Norvaline, 5-hydroxy- supplier

Name
2-amino-5-hydroxyvaleric acid
EINECS
CAS No. 533-88-0
Article Data8
CAS DataBase
Density 1.241 g/cm³
Solubility
Melting Point 218-220℃
Formula C₅H₁₁NO₃
Boiling Point 306.1 °C at 760 mmHg
Molecular Weight 133.147
Flash Point 138.9 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Amino-5-hydroxypentanoicacid;5-Hydroxy-DL-norvaline;DL-d-Hydroxy-a-aminovalericacid;NSC 20896;Pentahomoserine;a-Amino-d-hydroxy-n-valericacid;a-Amino-d-hydroxyvaleric acid;d-Hydroxynorvaline;
PSA 83.55000
LogP -0.12890

Synthetic route

: 1191-99-7
2,3-dihydro-2H-furan

: 533-88-0
2-amino-5-hydroxyvaleric acid

Conditions

Conditions	Yield
beim aufeinanderfolgenden Behandeln mit NaCN, wss.HCl und NH4Cl, mit wss.2CO3 und mit wss. Ba(OH)2;

: 96-48-0
4-butanolide

: 95-92-1
oxalic acid diethyl ester

: 533-88-0
2-amino-5-hydroxyvaleric acid

Conditions

Conditions	Yield
With sulfuric acid und Hydrieren des Reaktionsprodukts an Raney-Nickel in wss.NH3;

: 45025-28-3
glutamic acid 5-ethyl ester

: 533-88-0
2-amino-5-hydroxyvaleric acid

Conditions

Conditions	Yield
With tetrahydrofuran; lithium borohydride

: 1499-55-4
glutamic acid γ-methyl ester

: 533-88-0
2-amino-5-hydroxyvaleric acid

Conditions

Conditions	Yield
Yield given. Multistep reaction;

δ-oxy-α-benzamino-n-valeric acid: δ-oxy-α-benzamino-n-valeric acid

: 533-88-0
2-amino-5-hydroxyvaleric acid

Conditions

Conditions	Yield
With hydrogenchloride

: 109-64-8
1,3-dibromo-propane

sodium compound of phthalimidomalonic acid ester: sodium compound of phthalimidomalonic acid ester

: 533-88-0
2-amino-5-hydroxyvaleric acid

Conditions

Conditions	Yield
at 165 - 170℃; ueber mehreren Stufen;

: 7647-01-0
hydrogenchloride

: 115938-76-6
2-benzoylamino-5-hydroxy-valeric acid

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 7664-93-9
sulfuric acid

: 115938-76-6
2-benzoylamino-5-hydroxy-valeric acid

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 67-56-1
methanol

: 533-88-0
2-amino-5-hydroxyvaleric acid

: methyl 2-amino-5-hydroxyvalerate

Conditions

Conditions	Yield
With sulfuric acid for 3h; Reflux;	90%

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 860256-02-6
5-hydroxy-2-(N'-phenyl-ureido)-valeric acid

Conditions

Conditions	Yield
With sodium hydroxide anschliessendes Behandeln mit Phenylisocyanat;

: 590-28-3
potassium cyanate

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 5-(3-hydroxy-propyl)-imidazolidine-2,4-dione

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 104092-74-2
5-hydroxy-2-oxo-pentanoic acid

Conditions

Conditions	Yield
With kidneys-substances
durch Einwirkung von Nieren-Praeparaten unter aeroben Bedingungen;

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 70-34-8
2,4-Dinitrofluorobenzene

: 22899-87-2
3-(2,4-dinitro-anilino)-tetrahydro-pyran-2-one

Conditions

Conditions	Yield
With ethanol; sodium hydrogencarbonate Ansaeuern des Reaktionsgemisches mit wss. Schwefelsaeure;

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 70-34-8
2,4-Dinitrofluorobenzene

: 108541-01-1
2-(2,4-dinitro-anilino)-5-hydroxy-valeric acid

Conditions

Conditions	Yield
With ethanol; sodium hydrogencarbonate

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 98-88-4
benzoyl chloride

: 115938-76-6
2-benzoylamino-5-hydroxy-valeric acid

Conditions

Conditions	Yield
With alkali

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 98-88-4
benzoyl chloride

: 2-benzoylamino-5-benzoyloxy-valeric acid

Conditions

Conditions	Yield
With alkali

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 79-04-9
chloroacetyl chloride

