-2-(2-methoxy-2-oxoethyl)-1H-indole-3-carboxylate

Conditions

Conditions	Yield
In methanol Fischer Indole Synthesis; Heating;	57%
In methanol for 12h; Fischer Indole Synthesis; Heating;	57%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 57982-40-8
1-benzyl-2-ethoxycarbonylmethyl-indole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In ethanol Fischer Indole Synthesis; Reflux;	54%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 70499-16-0
4a′-methyl-4′,4a′,7′,8′-tetrahydro-3′H-spiro[[1,3]dithiolane-2,2′-naphthalen]-5′(6′H)-one

: 11-benzyl-11b-methyl-1,2,5,6,11,11b-hexahydrospiro[benzo[a]carbazole-3,2'-[1,3]dithiolane]

Conditions

Conditions	Yield
With acetic acid at 100℃; for 2h; Inert atmosphere;	53%

: 1193-47-1
2,2-dimethyl-cyclohexanone

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 9-benzyl-1,1-dimethyl-1,2,3,4-tetrahydrocarbazole

Conditions

Conditions	Yield
In acetic acid for 1h; Fiacher indole synthesis; Heating;	52%

: (3aR,6aS)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: C20H22N2

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 130℃; for 0.5h; Fischer Indole Synthesis; Microwave irradiation;	51%

: 13042-80-3
3,4-dihydro-2H-thiopyran

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 128083-16-9
5-(2-tetrahydrothiopyranylthio)pentanal α-benzylphenylhydrazone

Conditions

Conditions	Yield
In 1,4-dioxane; water for 24h; Ambient temperature;	50%

: 5705-15-7
N-benzyl-N-phenylhydrazine hydrochloride

: 72740-35-3
3-[1-Dimethylamino-meth-(Z)-ylidene]-1-methyl-azepan-2-one

A: 122531-38-8
2-methyl-2,3,4,5,6,11-hexahydro-1H-azocino<3,4-b>indol-1-one

B: 122531-39-9
2-methyl-11-benzyl-2,3,4,5,6,11-hexahydro-1H-azocino<3,4-b>indol-1-one

Conditions

Conditions	Yield
With sulfuric acid In ethanol; water for 4h; Heating;	A 17% B 45%

...Expand

N-Benzyl-N-phenylhydrazine hydrochloride Specification

The N-Benzyl-N-phenylhydrazine hydrochloride, with the CAS registry number 5705-15-7 and EINECS registry number 227-195-7, has the systematic name of 1-benzyl-1-phenylhydrazine hydrochloride (1:1). And the molecular formula of the chemical is C₁₃H₁₄N₂^.HCl.

The characteristics of N-Benzyl-N-phenylhydrazine hydrochloride are as followings: (1)ACD/LogP: 2.63; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.4; (4)ACD/LogD (pH 7.4): 2.63; (5)ACD/BCF (pH 5.5): 34.44; (6)ACD/BCF (pH 7.4): 58.44; (7)ACD/KOC (pH 5.5): 376.3; (8)ACD/KOC (pH 7.4): 638.41; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 6.48 Å²; (13)Flash Point: 186.3 °C; (14)Enthalpy of Vaporization: 59.08 kJ/mol; (15)Boiling Point: 346.6 °C at 760 mmHg; (16)Vapour Pressure: 5.7E-05 mmHg at 25°C.

Uses of N-Benzyl-N-phenylhydrazine hydrochloride: It can be used to produce 1-(2-tetrahydrothiopyranylthio)-3-(1-benzyl-3-indolyl)propane. This reaction will need reagent H₂O, and the menstruum dioxane. The reaction time is 4 hours with heating, and the yield is about 79%.

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: Cl.NN(c1ccccc1)Cc2ccccc2
(2)InChI: InChI=1/C13H14N2.ClH/c14-15(13-9-5-2-6-10-13)11-12-7-3-1-4-8-12;/h1-10H,11,14H2;1H
(3)InChIKey: JTYLHYOCBGPMNO-UHFFFAOYAE

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	300mg/kg (300mg/kg)	National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	106mg/kg (106mg/kg)	Acta Biologica et Medica Germanica. Vol. 17, Pg. 614, 1966.
rat	LD50	intraperitoneal	404mg/kg (404mg/kg)	Acta Biologica et Medica Germanica. Vol. 18, Pg. 617, 1967.

Product Name

1-BENZYL-1-PHENYLHYDRAZINE HYDROCHLORIDE

Synthetic route

N-Benzyl-N-phenylhydrazine hydrochloride Specification

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