Norvaline supplier | CasNO.6600-40-4

Name
L-norvaline
EINECS 229-543-3
CAS No. 6600-40-4
Article Data64
CAS DataBase
Density 1.067 g/cm³
Solubility 10.5 g/100 mL (18 °C) in water
Melting Point >300 °C(lit.)
Formula C₅H₁₁NO₂
Boiling Point 222.9 °C at 760 mmHg
Molecular Weight 117.148
Flash Point 88.6 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 24/25-37/39-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols C, Xn
Synonyms L-Norvaline (9CI);Norvaline, L-;L-2-Aminovaleric acid;L-2-aminopentanoate;(S)-2-Aminopentanoic acid;L-(+)-2-aminovaleric acid;L-2-aminopentanoic acid;(2S)-2-aminopentanoic acid;alpha-L-Aminopentanoic acid;Leucine,2-methyl-;Pentanoic acid, 2-amino-, (S)-;L-Norvaaline;L(+)-Norvaline;(S)-2-Amino-pentanoic acid;
PSA 63.32000
LogP 0.89870

Synthetic route

: 1821-02-9
2-oxopentanoic acid

A: 2013-12-9
D-norvaline

B: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With CC10H14NOSCH2CH2CH3N(CH3)2 (5); zinc diacetate In methanol at 30℃; Product distribution; pH 4.00; other reagent;	A 95% B 5%
With 5-((3-(dimethylamino)propyl)thio)-4-(aminomethyl)-3-hydroxyl-5,6,7,8-tetraquinoline In methanol at 30℃; Product distribution; stereoselective transaminations at pH=4.00, various reagents;	A 96 % Chromat. B 4 % Chromat.
With C12H18N4O2*ClH; 2,2-diphenylglycine In methanol; water at 20℃; for 6h; enantioselective reaction;	A n/a B n/a
With isopropylamine In aq. buffer for 48h; pH=7.0; Time; Enzymatic reaction; Overall yield = 90 %;	A n/a B n/a

: 100516-55-0
(3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(2'-propenyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogen; palladium dichloride In tetrahydrofuran; ethanol under 2068.6 Torr; for 21h;	93%
With hydrogen; palladium dichloride In ethanol at 25℃; under 1034.3 Torr; Yield given;

: 141895-39-8
(1S,2S,5S,9S)-2,10,10-Trimethyl-5-propyl-3-oxa-6-aza-tricyclo[7.1.1.02,7]undec-6-en-4-one

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran at 70℃; for 3h;	92%

: 1821-02-9
2-oxopentanoic acid

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With sodium formate; ammonium chloride; NADH In aq. phosphate buffer at 25℃; for 6h; pH=8.0; Kinetics; Reagent/catalyst; Green chemistry; Enzymatic reaction;	84.1%
With glutamate dehydrogenase; L-glutamic acid; pyridoxal 5'-phosphate; alcohol dehydrogenases from Bacillus stearothermophilus; branched-chain amino acid aminotransferase; NADH In isopropyl alcohol at 35℃; for 5h; pH=8; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;	59.1%
With L-2-aminobutyric acid; branched-chain transaminase from Escherichiacoli; S-selective ω-transaminase from Ochrobactrum anthropi; (3-hydroxy-5-hydroxymethyl)-2-methylisonicotinic acid 5-phosphate; isopropylamine In aq. phosphate buffer for 9h; pH=7;	n/a

: 1116-19-4, 2325-18-0, 39537-36-5, 61500-92-3, 95191-59-6, 103067-82-9
DL-α-alanyl-DL-norvaline

A: 56-41-7
L-alanin

B: 338-69-2
D-Alanine

C: 2013-12-9
D-norvaline

D: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With (S)-1-(N,N-dimethylaminomethyl)-2-formylcymantrene; sodium methylate; copper (I) acetate for 1h; Ambient temperature;	A 78.31% B 21.69% C 60.57% D 39.43%
With (S)-1-(N,N-dimethylaminomethyl)-2-formylcymantrene; sodium methylate; copper (I) acetate for 3h; Ambient temperature;	A 76.83% B 23.15% C 73.8% D 26.2%
With (R)-1-(N,N-dimethylaminomethyl)-2-formylcymantrene; sodium methylate; copper (I) acetate for 1h; Ambient temperature;	A 26.8% B 73.2% C 42.16% D 57.84%
With (R)-1-(N,N-dimethylaminomethyl)-2-formylcymantrene; sodium methylate; copper (I) acetate for 1h; Ambient temperature;	A 26.8% B 73.2% C 42.16% D 57.84%

