N-Succinimidyl maleimidoacetate

This chemical is called N-Succinimidyl maleimidoacetate, and its systematic name is 1-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}-1H-pyrrole-2,5-dione. With the molecular formula of C₁₀H₈N₂O₆, its molecular weight is 252.18. The CAS registry number of this chemical is 55750-61-3, and its product categories are Nitric Oxide Reagents; Cross Linking Reagents; Maleimide Derivatives; Crosslinking; Heterobifunctional Cross-Linking Reagents; Protein Modification. In addition, this chemical should be stored at the temperature of −20 °C.

Other characteristics of the N-Succinimidyl maleimidoacetate can be summarised as followings: (1)ACD/LogP: -2.21; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.21; (4)ACD/LogD (pH 7.4): -2.21; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.49; (8)ACD/KOC (pH 7.4): 1.49; (9)#H bond acceptors: 8; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 101.06 Å²; (13)Index of Refraction: 1.619; (14)Molar Refractivity: 54.25 cm³; (15)Molar Volume: 154.4 cm³; (16)Polarizability: 21.5×10^-24cm³; (17)Surface Tension: 77.2 dyne/cm; (18)Density: 1.63 g/cm³; (19)Flash Point: 213.9 °C; (20)Enthalpy of Vaporization: 68.55 kJ/mol; (21)Boiling Point: 430.1 °C at 760 mmHg; (22)Vapour Pressure: 1.33E-07 mmHg at 25 °C.

Production method of this chemical: The N-Succinimidyl maleimidoacetate could be obtained the reactants of N-hydroxy-succinimide and N,N-maleoyl-glycine, the reagent of dicyclohexylcarbodiimide (DCC), and the solvent of tetrahydrofuran. The yield is 57 %. In addition, this reaction should be taken for 48 hours at the temperature of 4 °C. 

Uses of this chemical: The 17-(cyclopropylmethyl)-4,5a-epoxy-3,14-dihydroxy-6b-(maleimidoacetamido)morphinan could be obtained by the reactants of 6b-amino-17-cyclopropylmethyl-4,5a-epoxy-morphinane-3,14-diol and N-Succinimidyl maleimidoacetate, and the solvent of tetrahydrofuran. The yield is 71 %.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin, so you should wear suitable protective clothing when you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: O=C2N(OC(=O)CN1C(=O)\C=C/C1=O)C(=O)CC2
2.InChI: InChI=1/C10H8N2O6/c13-6-1-2-7(14)11(6)5-10(17)18-12-8(15)3-4-9(12)16/h1-2H,3-5H2
3.InChIKey: TYKASZBHFXBROF-UHFFFAOYAO