N-Methyl-3,3-diphenylpropylamine supplier

Name
N-Methyl-3,3-diphenylpropylamine
EINECS 248-821-5
CAS No. 28075-29-8
Article Data10
CAS DataBase
Density 0.989 g/cm³
Solubility
Melting Point
Formula C₁₆H₁₉N
Boiling Point 347.374 °C at 760 mmHg
Molecular Weight 225.334
Flash Point 164.5 °C
Transport Information
Appearance the white crystals
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Propylamine,N-methyl-3,3-diphenyl- (8CI);(3,3-Diphenylpropyl)methylamine;N-Methyl-3,3-diphenylpropylamine;
PSA 12.03000
LogP 3.81890

Synthetic route

: 42142-52-9
3-methylamino-1-phenylpropan-1-ol

: 71-43-2
benzene

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid	83%

: 348607-76-1
3,3-diphenylpropanoic acid N-methylamide

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 4h;	66%

: N-benzyl-N-methyl-3,3-diphenylpropylamine

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
With hydrogenchloride; aq. NaOH In methanol

: 103-67-3
benzyl-methyl-amine

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 621-82-9
Cinnamic acid

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: thionyl chloride / Heating 2: 1,4-dioxane / 0.17 h / 20 °C 3: trifluorormethanesulfonic acid / 2 h / 20 °C 4: lithium aluminium tetrahydride / diethyl ether / 4 h View Scheme

: 102-92-1
cinnamoyl chloride

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1,4-dioxane / 0.17 h / 20 °C 2: trifluorormethanesulfonic acid / 2 h / 20 °C 3: lithium aluminium tetrahydride / diethyl ether / 4 h View Scheme

: 13565-07-6, 15851-89-5
4-methylcinnamoyl chloride

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1,4-dioxane / 0.17 h / 20 °C 2: trifluorormethanesulfonic acid / 1 h / 20 °C 3: lithium aluminium tetrahydride / diethyl ether / 4 h View Scheme

: C11H11ClO

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1,4-dioxane / 0.17 h / 20 °C 2: trifluorormethanesulfonic acid / 1 h / 20 °C 3: lithium aluminium tetrahydride / diethyl ether / 4 h View Scheme

: 1866-39-3
4-methylcinnamic acid

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: thionyl chloride / Heating 2: 1,4-dioxane / 0.17 h / 20 °C 3: trifluorormethanesulfonic acid / 1 h / 20 °C 4: lithium aluminium tetrahydride / diethyl ether / 4 h View Scheme

: 147219-20-3, 60521-25-7
3-(3,4-Dimethylphenyl)-propensaeure

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: thionyl chloride / Heating 2: 1,4-dioxane / 0.17 h / 20 °C 3: trifluorormethanesulfonic acid / 1 h / 20 °C 4: lithium aluminium tetrahydride / diethyl ether / 4 h View Scheme

: 2757-10-0
N-methylcinnamamide

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: trifluorormethanesulfonic acid / 2 h / 20 °C 2: lithium aluminium tetrahydride / diethyl ether / 4 h View Scheme

: 3-(4-methylphenyl)propenoic acid N-methylamide

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: trifluorormethanesulfonic acid / 1 h / 20 °C 2: lithium aluminium tetrahydride / diethyl ether / 4 h View Scheme

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 78-94-4
methyl vinyl ketone

: 100427-47-2
4-[N-(3,3-diphenylpropyl)-N-methylamino]-2-butanone

Conditions

Conditions	Yield
In diethyl ether at -5 - 3℃;	90%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 54851-30-8
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-chloroethyl ester 5-isopropyl ester

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-ethyl} ester 5-isopropyl ester

Conditions

Conditions	Yield
Heating;	85%

: 558-42-9
3-chloro-2-methylpropan-2-ol

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 100442-33-9
2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol

Conditions

Conditions	Yield
In xylene for 8.5h; Heating;	80%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 75-56-9, 16033-71-9
methyloxirane

: 100427-50-7
1-[N-(3,3-diphenylpropyl)-N-methylamino]-2-propanol

Conditions

Conditions	Yield
In methanol at 15 - 20℃; for 96h;	70%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 100427-03-0
2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-ethyl) ester 5-(2-propoxy-ethyl) ester

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-ethyl} ester 5-(2-propoxy-ethyl) ester

Conditions

Conditions	Yield
Heating;	59%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 54585-92-1
2-chloroethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-ethoxy-carbonyl-1,4-dihydropyridine-3-carboxylate

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-ethyl} ester 5-ethyl ester

Conditions

Conditions	Yield
Heating;	55%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 85175-59-3
3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one

: 7,8-dimethoxy-3-aminopropyl-1,3-dihydro-2H-3-benzazepin-2-one

Conditions

Conditions	Yield
In toluene for 10h; Heating;	50%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 91040-32-3
2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-ethyl) ester 5-isobutyl ester

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-ethyl} ester 5-isobutyl ester

Conditions

Conditions	Yield
Heating;	50%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 7693-46-1
4-Nitrophenyl chloroformate

: 4-nitrophenyl 3,3-diphenylpropyl(methyl)carbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h; Inert atmosphere;	49%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: (R)-1-(2-bromoethyl)-3-piperidinecarboxylic acid ethyl ester

: (R)-1-(2-(N-(3,3-diphenyl-1-propyl)-N-methylamino)ethyl)-3-piperidinecarboxylic acid ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 504000h; Condensation;	36%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-1-methyl-ethyl) ester 5-methyl ester

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-1-methyl-ethyl} ester 5-methyl ester

Conditions

Conditions	Yield
Heating;	35%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 91116-19-7
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl ester 3-chloropropyl ester

