Perindopril

The Perindopril is an organic compound with the formula C₁₉H₃₂N₂O₅. The IUPAC name of this chemical is (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid. With the CAS registry number 82834-16-0, it is also named as Perindopril Erbumine. The product's categories are Perindopril; Intermediates & Fine Chemicals; Pharmaceuticals. Besides, it is a long-acting ACE inhibitor, it can stable coronary artery disease and treat essential hypertension.

Physical properties about Perindopril are: (1)ACD/LogP: 3.36; (2)ACD/LogD (pH 5.5): 1.16; (3)ACD/LogD (pH 7.4): -0.15; (4)ACD/BCF (pH 5.5): 1.31; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 9.98; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 7; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 9; (11)Polar Surface Area: 76.15 Å²; (12)Index of Refraction: 1.512; (13)Molar Refractivity: 96.17 cm³; (14)Molar Volume: 320.3 cm³; (15)Polarizability: 38.12×10^-24cm³; (16)Surface Tension: 44.9 dyne/cm; (17)Density: 1.15 g/cm³; (18)Flash Point: 278.8 °C; (19)Enthalpy of Vaporization: 89.06 kJ/mol; (20)Boiling Point: 537.4 °C at 760 mmHg; (21)Vapour Pressure: 5.63E-13 mmHg at 25°C.

Preparation: this chemical can be prepared by Compound (I) and compounds (II).

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(OCC)[C@@H](N[C@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@H]12)C)CCC
(2)InChI: InChI=1/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
(3)InChIKey: IPVQLZZIHOAWMC-QXKUPLGCBD
(4)Std. InChI: InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
(5)Std. InChIKey: IPVQLZZIHOAWMC-QXKUPLGCSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 1600mg/kg (1600mg/kg)		Cardiovascular Drug Reviews. Vol. 10, Pg. 446, 1992.
monkey	LD50	oral	> 500mg/kg (500mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 1679, 1994.
mouse	LD50	intravenous	679mg/kg (679mg/kg)		Cardiovascular Drug Reviews. Vol. 10, Pg. 446, 1992.
mouse	LD50	oral	> 2500mg/kg (2500mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 1673, 1994.
rat	LD50	intravenous	323mg/kg (323mg/kg)		Cardiovascular Drug Reviews. Vol. 10, Pg. 446, 1992.
rat	LD50	oral	> 3gm/kg (3000mg/kg)		Cardiovascular Drug Reviews. Vol. 10, Pg. 446, 1992.
women	TDLo	oral	58mg/kg/2Y-I (58mg/kg)	BLOOD: AGRANULOCYTOSIS	Annales de Medecine Interne. Vol. 147, Pg. 523, 1996.