N,N-Dimethylisopropylamine supplier

Name
N,N-Dimethylisopropylamine
EINECS 213-635-5
CAS No. 996-35-0
Article Data25
CAS DataBase
Density 0.734 g/cm³
Solubility 100g/L at 25℃
Melting Point -115.88°C (estimate)
Formula C₅H₁₃N
Boiling Point 65.8 °C at 760 mmHg
Molecular Weight 87.1649
Flash Point -9 °C
Transport Information UN 2733
Appearance Clear liquid
Safety 16-26-29-36/37/39-45-61
Risk Codes 11-34-51/53
Molecular Structure
Hazard Symbols
Synonyms Dimethylisopropylamine;
PSA 3.24000
LogP 0.95640

Synthetic route

: 124-40-3
dimethyl amine

: 67-64-1
acetone

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
With hydrogen; ZrO2-containing catalyst at 80 - 170℃; under 150015 Torr;	99%
With water; hydrogen; platinum at 25℃; under 2280 Torr; Ueberdruck;

: 917-64-6
methyl magnesium iodide

: 5350-67-4
α-(dimethylamino)-propionitrile

A: 996-35-0
N,N-dimethylisopropyl amine

B: 10524-60-4
3-(dimethylamino)-2-butanone

Conditions

Conditions	Yield
With diethyl ether
reagiert analog mit Aethylmagnesiumbromid; mit Propylmagnesiumbromid und mit Cyclohexylmagnesiumchlorid nur die entspr.Ketone erhalten werden;

...Expand

: 50-00-0
formaldehyd

: 15572-56-2
isopropylamine hydrochloride

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
at 135℃;

: 4995-18-0
N,N,N-Trimethylisopropylammonium iodide

: 141-43-5
ethanolamine

A: 996-35-0
N,N-dimethylisopropyl amine

B: 75-50-3
trimethylamine

Conditions

Conditions	Yield
at 154℃; Rate constant;

...Expand

: 50-00-0
formaldehyd

: 75-31-0
isopropylamine

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
With formic acid; water
With formic acid
With formic acid

: 917-64-6
methyl magnesium iodide

: 1783-25-1
N1,N1-dimethyl-N2-phenylformamidine

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
(i) AcCl, (ii) /BRN= 1209226/; Multistep reaction;

: 187737-37-7
propene

: 110-18-9
N,N,N,N,-tetramethylethylenediamine

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
With ethyllithium at 150℃;

: 10556-98-6
1,3,5-Triisopropyl-1,3,5-triazacyclohexane

: 91076-68-5
mono-trimethylsilylphosphite

A: 996-35-0
N,N-dimethylisopropyl amine

B: 4747-21-1
N-methylpropan-2-amine

...Expand

: 126191-35-3
2-(tert-Butylazo)-2(dimethylamino)propane

A: 996-35-0
N,N-dimethylisopropyl amine

B: 75-28-5
Isobutane

C: 22499-75-8
Acetone N,N-dimethylenamine

D: 22752-64-3
2-Dimethylamino-4-methyl-pentadien-(1,3)

E: 124-40-3
dimethyl amine

F: 67-64-1
acetone

Conditions

Conditions	Yield
In benzene-d6 Mechanism; Product distribution; Heating;

...Expand

: 126191-35-3
2-(tert-Butylazo)-2(dimethylamino)propane

A: 996-35-0
N,N-dimethylisopropyl amine

B: 75-28-5
Isobutane

C: 33050-99-6
acetone tert-butylhydrazone

D: 13952-69-7
1,2-di-tert-butylhydrazine

E: 124-40-3
dimethyl amine

F: 67-64-1
acetone

Conditions

Conditions	Yield
In [D3]acetonitrile Mechanism; Product distribution; Heating; solvent wet or dried;

...Expand

: 126191-35-3
2-(tert-Butylazo)-2(dimethylamino)propane

A: 996-35-0
N,N-dimethylisopropyl amine

B: 75-28-5
Isobutane

C: 3733-36-6
dimethyl-(1,1,2,2-tetramethyl-propyl)-amine

D: 124-40-3
dimethyl amine

E: 67-64-1
acetone

F: 115-11-7
isobutene

Conditions

Conditions	Yield
In benzene-d6 Mechanism; Product distribution; Irradiation; other solvent (wet CD3CN);

...Expand

: 126191-35-3
2-(tert-Butylazo)-2(dimethylamino)propane

A: 996-35-0
N,N-dimethylisopropyl amine

B: 75-28-5
Isobutane

C: 3733-36-6
dimethyl-(1,1,2,2-tetramethyl-propyl)-amine

D: 33050-99-6
acetone tert-butylhydrazone

E: 124-40-3
dimethyl amine

F: 115-11-7
isobutene

Conditions

Conditions	Yield
In sodium hydroxide; d(4)-methanol Mechanism; Product distribution; Heating; or CH3OD / NaOH;