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{3-[(3,3-diphenyl-propyl)-methyl-amino]-propyl} ester 5-methyl ester

Conditions

Conditions	Yield
Heating;	35%

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 100427-02-9
4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-1-methyl-ethyl) ester 5-isobutyl ester

: 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-1-methyl-ethyl} ester 5-isobutyl ester

Conditions

Conditions	Yield
Heating;	5%

: 74509-66-3
(6-bromo-hexyl)-diethyl-amine

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 103044-09-3
N-(3,3-Diphenyl-propyl)-N',N'-diethyl-N-methyl-hexane-1,6-diamine

Conditions

Conditions	Yield
With sodium carbonate In ethanol

: 5414-21-1
5-bromopentan-1-nitrile

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 102470-42-8
5-[(3,3-Diphenyl-propyl)-methyl-amino]-pentanenitrile

Conditions

Conditions	Yield
With sodium carbonate In ethanol

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 100427-00-7
2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl ester 2-chloroethyl ester

: 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-ethyl} ester 5-methyl ester

Conditions

Conditions	Yield
Heating; Yield given;

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 92130-26-2
2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-chloroethyl)ester-5-methyl ester

: 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-ethyl} ester 5-methyl ester

Conditions

Conditions	Yield
Heating; Yield given;

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 100427-01-8
4-Benzo[1,2,5]oxadiazol-4-yl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-chloro-ethyl) ester 5-methyl ester

: 4-Benzo[1,2,5]oxadiazol-4-yl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-ethyl} ester 5-methyl ester

Conditions

Conditions	Yield
Heating; Yield given;

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(4-bromo-butyl) ester 5-methyl ester

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{4-[(3,3-diphenyl-propyl)-methyl-amino]-butyl} ester 5-methyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 16h; Ambient temperature; Yield given;

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 54527-89-8
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-chloroethyl)ester-5-methyl ester

: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl-propyl)-methyl-amino]-ethyl} ester 5-methyl ester

Conditions

Conditions	Yield
Heating; Yield given;

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine

: N2-(3,3-diphenyl-propyl)-6,7-dimethoxy-N2-methyl-quinazoline-2,4-diamine

Conditions

Conditions	Yield
In i-Amyl alcohol for 5h; Heating;

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: (R)-1-{2-[(3,3-Diphenyl-propyl)-methyl-amino]-ethyl}-piperidine-3-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 36 percent / K2CO3 / acetone / 504000 h / 20 °C 2: aq. NaOH / ethanol / 20 °C View Scheme

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 100427-26-7
lercanidipine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / xylene / 8.5 h / Heating 2: 72 percent / toluene / 2 h / 80 °C 3: 91 percent / HCl / CHCl3 / 15 °C 4: propan-2-ol / Heating View Scheme
Multi-step reaction with 2 steps 1: 80 percent / xylene / 8.5 h / Heating 2: dimethylformamide; CH2Cl2 / 3 h / 0 °C View Scheme

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 4-[N-(3,3-diphenylpropyl)-N-methylamino]-2-butanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / diethyl ether / -5 - 3 °C 2: 83 percent / NaBH4 / methanol / 0.08 h / 0 °C View Scheme

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 100427-51-8
1,1,N-trimethyl-N-(3,3-diphenylpropy)-2-aminoethyl acetoacetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / xylene / 8.5 h / Heating 2: 72 percent / toluene / 2 h / 80 °C View Scheme

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 100427-52-9
3-Oxo-butyric acid 2-[(3,3-diphenyl-propyl)-methyl-amino]-1-methyl-ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 percent / methanol / 96 h / 15 - 20 °C 2: 68 percent / toluene / 95 °C View Scheme

: 28075-29-8
N-methyl-3,3-diphenylpropylamine

: 210579-46-7
2-[1-(2,3-Dichloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid 2-[(3,3-diphenyl-propyl)-methyl-amino]-1-methyl-ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 70 percent / methanol / 96 h / 15 - 20 °C 2: 68 percent / toluene / 95 °C 3: 93 percent / HCl / CHCl3 / 24 h / Ambient temperature View Scheme

N-Methyl-3,3-diphenylpropylamine Specification

The Benzenepropanamine,N-methyl-gamma-phenyl-, with the CAS registry number 28075-29-8, is also known as N-Methyl-3,3-diphenyl-1-propanamine. Its EINECS number is 248-821-5. This chemical's molecular formula is C₁₆H₁₉N and formula weight is 225.33. What's more, its IUPAC name is called N-methyl-3,3-diphenylpropan-1-amine. This chemical is white crystals.

Physical properties of Benzenepropanamine,N-methyl-gamma-phenyl-: (1)ACD/LogP: 2.59; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.5; (4)ACD/LogD (pH 7.4): -0.2; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.554; (14)Molar Refractivity: 73.06 cm³; (15)Molar Volume: 227.9 cm³; (16)Surface Tension:37.5 dyne/cm; (17)Density: 0.988 g/cm³; (18)Flash Point: 164.5 °C; (19)Enthalpy of Vaporization: 59.16 kJ/mol; (20)Boiling Point: 347.4 °C at 760 mmHg; (21)Vapour Pressure: 5.41E-05 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:c1ccccc1C(c2ccccc2)CCNC
(2)InChI:InChI=1/C16H19N/c1-17-13-12-16(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16-17H,12-13H2,1H3
(3)InChIKey:AKEGHAUFMKCWGX-UHFFFAOYAA

Product Name

N-Methyl-3,3-diphenylpropylamine

Synthetic route

N-Methyl-3,3-diphenylpropylamine Specification

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