Product Name

  • Name

    Pizotifen Malate

  • EINECS 225-970-4
  • CAS No. 5189-11-7
  • Density 1.164 g/cm3
  • Solubility
  • Melting Point 185-186° (dec)
  • Formula C19H21NS
  • Boiling Point 436.7 °C at 760 mmHg
  • Molecular Weight 429.53
  • Flash Point 217.9 °C
  • Transport Information
  • Appearance
  • Safety 26-37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 5189-11-7 (Pizotifen Malate)
  • Hazard Symbols Xi
  • Synonyms Butanedioicacid, hydroxy-, compd. with4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine(1:1) (9CI);Malic acid, compd. with 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine(1:1) (8CI);Malic acid, compd. with4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine(7CI);4H-Benzo[4,5]cyclohepta[1,2-b]thiophene, 9,10-dihydro-4-(1-methyl-4-piperidylidene)-,malate (1:1) (8CI);4H-Benzo[4,5]cyclohepta[1,2-b]thiophene, piperidine deriv.;Piperidine,4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-,hydroxybutanedioate (1:1) (9CI);Piperidine, 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-,malate (1:1) (8CI);4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidiniumhydrogen malate;Mosegor;Pizotifen hydrogen malate;Pizotifen malate;Pizotyline malate;Sanmigran;Sanomigran;
  • PSA 106.08000
  • LogP 4.02390

Pizotifen malate Chemical Properties

Product Name: Pizotyline malate (CAS NO.5189-11-7)


Molecular Formula: C23H27NO5S
Molecular Weight: 429.53g/mol
Mol File: 5189-11-7.mol
Einecs: 225-970-4
Boiling point: 436.7 °C at 760 mmHg
Flash Point: 217.9 °C
Enthalpy of Vaporization: 69.32 kJ/mol
Vapour Pressure: 7.92E-08 mmHg at 25
H-Bond Donor: 3
H-Bond Acceptor: 6
InChI: InChI=1S/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-
18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,
1H2,(H,6,7)(H,8,9) 
InChIKey: IWAWCPZVTXCFKD-UHFFFAOYSA-N
Product Categories: Active Pharmaceutical Ingredients

Pizotifen malate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 43mg/kg (43mg/kg)   Japanese Journal of Pharmacology. Vol. 19, Pg. 19, 1969.
rabbit LD50 intravenous 19mg/kg (19mg/kg)   Japanese Journal of Pharmacology. Vol. 19, Pg. 19, 1969.
rat LD50 intravenous 17mg/kg (17mg/kg)   Japanese Journal of Pharmacology. Vol. 19, Pg. 19, 1969.
women TDLo oral 600ug/kg (0.6mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Postgraduate Medical Journal. Vol. 63, Pg. 59, 1987.

Pizotifen malate Safety Profile

Safety Information of Pizotyline malate (CAS NO.5189-11-7):
Hazard Codes: Xi
Risk Statements: 36/37/38
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
Safety Statements: 26-37/39
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
37:  Wear suitable gloves  
39:  Wear eye/face protection 

Pizotifen malate Specification

 Pizotyline malate ,its CAS NO. is 5189-11-7,the synonyms is Litec malate ; Mosegor ; Pizotifen hydrogen malate ; Pizotifen malate ; Sandomigran malate ; Sandomygran malate ; Sanomtgran ; Malic acid, compound with 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-methylpiperidine (1:1) ; Piperidine, 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-methyl-, malate (1:1) .

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