...Expand

: 220515-19-5
tert-butyl-(2S,3S)-1,2-dihydroxyhexan-3-ylcarbamate

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
Stage #1: tert-butyl-(2S,3S)-1,2-dihydroxyhexan-3-ylcarbamate With ruthenium trichloride; sodium periodate In tetrachloromethane; water; acetonitrile for 2h; Stage #2: With hydrogenchloride In tetrahydrofuran for 12h; Heating;	65%

: 127700-63-4
(2S)-(N-para-toluenesulphonylamino)pentanoic acid tert-butyl ester

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid; phenol for 24h; Ambient temperature;	62%
With hydrogen bromide; acetic acid 1.) phenol, 25 deg C, 24 h;

: 631921-64-7
((S)-1-Cyano-butyl)-carbamic acid methyl ester

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogenchloride In water for 7h; Heating;	60%

: (2S)-[(1'R)-phenylethylamino]-4-pentenoic acid

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogen; palladium on carbon In water at 50℃; under 16501.7 Torr; for 47h;	41.5%

: 7682-15-7, 15891-50-6, 57357-56-9
N-acetylnorvaline

A: 6600-40-4
L-Norvaline

B: 57357-56-9
N-acetyl-D-norvaline

Conditions

Conditions	Yield
With potassium hydroxide; Aspergillus acylase I pH 7.5-8.0; Yields of byproduct given;	A 33% B n/a
With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I at 40℃; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2;
With lipase AS 'Amano' at 35℃; for 24h; pH=6.5; Enzymatic reaction; enantioselective reaction;	A n/a B n/a

: 13123-54-1
α-ketovalerate

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With L-glutamic acid; pyridoxal 5'-phosphate In water at 40℃; for 18h; E.coli Aspartate transaminase, pH 8;	32%
With pyridoxal 5'-phosphate; Paracoccus denitrificans ω-transaminase; isopropylamine In aq. phosphate buffer for 1.66667h; pH=7; Enzymatic reaction;

: 112624-75-6
N-formyl-D,L-norvaline

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
beim Verseifen;
Multi-step reaction with 2 steps 2: Hydrolysis View Scheme
With water; cobalt(II) chloride for 0.8h; pH=8; Enzymatic reaction;

: 112624-75-6
N-formyl-L-norvaline

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
Hydrolysis;

: 7682-15-7, 15891-50-6, 57357-56-9
N-acetylnorvaline

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With (R)-1-phenyl-ethyl-amine
With acylase from Aspergillus oryzae; water at 20 - 37℃;

: 6940-47-2
N-Chloroacetyl norvaline

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
mit Hilfe eines Enzym-Praeparats aus Schweine-Nieren;

: 100196-24-5
N,N-dibenzyl-L-norvaline

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogenchloride; palladium Hydrogenation;

: 760-78-1
2-aminopentanoic acid

A: 2013-12-9
D-norvaline

B: 6600-40-4
L-Norvaline

: 15891-50-6
N-Acetyl-L-2-aminopentanoic acid

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With Aspergillus oryzae acylase relative rates;
With pig kidney acylase I In phosphate buffer at 37℃; for 0.166667h; pH=7.4; Enzyme kinetics; Deacetylation;

: 6940-47-2
N-Chloroacetyl norvaline

A: 6600-40-4
L-Norvaline

B: 910886-24-7
N-Chloroacetyl D-norvaline

Conditions

Conditions	Yield
With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I at 40℃; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2;

: 106749-04-6
(R)-2-Azido-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

A: 2013-12-9
D-norvaline

B: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With titanium tetrakis(benzyl alkoxide); hydrogen; Pd-BaSO4 1.) benzyl alcohol, 130 gradC 2.) EtOH, 1 atm, r.t.; Yield given. Multistep reaction. Yields of byproduct given;

: 121703-97-7
N-Methoxyacetyl norvaline

A: 6600-40-4
L-Norvaline

B: 121703-97-7
N-Methoxyacetyl D-norvaline

Conditions

Conditions	Yield
With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I at 40℃; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2;