...Expand

: 126191-35-3
2-(tert-Butylazo)-2(dimethylamino)propane

A: 996-35-0
N,N-dimethylisopropyl amine

B: 33050-99-6
acetone tert-butylhydrazone

C: 13952-69-7
1,2-di-tert-butylhydrazine

D: 124-40-3
dimethyl amine

E: 115-11-7
isobutene

Conditions

Conditions	Yield
In d(4)-methanol Mechanism; Product distribution; Irradiation; other solvents;

...Expand

: N'-Eth-(E)-ylidene-N-isopropyl-N,N-dimethyl-hydrazinium; iodide

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
With potassium hydroxide In methanol for 0.5h; Heating; Yield given;

: 124-40-3
dimethyl amine

: 67-64-1
acetone

platinum: platinum

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
under 2280 Torr; Hydrogenation;

...Expand

: 60-29-7
diethyl ether

: 2273-40-7
2-dimethylamino-2-methylpropionitrile

sodium: sodium

: 996-35-0
N,N-dimethylisopropyl amine

...Expand

: FeC10H9CH2N(CH3)2CH(CH3)2(1+)*Br(1-)={FeC10H9CH2N(CH3)2CH(CH3)2}Br

A: (Fe(C5H5)(C5H4CH2))2N(CH3)2(1+)

B: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
In not given
In not given

: 758-16-7
N,N-dimethylthioformamide

: 75-16-1
methylmagnesium bromide

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
In tetrahydrofuran; 1,2-dichloro-ethane at 20℃; Inert atmosphere; Reflux;

: 50-00-0
formaldehyd

: 64-18-6
formic acid

: 75-31-0
isopropylamine

: 996-35-0
N,N-dimethylisopropyl amine

Conditions

Conditions	Yield
Eschweiler-Clark Amine Methylation;

...Expand

: 103-30-0
(E)-1,2-diphenyl-ethene

: 996-35-0
N,N-dimethylisopropyl amine

: 76233-40-4
(2,3-Diphenyl-propyl)-isopropyl-methyl-amine

Conditions

Conditions	Yield
Irradiation;	95%

: 910650-82-7
1-fluoro-1,1-bis(phenylsulfonyl)methane

: 996-35-0
N,N-dimethylisopropyl amine

: 1438847-91-6
N-(2-fluoro-2,2-bis(phenylsulfonyl)ethyl)-N-methylpropan-2-amine

Conditions

Conditions	Yield
Stage #1: N,N-dimethylisopropyl amine With di-isopropyl azodicarboxylate at 0 - 20℃; for 1h; Schlenk technique; Stage #2: 1-fluoro-1,1-bis(phenylsulfonyl)methane In N,N-dimethyl-formamide at 50℃; for 3h; regioselective reaction;	95%

: 996-35-0
N,N-dimethylisopropyl amine

: 1218938-71-6
N,N-dimethylisopropylammonium azide

Conditions

Conditions	Yield
With hydrogen azide In diethyl ether at 0 - 10℃; for 6h;	92%

: 996-35-0
N,N-dimethylisopropyl amine

: 2-(benzenesulfonyl)-6-chlorobenzothiazole

: C12H15ClN2S

Conditions

Conditions	Yield
With di-tert-butoxydiazene In methanol at 50℃; for 8h;	91%

: 1722-12-9
2-chloropyrimidine

: 996-35-0
N,N-dimethylisopropyl amine

A: 5621-02-3
2-(dimethylamino)pyrimidine

B: 141193-17-1
Isopropyl-methyl-pyrimidin-2-yl-amine

Conditions

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 6% B 90%

...Expand

: 996-35-0
N,N-dimethylisopropyl amine

: 1245771-19-0
2-(benzenesulfonyl)-5-phenyloxazole

: C14H18N2O

Conditions

Conditions	Yield
With di-tert-butoxydiazene In methanol at 50℃; for 8h;	90%

: 27302-34-7
1-(benzenesulfonyl)isoquinoline

: 996-35-0
N,N-dimethylisopropyl amine

: C14H18N2

Conditions

Conditions	Yield
With sodium dihydrogenphosphate; di-tert-butoxydiazene In methanol at 50℃; for 24h;	90%

