IUPAC Name: [2-[2-[2-[[6-Amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[3-hydroxy-5-[[3-hydroxy-1-oxo-1-[2-[4-[4-[3-(1-phenylethylamino)propylcarbamoyl]-
1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]butan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-
imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate; sulfuric acid
Synonyms of Pepleomycin sulfate (CAS NO.70384-29-1) : N1-[3-[(1-Phenylethyl)amino]propyl]bleomycinamide Sulfate (1:1) (Salt) ; N1-[3-[[(S)-a-Methylbenzyl]amino]propyl]bleomycinamide Sulfate (1:1) (Salt) ; Pepleo ; Pepleomycin sulfate ; Peplomycin sulfate ; Peplomycin sulfate salt
Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
CAS NO:70384-29-1
Molecular Formula:C61H90N18O25S3
Molecular Weight :1571.6679
Molecular Structure :
EINECS: 274-588-4
Flash Point: 1064.4 °C
Enthalpy of Vaporization: 311.88 kJ/mol
Boiling Point: 1836.4 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Melting Point: 196-198°C
Appearance: Pepleomycin sulfate (CAS NO.70384-29-1) is pale yellow amorphous powder .
Pepleomycin sulfate (CAS NO.70384-29-1) is a derivative of Bleomycin with cytostatic activity and less pulmonary toxicity than the natural Bleomycin mixture.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD | intravenous | > 50mg/kg (50mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" GASTROINTESTINAL: OTHER CHANGES | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. |
mouse | LD50 | intraperitoneal | 77mg/kg (77mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. | |
mouse | LD50 | intravenous | 45mg/kg (45mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. | |
mouse | LD50 | oral | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. 6, Pg. 762, 1982. | |
mouse | LD50 | subcutaneous | 80mg/kg (80mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. | |
mouse | LDLo | intratracheal | 1572ng/kg (0.001572mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) | Toxicology and Applied Pharmacology. Vol. 56, Pg. 326, 1980. |
rat | LD50 | intraperitoneal | 155mg/kg (155mg/kg) | "Bleomycin: Current Status and New Development, Papers Presented in a Symposium, Oakland, CA, 1977," Carter, S.K., et al., eds., New York, Academic Press, Inc., 1978Vol. -, Pg. 311, 1978. | |
rat | LD50 | intravenous | 215mg/kg (215mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. | |
rat | LD50 | oral | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. 6, Pg. 762, 1982. | |
rat | LD50 | subcutaneous | 199mg/kg (199mg/kg) | Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978. |
Poison by intraperitoneal, subcutaneous, and intravenous routes. Questionable carcinogen with experimental carcinogenic data. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx.
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