: 2-(2-chloro-acetylamino)-5-hydroxy-valeric acid

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 98-88-4
benzoyl chloride

N,O-dibenzoyl-δ-oxy-α-amino-n-valeric acid: N,O-dibenzoyl-δ-oxy-α-amino-n-valeric acid

Conditions

Conditions	Yield
in ganz schwach alkal.Loesung;

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 98-88-4
benzoyl chloride

N-monobenzoyl-δ-oxy-α-amino-n-valeric acid: N-monobenzoyl-δ-oxy-α-amino-n-valeric acid

Conditions

Conditions	Yield
in ausgepraegt alkal.Loesung;

: 533-88-0
2-amino-5-hydroxyvaleric acid

pyrrolidine-α-carboxylic acid: pyrrolidine-α-carboxylic acid

Conditions

Conditions	Yield
at 195 - 200℃;

: 7647-01-0
hydrogenchloride

: 533-88-0
2-amino-5-hydroxyvaleric acid

pyrrolidine-α-carboxylic acid: pyrrolidine-α-carboxylic acid

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 99864-61-6
2-(2,4-dinitro-phenylhydrazono)-5-hydroxy-valeric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: durch Einwirkung von Nieren-Praeparaten unter aeroben Bedingungen View Scheme

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 117342-48-0
5-chloro-2-(2,4-dinitro-anilino)-valeric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous ethanol; NaHCO3 2: acetyl chloride; PCl5 View Scheme

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 5-(3-hydroxy-propyl)-3-phenyl-imidazolidine-2,4-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NaOH solution / anschliessendes Behandeln mit Phenylisocyanat 2: aqueous HCl View Scheme

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 2221-09-2
Hexahydro-2-phenyl-1H-pyrrolo(1,2-c)imidazol-1,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. NaOH solution / anschliessendes Behandeln mit Phenylisocyanat 2: aqueous HCl 3: aqueous HBr<48percent > View Scheme

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 85535-47-3
2-tert-Butoxycarbonylamino-5-hydroxy-pentanoic acid

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 100-39-0
benzyl bromide

: O-benzyl-5-hydroxynorvaline

Conditions

Conditions	Yield
With hydrogenchloride In sodium hydroxide; water

: 533-88-0
2-amino-5-hydroxyvaleric acid

: 2-ethylamino-5-hydroxyvalerate methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid / 3 h / Reflux 2: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere View Scheme

: 533-88-0
2-amino-5-hydroxyvaleric acid

: methyl 5-bromo-2-ethylaminovalerate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sulfuric acid / 3 h / Reflux 2: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere 3: bromine / tetrachloromethane / 2 h / 60 °C View Scheme

Norvaline, 5-hydroxy- Specification

This chemical is called Norvaline, 5-hydroxy-, and its systematic name is Norvaline, 5-hydroxy-. With the molecular formula of C₅H₁₁NO₃, its molecular weight is 133.15. The CAS registry number of this chemical is 533-88-0. Additionally, it's specific marker of oxidized arginine and proline residues in proteins.

Other characteristics of the Norvaline, 5-hydroxy- can be summarised as followings: (1)ACD/LogP: -1.02; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.52; (4)ACD/LogD (pH 7.4): -3.52; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 38.77 Å²; (13)Index of Refraction: 1.504; (14)Molar Refractivity: 31.8 cm³; (15)Molar Volume: 107.2 cm³; (16)Polarizability: 12.6×10^-24cm³; (17)Surface Tension: 58 dyne/cm; (18)Density: 1.241 g/cm³; (19)Flash Point: 138.9 °C; (20)Enthalpy of Vaporization: 63.39 kJ/mol; (21)Boiling Point: 306.1 °C at 760 mmHg; (22)Vapour Pressure: 7.36E-05 mmHg at 25°C.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(O)C(N)CCCO
2.InChI: InChI=1/C5H11NO3/c6-4(5(8)9)2-1-3-7/h4,7H,1-3,6H2,(H,8,9)
3.InChIKey: CZWARROQQFCFJB-UHFFFAOYAE

Product Name

2-amino-5-hydroxyvaleric acid

Synthetic route

Norvaline, 5-hydroxy- Specification

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