: 2-[(2,4-Dinitro-phenyl)-hydrazono]-pent-4-enoic acid

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In ethanol for 1h;

: 5804-85-3
diethylaluminium cyanide

: 188447-84-9
(S)-N-(butylidene)-4-methylbenzenesulfinamide

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogenchloride 1.) Et2O, from -78 to -15 degC; 2.) reflux; Yield given. Multistep reaction;

: 5804-85-3
diethylaluminium cyanide

: 2-Methoxy-naphthalene-1-sulfinic acid (S)-but-(E)-ylideneamide

: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogenchloride 1.) THF, from -78 to -40 degC; 2.) reflux; Yield given. Multistep reaction;

: 80174-42-1
D,L-NorLeu-OBzl

A: 2013-12-9
D-norvaline

B: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With pyridoxal 5'-phosphate In water; tert-butyl alcohol at 40℃; for 4h; alcalase, pH=8.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With Alcalase; pyridoxal 5'-phosphate; water In tert-butyl alcohol at 40℃; for 4h; pH=8.5; racemization of D-enantiomer; kinetic res.; Title compound not separated from byproducts;

: 161633-98-3
(R)-2-((4S,5R)-2-Oxo-4,5-diphenyl-oxazolidin-3-yl)-pent-4-enoic acid benzyl ester

A: 2013-12-9
D-norvaline

B: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide In tetrahydrofuran; methanol under 3102.9 Torr; for 10.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 39256-85-4
ethyl 2-amino-L-butyrate

A: 2013-12-9
D-norvaline

B: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With phosphate buffer; Humicola amino esterase Ambient temperature; Title compound not separated from byproducts;

: 149207-93-2
2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pentanoic acid ethyl ester

A: 2013-12-9
D-norvaline

B: 6600-40-4
L-Norvaline

Conditions

Conditions	Yield
With water; chymotrypsin In acetonitrile for 208h; Yield given. Title compound not separated from byproducts;

: 23358-62-5, 40918-51-2
DL-norvaline ethyl ester; hydrochloride

: 6600-40-4
L-Norvaline

: 2-Amino-pentanoic acid propyl ester; hydrochloride

: 6600-40-4
L-Norvaline

: 85-44-9
phthalic anhydride

: 6600-40-4
L-Norvaline

: 58073-26-0
(S)-2-(1,3-dioxoisoindolin-2-yl)pentanoic acid

Conditions

Conditions	Yield
at 135℃;	100%
at 140℃; for 0.166667h;	98%
With triethylamine In toluene at 130℃; Dean-Stark;	37%
at 130℃;

: 6600-40-4
L-Norvaline

: 60702-69-4
2-chloro-4-fluorobenzonitrile

: N-(3-chloro-4-cyanophenyl)norvaline

Conditions

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 90℃;	100%

: 6600-40-4
L-Norvaline

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 150482-82-9
2-(2-nitro-benzenesulfonylamino)-pentanoic acid

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; water at 20℃; Cooling with ice;	100%

: 6600-40-4
L-Norvaline

: 123-41-1
cholin hydroxide

: C5H10NO2(1-)*C5H14NO(1+)

Conditions

Conditions	Yield
In water at 3℃; Darkness;	99%

: 6600-40-4
L-Norvaline

: 383-63-1
ethyl trifluoroacetate,

: 350-21-0
(S)-2-(2,2,2-trifluoroacetamido)pentanoic acid

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; for 24h;	99%

: 67-56-1
methanol

: 6600-40-4
L-Norvaline

: 56558-30-6
methyl L-norvalinate hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride Ambient temperature;	98%
With hydrogenchloride for 1h; Reflux;	98%
With hydrogenchloride for 6h; Reflux; Inert atmosphere;	97%

: 6600-40-4
L-Norvaline

: 407-25-0
trifluoroacetic anhydride

: 2357-40-6
4-propyl-2-(trifluoromethyl)oxazol-5(2H)-one

Conditions

Conditions	Yield
for 1h; Reflux;	97%

: 6600-40-4
L-Norvaline

: 24424-99-5
di-tert-butyl dicarbonate

: 53308-95-5
N-tert-butoxycarbonyl-L-norvaline

Conditions

Conditions	Yield
Stage #1: L-Norvaline With sodium hydroxide In tetrahydrofuran; water at 0℃; for 0.166667h; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran; water at 0 - 20℃; for 24h;	95%
Stage #1: L-Norvaline With sodium hydroxide In 1,4-dioxane; water for 6h; Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 20℃; Cooling with ice;	69.42%
With sodium hydroxide In 1,4-dioxane at 20℃;