: 996-35-0
N,N-dimethylisopropyl amine

: 2-(benzenesulfonyl)-4-(ethoxycarbonyl)thiazole

: C11H18N2O2S

Conditions

Conditions	Yield
With di-tert-butoxydiazene In ethanol at 50℃; for 8h;	89%

: 996-35-0
N,N-dimethylisopropyl amine

: 28525-13-5
4-(phenylsulfonyl)benzonitrile

: 928649-05-2
[(4-cyanophenyl)methyl](methyl)(isopropyl)amine

Conditions

Conditions	Yield
With sodium dihydrogenphosphate; di-tert-butoxydiazene In methanol at 50℃; for 24h; Reagent/catalyst;	88%

: 71274-57-2
2-phenylsulphonyl-1,3-thiazole

: 996-35-0
N,N-dimethylisopropyl amine

: isopropyl(methyl)(2-thiazolylmethyl)amine

Conditions

Conditions	Yield
With di-tert-butoxydiazene In methanol at 50℃; for 8h;	87%

: 996-35-0
N,N-dimethylisopropyl amine

: 2-(benzenesulfonyl)-6-methoxybenzothiazole

: isopropyl[2-(6-methoxybenzothiazolyl)methyl](methyl)amine

Conditions

Conditions	Yield
With di-tert-butoxydiazene In methanol at 50℃; for 8h;	87%

: 996-35-0
N,N-dimethylisopropyl amine

: 2-(benzenesulfonyl)-1-methylbenzimidazole

: C13H19N3

Conditions

Conditions	Yield
With di-tert-butoxydiazene In methanol at 50℃; for 8h;	85%

: 996-35-0
N,N-dimethylisopropyl amine

: 38337-00-7
methyl 4-(benzenesulfonyl)benzoate

: isopropyl[4-(methoxycarbonyl)phenylmethyl](methyl)-amine

Conditions

Conditions	Yield
With sodium dihydrogenphosphate; di-tert-butoxydiazene In methanol at 50℃; for 24h;	83%

: 141-30-0
3,6-dichlorpyridazine

: 996-35-0
N,N-dimethylisopropyl amine

A: 7145-60-0
6-chloro-N,N-dimethyl-pyridazin-3-amine

B: 141193-19-3
(6-Chloro-pyridazin-3-yl)-isopropyl-methyl-amine

Conditions

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 6% B 82%

...Expand

: 996-35-0
N,N-dimethylisopropyl amine

: 3376-26-9
N-Benzylidenebenzylamine N-oxide

: C19H26N2O

Conditions

Conditions	Yield
With 4,4'-Dichlorobenzophenone In acetone at 20℃; for 1h; Solvent; Wavelength; Reagent/catalyst; UV-irradiation; Inert atmosphere; regioselective reaction;	82%

: 542-69-8
1-iodo-butane

: 996-35-0
N,N-dimethylisopropyl amine

: butyldimethylisopropylammonium iodide

Conditions

Conditions	Yield
In butanone for 3h; Menshutkin reaction; Heating;	81%

: 996-35-0
N,N-dimethylisopropyl amine

: 75-09-2
dichloromethane

: 762-04-9
phosphonic acid diethyl ester

: diethyl (N-isopropylmethylaminomethyl)phosphonate

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;	80%

...Expand

: 615-20-3
2-chlorobenzo[d][1,3]thiazole

: 996-35-0
N,N-dimethylisopropyl amine

A: 4074-74-2
2-dimethylaminobenzothiazole

B: 136540-11-9
Benzothiazol-2-yl-isopropyl-methyl-amine

Conditions

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 20% B 79%

...Expand

: 996-35-0
N,N-dimethylisopropyl amine

: 623-25-6
p-Xylylene dichloride

: 419532-61-9
4-(chloromethyl)-N-isopropyl-N,N-dimethylbenzenemethan-aminium chloride

Conditions

Conditions	Yield
In tetrahydrofuran	79%

: 996-35-0
N,N-dimethylisopropyl amine

: 75-03-6
ethyl iodide

: 105198-03-6
ethyldimethylisopropylammonium iodide

Conditions

Conditions	Yield
In butanone for 0.75h; Menshutkin reaction; Heating;	77%

: 996-35-0
N,N-dimethylisopropyl amine

: 183547-74-2
1-iodine-1H,1H,2H,2H,3H,3H-perfluoroheptane

: C12H19F9N(1+)*I(1-)

Conditions

Conditions	Yield
In acetonitrile at 150℃; for 24h; Schlenk technique;	76%

: 996-35-0
N,N-dimethylisopropyl amine

: 2-(benzenesulfonyl)-4-phenylthiazole

: C14H18N2S

Conditions

Conditions	Yield
With di-tert-butoxydiazene In methanol at 50℃; for 8h;	76%

: 996-35-0
N,N-dimethylisopropyl amine

: 79887-10-8
1-ethynyl-4-(n-pentyl)benzene

: 1118639-22-7
C18H27N

Conditions

Conditions	Yield
Stage #1: N,N-dimethylisopropyl amine With diethylazodicarboxylate at 0 - 20℃; for 1h; Inert atmosphere; Stage #2: 1-ethynyl-4-(n-pentyl)benzene With copper(l) iodide In tetrahydrofuran at 0 - 20℃; Inert atmosphere; regioselective reaction;	75%

