Product Name

  • Name

    Procaine hydrochloride

  • EINECS 200-077-2
  • CAS No. 1951-5-8
  • Density
  • Solubility
  • Melting Point 155-156 °C(lit.)
  • Formula
  • Boiling Point 195-196°C 17mm
  • Molecular Weight 272.77
  • Flash Point 195-196°C/17mm
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 1951-5-8 (Procaine hydrochloride)
  • Hazard Symbols
  • Synonyms aminocaine;anadolor;anesthesol;anestil;atoxicocaine;Benzoicacid,4-amino-,2-(diethylamino)ethylester,monohydrochloride;benzoicacid,p-amino-,2-(diethylamino)ethylester,monohydrochloride;bernocaine
  • PSA
  • LogP

Procaine HCL Chemical Properties

Molecular Formula: C13H20N2O2.HCl
Molecular Weight: 272.77
EINECS: 200-077-2
Melting point: 154-158 ºC
Water solubility: soluble
Sensitive: Air Sensitive
Flash Point: 179.8 °C 
Enthalpy of Vaporization: 62.09 kJ/mol 
Boiling Point: 373.6 °C at 760 mmHg 
Vapour Pressure: 8.84E-06 mmHg at 25°C 
Appearance of Procaine HCL (1951-5-8): white crystalline powder
Product Categories: Pharmaceutical;Sodium channel
Stability: Stable. Incompatible with strong oxidizing agents.
Synonyms: Aminocaine ; Anadolor ; Anesthesol ; Anestil ; Atoxicocaine ; Benzoicacid,4-amino-,2-(diethylamino)ethylester,monohydrochloride ; Benzoicacid,p-amino-,2-(diethylamino)ethylester,monohydrochloride ; Bernocaine
Following is the molecular structure of Procaine HCL (1951-5-8):

 

Procaine HCL Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 10mg/kg (10mg/kg)
Behavioral: convulsions or effect
on seizure threshold
Cardiac: change in rate
 Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 385, 1916.
dog LD50 intravenous 63mg/kg (63mg/kg)
Cardiac: other changes
Vascular: bp lowering not characterized in autonomic section lungs, thorax, or
Respiration: respiratory depression
 Journal of Dental Research. Vol. 20, Pg. 425, 1941.
dog LDLo intracrebral 11mg/kg (11mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 137, 1959.
guinea pig LD50 intravenous 51mg/kg (51mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.
guinea pig LD50 subcutaneous 407mg/kg (407mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948.
mammal (species unspecified) LD50 subcutaneous 630mg/kg (630mg/kg)   Ceska a Slovenska Farmacie. Vol. 44, Pg. 210, 1995.
man TDLo multiple routes 2286mg/kg/8D- (2286mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" American Journal of Kidney Diseases. Vol. 7, Pg. 502, 1986.
mouse LD50 intracrebral 33mg/kg (33mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63(3), Pg. 93S, 1967.
mouse LD50 intramuscular 500mg/kg (500mg/kg)   Therapie. Vol. 9, Pg. 332, 1954.
mouse LD50 intraperitoneal 165mg/kg (165mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 793, 1976.
mouse LD50 intravenous 33mg/kg (33mg/kg)   Anesthesia Progress. Vol. 36, Pg. 79, 1989.
mouse LD50 oral 175mg/kg (175mg/kg)   Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.
mouse LD50 parenteral 192mg/kg (192mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: EXCITEMENT		 Antibiotics and Chemotherapy Vol. 4, Pg. 633, 1954.
mouse LD50 subcutaneous 339mg/kg (339mg/kg)   Bollettino Chimico Farmaceutico. Vol. 107, Pg. 310, 1968.
rabbit LD50 intracrebral 4800ug/kg (4.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: ATAXIA		 Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 137, 1959.
 
rabbit LD50 intravenous 43mg/kg (43mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rabbit LD50 subcutaneous 687mg/kg (687mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948.
rabbit LD50 unreported 41mg/kg (41mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1957, 1974.
 
rabbit LDLo intraspinal 15504ug/kg (15.504mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC Anesthesiology. Vol. 1, Pg. 305, 1940.
rat LD50 intraperitoneal 160mg/kg (160mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.
rat LD50 intravenous 38mg/kg (38mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Anesthesiology. Vol. 3, Pg. 398, 1942.
rat LD50 oral 200mg/kg (200mg/kg)   Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. Vol. 6B, Pg. 183, 1951.
rat LD50 subcutaneous 597mg/kg (597mg/kg)   Pharmaceutical Archives. Vol. 11, Pg. 81, 1940.
rat LD50 unreported 150mg/kg (150mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1012, 1967.

Procaine HCL Safety Profile

Safety Information of Procaine HCL (1951-5-8):
Hazard Codes: T 
T: Toxic 
Risk Statements: 25-43-36/37/38-23/24/25
25:  Toxic if swallowed 
43:  May cause sensitization by skin contact 
36/37/38: Irritating to eyes, respiratory system and skin 
23/24/25: Toxic by inhalation, in contact with skin and if swallowed 
Safety Statements: 36/37/39-45-37/39-26
36/37/39: Wear suitable protective clothing, gloves and eye/face protection 
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
37/39: Wear suitable gloves and eye/face protection 
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: DG2275000
HazardClass: 6.1
PackingGroup: III

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