IUPAC Name: 1,1,3,3,3-Pentafluoro-2-(trifluoromethyl)prop-1-ene
Synonyms of Octafluoro-sec-butene (CAS NO.382-21-8) : 1,1,3,3,3-Pentafluor-2-(trifluormethyl)-1-propen ; 1,1,3,3,3-Pentafluoro-2-(trifluoromethyl)prop-1-ene ; 1-Propene, 1,1,3,3,3-pentafluoro-2-(trifluoromethyl)- ; Perfluoroisobutene
InChI:InChI=1/C4F8/c5-2(6)1(3(7,8)9)4(10,11)12
CAS NO:382-21-8
Molecular Formula:C4F8
Molecular Weight :200.03
Molecular Structure :
Index of Refraction:1.26
Surface Tension: 10.5 dyne/cm
Density: 1.521 g/cm3
Enthalpy of Vaporization: 24.01 kJ/mol
Boiling Point: 1.2 °C at 760 mmHg
Vapour Pressure: 1740 mmHg at 25°C
Preparation Products: Hexafluoroacetone
Octafluoro-sec-butene (CAS NO.382-21-8) is a product of pyrolysis of polytetrafluoroethylene (PTFE), one of the substances causing polymer fume fever.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LCLo | inhalation | 25mg/m3/2H (25mg/m3) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA | Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 75, Pg. 221, 1963. |
guinea pig | LC50 | inhalation | 1050ppb/2H (1.05ppm) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Biologie Medicale Vol. 57, Pg. 247, 1968. |
mouse | LCLo | inhalation | 10mg/m3/2H (10mg/m3) | LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: HEMORRHAGE | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 5(3), Pg. 3, 1961. |
rabbit | LC50 | inhalation | 1200ppb/2H (1.2ppm) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Biologie Medicale Vol. 57, Pg. 247, 1968. |
rat | LC50 | inhalation | 500ppb/6H (0.5ppm) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 310, 1969. |
A deadly poison by inhalation. A skin, eye, and mucous membrane irritant. Human acute exposure causes marked irritation of conjunctivae, throat, and lungs. When heated to decomposition it emits toxic fumes of F−. See also FLUORIDES.
RIDADR 3162
HazardClass 2.3
ACGIH TLV: CL 0.01 ppm
Perfluoroisobutene (PFIB), also known as 1,1,3,3,3-pentafluoro-2-(trifluoromethyl)prop-1-ene, is a fluorocarbon olefine. It is a hydrophobic reactive gas with boiling point at 7 °C. It is a strong electrophile.
PFIB is about 10 times as toxic as phosgene. Its inhalation can lead to pulmonary edema, which may be fatal. Onset of symptoms can take 1-4 hours after inhalation. Treatment is based on management of the pulmonary edema (usually with high-dose corticoids and other medication/measures) and associated disorders (e.g. heart failure, hypocalcemia etc.). Many cases resolve within 72 hours without major long-term effects.
In contact with water PFIB undergoes rapid hydrolysis, producing various reactive compounds and fluorophosgene.
Octafluoro-sec-butene (CAS NO.382-21-8) is a Schedule 2 substance of the Chemical Weapons Convention.
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