: 6600-40-4
L-Norvaline

: 100-51-6
benzyl alcohol

: L-norvaline benzyl ester p-toluenesulphonate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Heating / reflux;	95%

: 64-17-5
ethanol

: 6600-40-4
L-Norvaline

: 104-15-4
toluene-4-sulfonic acid

: 440677-43-0
tosylate de L-norvalinate d'ethyle

Conditions

Conditions	Yield
In benzene for 10h; Heating;	94%

...Expand

: 12093-10-6
ferrocenecarboxaldehyde

: 6600-40-4
L-Norvaline

: 1310-73-2
sodium hydroxide

: sodium (S)-2-[(ferrocenylmethylidene)amino]pentanoate

Conditions

Conditions	Yield
With molecular sieve In ethanol under N2; aq. NaOH added to amino acid, soln. stirred at room temp. for 5 min, soln. concd. under vac., residue dried at 60°C (vac., 16 h), molecular sieves (4 Angstroem), ferrocenecarboxaldehyde and EtOH added, mixt. stirred (room temp., 16 h); molecular sieves filtered off, filtrate concd. under vac., residue suspd. in pentane, solid filtered off, washed with pentane, dried under vac.;	94%

Yield

With molecular sieve In ethanol under N2; aq. NaOH added to amino acid, soln. stirred at room temp. for 5 min, soln. concd. under vac., residue dried at 60°C (vac., 16 h), molecular sieves (4 Angstroem), ferrocenecarboxaldehyde and EtOH added, mixt. stirred (room temp., 16 h); molecular sieves filtered off, filtrate concd. under vac., residue suspd. in pentane, solid filtered off, washed with pentane, dried under vac.;

94%

...Expand

: 6600-40-4
L-Norvaline

: 270596-10-6
N-hydroxysuccinimide ester of 7-(1-carboxyethoxy)-4-phenylcoumarin

: 2-[2-(2-oxo-4-phenyl-2H-chromen-7-yloxy)-propionylamino]-pentanoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 1h; Condensation;	90.9%

: 6600-40-4
L-Norvaline

: 108-24-7
acetic anhydride

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
at 0 - 20℃;	89%

: 6600-40-4
L-Norvaline

: 112-13-0
n-decanoyl chloride

: (S)-2-decanamidopentanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran at 0℃; for 1h;	88.5%
With sodium hydroxide In tetrahydrofuran at 0℃; for 1h;	88.5%

: 6600-40-4
L-Norvaline

: (η6-p-cymene)Ru(acetylacetonate)chloride

: C15H24ClNO2Ru

Conditions

Conditions	Yield
In methanol for 24h;	88%

: 6600-40-4
L-Norvaline

: 1445869-56-6
C25H26N2O2

: 6018-89-9
nickel(II) acetate tetrahydrate

: C30H33N3NiO3

Conditions

Conditions	Yield
With potassium carbonate In ethanol at 60 - 70℃; diastereoselective reaction;	88%

...Expand

: 6600-40-4
L-Norvaline

: 90481-72-4
4-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole

: (1-tosyl-1H-indol-4-yl)-L-norvaline

Conditions

Conditions	Yield
With copper(l) iodide; caesium carbonate In dimethyl sulfoxide at 90℃; Inert atmosphere;	88%

: 6600-40-4
L-Norvaline

: 96-41-3
Cyclopentanol

: (S)-cyclopentyl 2-aminopentanoate hydrochloride

Conditions

Conditions	Yield
Stage #1: L-Norvaline; Cyclopentanol at -5℃; for 0.166667h; Cooling with acetone-dry ice; Stage #2: With thionyl chloride at 20 - 60℃; for 42h;	86%

: 6600-40-4
L-Norvaline

: 71-36-3
butan-1-ol

: (S)-2-Amino-pentanoic acid butyl ester

Conditions

Conditions	Yield
With hydrogenchloride	85%
With hydrogenchloride Heating;

: 6600-40-4
L-Norvaline

: 103290-07-9
(S)-2,5-dioxopyrrolidin-1-yl 2-((tert-butoxycarbonyl)amino)butanoate