: 996-35-0
N,N-dimethylisopropyl amine

: C15H12F3NO

: C20H25F3N2O

Conditions

Conditions	Yield
With 4,4'-Dichlorobenzophenone In acetone at 20℃; for 1h; Inert atmosphere; UV-irradiation; regioselective reaction;	75%

: 996-35-0
N,N-dimethylisopropyl amine

: 91822-75-2
2-(benzenesulfonyl)benzimidazole

: (2-benzimidazolylmethyl)(isopropyl)(methyl)amine

Conditions

Conditions	Yield
With di-tert-butoxydiazene In methanol at 50℃; for 8h;	75%

: 996-35-0
N,N-dimethylisopropyl amine

: 22661-25-2, 162740-08-1
C-(2-furyl)-N-benzylnitrone

: C17H24N2O2

Conditions

Conditions	Yield
With 4,4'-Dichlorobenzophenone In acetone at 20℃; for 3.5h; Inert atmosphere; UV-irradiation; regioselective reaction;	74%

: 996-35-0
N,N-dimethylisopropyl amine

: 81269-96-7
4-Chloro-2,6-bis(trifluoromethyl)pyridine

A: 136540-06-2
(2,6-Bis-trifluoromethyl-pyridin-4-yl)-dimethyl-amine

B: 136540-04-0
(2,6-Bis-trifluoromethyl-pyridin-4-yl)-isopropyl-methyl-amine

Conditions

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 13% B 73%

...Expand

: 996-35-0
N,N-dimethylisopropyl amine

: N-benzyl-C-(2-pyridyl) nitrone

: C18H25N3O

Conditions

Conditions	Yield
With 4,4'-Dichlorobenzophenone In acetone at 20℃; for 1h; Inert atmosphere; UV-irradiation; regioselective reaction;	72%

: 996-35-0
N,N-dimethylisopropyl amine

: 62-53-3
aniline

: 100-61-8
N-methylaniline

Conditions

Conditions	Yield
With palladium 10% on activated carbon In toluene at 175℃; for 1.5h; Inert atmosphere; Microwave irradiation;	70%

N,N-Dimethylisopropylamine Specification

The N,N-Dimethylisopropylamine, with the CAS registry number of 996-35-0, is also known as Dimethylisopropylamine. It belongs to the product categories of Amines; C2 to C6; Nitrogen Compounds. Its EINECS registry number is 213-635-5. This chemical's molecular formula is C₅H₁₃N and molecular weight is 87.16. What's more, both its systematic name and IUPAC name are the same which is called N,N-Dimethylpropan-2-amine. In addition, it must be stored in airtight containers and placed in a dry, cool place.

Physical properties about the N,N-Dimethylisopropylamine are: (1)ACD/LogP: 0.94; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.14; (4)ACD/LogD (pH 7.4): -1.47; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 3.24 Å²; (13)Index of Refraction: 1.401; (14)Molar Refractivity: 28.89 cm³; (15)Molar Volume: 118.6 cm³; (16)Surface Tension: 21 dyne/cm; (17)Density: 0.734 g/cm³; (18)Enthalpy of Vaporization: 30.78 kJ/mol; (19)Boiling Point: 65.8 °C at 760 mmHg; (20)Vapour Pressure: 155 mmHg at 25 °C.

Uses: it is used to produce other chemicals. For example, it is used to produce Isopropyl-methyl-pyrimidin-2-yl-amine and Dimethyl-pyrimidin-2-yl-amine. This reaction needs reagent 2-Chloro-pyrimidine and solvent Tetrahydrofuran. Other condition of this reaction is reaction time of 4 days at 100°C. The yield is about 90 %.

When you are using this chemical, please be cautious about it as the following:
As a chemical, it is highly flammable, toxic to aquatic organisms, and may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. During using it, wear suitable protective clothing, gloves and eye/face protection. Besides, it may causes burns and you should avoid release it to the environment or empty into drains.

You can still convert the following datas into molecular structure:
(1) SMILES:N(C(C)C)(C)C
(2) InChI:InChI=1/C5H13N/c1-5(2)6(3)4/h5H,1-4H3
(3) InChIKey:VMOWKUTXPNPTEN-UHFFFAOYAZ

Product Name

N,N-Dimethylisopropylamine

Synthetic route

N,N-Dimethylisopropylamine Specification

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