Product Name

  • Name

    Pindolol

  • EINECS 236-867-9
  • CAS No. 13523-86-9
  • Article Data18
  • CAS DataBase
  • Density 1.152 g/cm3
  • Solubility 0.1 M NaOH: 0.2 mg/mL
  • Melting Point 167-171 °C(lit.)
  • Formula C14H20N2O2
  • Boiling Point 457.132 °C at 760 mmHg
  • Molecular Weight 248.325
  • Flash Point 230.265 °C
  • Transport Information UN 3249
  • Appearance white to off-white crystalline powder
  • Safety 26-36
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 13523-86-9 (Pindolol)
  • Hazard Symbols HarmfulXn
  • Synonyms 2-Propanol,1-(indol-4-yloxy)-3-(isopropylamino)- (8CI);(RS)-Pindolol;(?à)-4-[2-Hydroxy-3-(isopropylamino)propoxy]indole;(?à)-LB 46;(?à)-Pindolol;1-[(1-Methylethyl)amino]-3-(4-indolyloxy)-2-propanol;4-(2-Hydroxy-3-isopropylaminopropoxy)indole;4-(3-Isopropylamino-2-hydroxypropoxy)indole;Apo-pindol;Betapindol;BlocklinL;Calvisken;Carvisken;DL-4-[2-Hydroxy-3-(isopropylamino)propoxy]indole;DL-LB 46;DL-Pindolol;Decreten;Durapindol;Glauco-Visken;LB 46;LB 46(pharmaceutical);N-[2-Hydroxy-3-(1H-indol-4-yloxy)propyl]-N-isopropylamine;Pectobloc;Pinbetol;Pindolol;Prinodolol;Pynastin;Visken;
  • PSA 57.28000
  • LogP 2.29650

Pindolol Specification

The IUPAC name of Visken is 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol. With the CAS registry number 13523-86-9 and EINECS 236-867-9, it is also named as Pindolol. The product's categories are Heterocyclic Compounds; Pindolol; Serotonin Receptor. It is white to off-white crystalline powder which is easily soluble in acetic acid, slightly soluble in methanol, insoluble in water or benzene. When heated to decomposition it emits toxic fumes of NOx.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.97; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.06; (4)ACD/LogD (pH 7.4): 0.07; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 3.5; (9)#H bond acceptors: 4; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 26.63 Å2; (13)Index of Refraction: 1.596; (14)Molar Refractivity: 73.41 cm3; (15)Molar Volume: 215.4 cm3; (16)Surface Tension: 47.5 dyne/cm; (17)Enthalpy of Vaporization: 75.57 kJ/mol; (18)Vapour Pressure: 3.77E-09 mmHg at 25°C; (19)Rotatable Bond Count: 6; (20)Exact Mass: 248.152478; (21)MonoIsotopic Mass: 248.152478; (22)Topological Polar Surface Area: 57.3; (23)Heavy Atom Count: 18; (24)Complexity: 248.

Preparation and Uses of Visken: It can be obtained by the amination of 4-(1,2-epoxypropoxy) indole and isopropylamine. Visken is a nonselective beta blocker with partial beta-adrenergic receptor agonist activity. What's more, it is sometimes added to a standard antidepressant therapy, if the patient fails to respond to the standard therapy alone.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful if swallowed, but also irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:OC(CNC(C)C)COc1cccc2c1ccn2
2. InChI:InChI=1/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3 
3. InChIKey:JZQKKSLKJUAGIC-UHFFFAOYAP

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 71ug/kg/1D-I (0.071mg/kg) BEHAVIORAL: TREMOR Postgraduate Medical Journal. Vol. 56, Pg. 346, 1980.
mouse LD50 intraperitoneal 80mg/kg (80mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 3573, 1981.
mouse LD50 intravenous 22600ug/kg (22.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 794, 1978.
mouse LD50 oral 235mg/kg (235mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Journal of Toxicological Sciences. Vol. 6, Pg. 301, 1981.
mouse LD50 subcutaneous 336mg/kg (336mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rabbit LD50 intravenous 10mg/kg (10mg/kg)   Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rabbit LD50 oral 650mg/kg (650mg/kg)   Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rat LD50 intraperitoneal 110mg/kg (110mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
rat LD50 intravenous 51mg/kg (51mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA		 Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rat LD50 oral 263mg/kg (263mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rat LD50 subcutaneous 251mg/kg (251mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR		 Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
women TDLo oral 300ug/kg/3D-I (0.3mg/kg) BEHAVIORAL: TREMOR Postgraduate Medical Journal. Vol. 56, Pg. 346, 1980.

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