-
Name
NOCODAZOLE
- EINECS 250-626-5
- CAS No. 31430-18-9
- Article Data3
- CAS DataBase
- Density 1.491 g/cm3
- Solubility DMSO: 10 mg/mL, soluble
- Melting Point 300 °C (dec.)
- Formula C14H11N3O3S
- Boiling Point
- Molecular Weight 301.326
- Flash Point
- Transport Information UN 2811
- Appearance Amber powder
- Safety 53-45-36/37/39-26
- Risk Codes 61-40-36/37/38-34-11
-
Molecular Structure
-
Hazard Symbols
T, 
C, 
F
- Synonyms 2-Benzimidazolecarbamicacid, 5-(2-thenoyl)-, methyl ester (8CI);Carbamic acid,[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester (9CI);Methyl[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate;N-[5-(2-Thenoyl)-2-benzimidazolyl]carbamic acid methyl ester;NSC 238159;Oncodazole;R 17934;
- PSA 112.32000
- LogP 3.10670
Nocodazole Chemical Properties
MF: C14H11N3O3S
MW: 301.32
EINECS: 250-626-5
mp: 300 °C (dec.)
storage temp: 2-8°C
solubility DMSO: 10 mg/mL, soluble
form: powder
color: white
Synonyms:[5-(2-THIENYLCARBONYL)-1H-BENZIMIDAZOL-2-YL]CARBONIC ACID, METHYL ESTER;METHYL[5-(2-THIENYLCARBONYL)-1H-BENZIMADAZOL-2-YL]CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMIDAZOL-2-YL)CARBAMATE;METHYL [5-(2-THIENYLCARBONYL)-1H-BENZ-IMIDAZOLE-2-YL]-CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMODAZOL-2YL)-CARBAMATE;METHYL N-(5-THENOYL-2-BENZIMIDAZOLYL)CARBAMATE;NOCODAZOLE;R 17934
Molecular Structure:
MW: 301.32
EINECS: 250-626-5
mp: 300 °C (dec.)
storage temp: 2-8°C
solubility DMSO: 10 mg/mL, soluble
form: powder
color: white
Synonyms:[5-(2-THIENYLCARBONYL)-1H-BENZIMIDAZOL-2-YL]CARBONIC ACID, METHYL ESTER;METHYL[5-(2-THIENYLCARBONYL)-1H-BENZIMADAZOL-2-YL]CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMIDAZOL-2-YL)CARBAMATE;METHYL [5-(2-THIENYLCARBONYL)-1H-BENZ-IMIDAZOLE-2-YL]-CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMODAZOL-2YL)-CARBAMATE;METHYL N-(5-THENOYL-2-BENZIMIDAZOLYL)CARBAMATE;NOCODAZOLE;R 17934
Molecular Structure:
Nocodazole Uses
ONCODAZOLE is used as a synthetic chemotherapeutic agent with antineoplastic, antifungal and anthelmintic activities. Microtubule inhibitor; inhibits mitosis.
Nocodazole Toxicity Data With Reference
| 1. | sln-smc 1 ppm/16H | MUREAV Mutation Research. 141 (1984),15. | ||
| 2. | cyt-hmn:hla 40 µg/L | CNREA8 Cancer Research. 36 (1976),905. | ||
| 3. | ipr-mus LD50:39,350 µg/kg | NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 . |
Nocodazole Safety Profile
Poison by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx. See also CARBAMATES.
Hazard Codes T,C,F
Risk Statements 61-40-36/37/38-34-11
Safety Statements 53-45-36/37/39-26-16
RIDADR 2811
WGK Germany 3
RTECS DD6521000
HazardClass 6.1(b)
PackingGroup III
Hazard Codes T,C,F
Risk Statements 61-40-36/37/38-34-11
Safety Statements 53-45-36/37/39-26-16
RIDADR 2811
WGK Germany 3
RTECS DD6521000
HazardClass 6.1(b)
PackingGroup III
Nocodazole Specification
Handling and Storage of ONCODAZOLE:
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a tightly closed container. Store in a dry area. Deep freeze (below -20°C).
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