: (S)-2-((S)-2-(tert-butoxycarbonylamino)butanamido)pentanoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; acetone at 20℃;	84%

: 6600-40-4
L-Norvaline

: 41014-93-1
2-(S)-hydroxyvaleric acid

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite In water at 0 - 5℃; for 1h;	82%
With hydrogenchloride; acetic acid; sodium nitrite
With hydrogenchloride; silver(I) nitrite
With hydrogenchloride; acetic acid; sodium nitrite at 0 - 20℃;
With sulfuric acid; sodium nitrite In water at 0℃; for 2h;

: 6600-40-4
L-Norvaline

: 32644-12-5
(2S)-2-chloropentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at 0℃;	82%
With hydrogenchloride; sodium nitrite at -5℃; for 15h;

: 10025-99-7
potassium tetrachloroplatinate(II)

: 6600-40-4
L-Norvaline

: trans-[PtCl2(L-norvaline)2]

Conditions

Conditions	Yield
With hydrogenchloride In potassium hydroxide; water org. compd. dissoln. in aq. KOH soln., aq. Pt-salt soln. addn., ppt. filtration off, concd. HCl addn. to filtrate, mixt. boiling for ca. 5 min, pptn.; ppt. filtration off, washing (HCl 1:1), drying at 100°C; elem. anal.;	80%

: 6600-40-4
L-Norvaline

: 105838-14-0
tert-butyl N-tosyloxycarbamate

: 1369519-86-7
C10H20N2O4

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane; water at 20 - 25℃; for 3h;	78%

: 6600-40-4
L-Norvaline

: 501-53-1
benzyl chloroformate

: 21691-44-1
Z-L-norvaline

Conditions

Conditions	Yield
With sodium hydroxide	77%
Stage #1: L-Norvaline; benzyl chloroformate With sodium hydrogencarbonate In water at 0 - 20℃; for 24.75h; Inert atmosphere; Stage #2: With hydrogenchloride In water pH=1;	73%
With sodium hydroxide; sodium carbonate In water at 0 - 20℃;
With lithium hydroxide In water; toluene at 0 - 20℃; for 15h;

Norvaline Specification

The IUPAC name of L-Norvaline is (2S)-2-aminopentanoic acid. With the CAS registry number 6600-40-4, it is also named as Pentanoic acid, 2-amino-. The product's categories are Chiral; Protected Amino Acid & Peptides; Norvaline [Nva]; Amino Acids; Unusual Amino Acids; Pharmaceutical Intermediates; Amino Acids. It is white to light yellow crystal powder which is a non-proteinogenic branched-chain amino acid.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.38; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.12; (4)ACD/LogD (pH 7.4): -2.12; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.463; (13)Molar Refractivity: 30.27 cm³; (14)Molar Volume: 109.7 cm³; (15)Polarizability: 12×10^-24 cm³; (16)Surface Tension: 41.9 dyne/cm; (17)Enthalpy of Vaporization: 50.61 kJ/mol; (18)Vapour Pressure: 0.0366 mmHg at 25°C; (19)Rotatable Bond Count: 3; (20)Exact Mass: 117.078979; (21)MonoIsotopic Mass: 117.078979; (22)Topological Polar Surface Area: 63.3; (23)Heavy Atom Count: 8; (24)Complexity: 82.5; (25)Defined Atom StereoCenter Count: 1.

Preparation of L-Norvaline: It can be obtained by 2-oxo-pentanoic acid anion. This reaction needs reagent pyridoxal phosphate, L-glutamic acid and solvent H₂O at temperature of 40 °C. The reaction time is 18 hours and the yield is 32%. The other conditions are E.coli Aspartate transaminase and pH 8.

Uses of L-Norvaline: It is known to promote tissue regeneration and muscle growth and become a precursor in the penicillin biosynthetic pathway. It also can be used for nutrition agent and drug synthesis. For example: it can react with phthalic acid anhydride to get N,N-phthaloyl-L-norvaline. This reaction reacts at 130 °C.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. So people should avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
1. SMILES:O=C(O)[C@@H](N)CCC
2. InChI:InChI=1/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
3. InChIKey:SNDPXSYFESPGGJ-BYPYZUCNBD

Product Name

L-norvaline

Synthetic route

Norvaline Specification

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